Spatial and temporal clustering of anti-SARS-CoV-2 antibodies in Illinois household cats, 2021-2023

Chen, Chi; Martins, Mathias; Nooruzzaman, Mohammed; Yettapu, Dipankar; Diel, Diego G.; Reinhart, Jennifer M.; Urbasic, Ashlee; Robinson, Hannah; Varga, Csaba; Fang, Ying

doi:10.1101/2023.06.21.23291564

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…Experimental studies have, however, demonstrated cats' high susceptibility to SARS-CoV-2 infections and their potential to transmit the virus through close contact (11). Numerous studies have now reported seroprevalence of SARS-CoV-2 in domestic, shelter, and stray cats, yielding variable prevalence (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Despite now extensive global documentation, data on the seroprevalence of SARS-CoV-2 in U.S. domestic cats remains relatively scarce (23)(24)(25)(26)(27), especially during the early stages of the pandemic.…”

Section: Introductionmentioning

confidence: 99%

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SARS-CoV-2 serosurvey of healthy, privately owned cats presenting to a New York City animal hospital in the early phase of the COVID-19 pandemic (2020-2021)

Choi,

Stout,

Rollins

et al. 2024

Preprint

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Both domestic and non-domestic cats are now established to be susceptible to infection by SARS-CoV-2, the cause of the ongoing COVID-19 pandemic. While serious disease in cats may occur in some instances, the majority of infections appear to be subclinical. Differing prevalence data for SARS-CoV-2 infection of cats have been reported, and are highly context-dependent. Here, we report a retrospective serological survey of cats presented to an animal practice in New York City, located in close proximity to a large medical center that treated the first wave of COVID-19 patients in the US in the Spring of 2020. We sampled 79, mostly indoor, cats between June 2020 to May 2021, the early part of which time the community was under a strict public health lock-down. Using a highly sensitive and specific fluorescent bead-based multiplex assay, we found an overall prevalence of 13/79 (16%) serologically-positive animals for the study period; however, cats sampled in the Fall of 2020 had a confirmed positive prevalence of 44%. For SARS-CoV-2 seropositive cats, we performed viral neutralization test with live SARS-CoV-2 to additionally confirm presence of SARS-CoV-2 specific antibodies. Of the thirteen seropositive cats, 7/13 (54%) were also positive by virus neutralization, and 2 of seropositive cats had previously documented respiratory signs, with high neutralization titers of 1:1024 and 1:4096; overall however, there was no statistically significant association of SARS-CoV-2 seropositivity with respiratory signs, or with breed, sex or age of the animals. Follow up sampling of cats, while limited in scope, showed that positive serological titers were maintained over time. In comparison, we found an overall confirmed positive prevalence of 51% for feline coronavirus (FCoV), an endemic virus of cats, with 30% confirmed negative for FCoV. We demonstrate the impact of SARS-CoV in a defined feline population during the first wave of SARS-CoV-2 infection of humans, and suggest that human-cat transmission was substantial in our study group. Our data provide a new context for SARS-CoV-2 transmission events across species.

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Section: Introductionmentioning

confidence: 99%

“…Numerous studies have now reported seroprevalence of SARS-CoV-2 in domestic, shelter, and stray cats, yielding variable prevalence (12–27). Despite now extensive global documentation, data on the seroprevalence of SARS-CoV-2 in U.S. domestic cats remains relatively scarce (23–27), especially during the early stages of the pandemic.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 serosurvey of healthy, privately owned cats presenting to a New York City animal hospital in the early phase of the COVID-19 pandemic (2020-2021)

Choi,

Stout,

Rollins

et al. 2024

Preprint

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Backyard zoonoses: The roles of companion animals and peri-domestic wildlife

Gamble,

Olarte-Castillo,

Whittaker

2023

Sci. Transl. Med.

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The spillover of human infectious diseases from animal reservoirs is now well appreciated. However, societal and climate-related changes are affecting the dynamics of such interfaces. In addition to the disruption of traditional wildlife habitats, in part because of climate change and human demographics and behavior, there is an increasing zoonotic disease risk from companion animals. This includes such factors as the awareness of animals kept as domestic pets and increasing populations of free-ranging animals in peri-domestic environments. This review presents background and commentary focusing on companion and peri-domestic animals as disease risk for humans, taking into account the human-animal interface and population dynamics between the animals themselves.

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Spatial and temporal clustering of anti-SARS-CoV-2 antibodies in Illinois household cats, 2021-2023

Cited by 2 publications

References 40 publications

SARS-CoV-2 serosurvey of healthy, privately owned cats presenting to a New York City animal hospital in the early phase of the COVID-19 pandemic (2020-2021)

SARS-CoV-2 serosurvey of healthy, privately owned cats presenting to a New York City animal hospital in the early phase of the COVID-19 pandemic (2020-2021)

Backyard zoonoses: The roles of companion animals and peri-domestic wildlife

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