“…For example, multiple studies used large-sample datasets to investigate the drivers of hydrological change (e.g., Slater et al, 2015;Blöschl et al, 2019a;Gudmundsson et al, 2019), the impacts of anthropic activities on the water cycle (e.g., Milliman et al, 2008;Hoekstra and Mekonnen, 2012;Montanari et al, 2013), hydrological similarity and classification (e.g., Berghuijs et al, 2014;Sawicz et al, 2014;Knoben et al, 2018), predictions in ungauged basins (e.g., Yadav et al, 2007;Ehret et al, 2014;Singh et al, 2014), areas where ex-V. B. P. Chagas et al: CAMELS-BR treme events are a concern (e.g., Van Lanen et al, 2013;Villarini, 2016;Woldemeskel and Sharma, 2016), and the prediction of future hydrological change (e.g., Luke et al, 2017;Zscheischler et al, 2018). Moreover, large-sample hydrology is needed for evaluation of continental to global hydrological models; to identify limitations in model structure, parameterization, and forcing according to geographic and climatic regions (Haddeland et al, 2011;Gudmundsson et al, 2012;Beck et al, 2017a;Zhao et al, 2017;Siqueira et al, 2018;Veldkamp et al, 2018); to estimate uncertainty in model estimates (e.g., Müller Schmied et al, 2014;Beck et al, 2016;Hirpa et al, 2018); and to make use of data assimilation techniques (e.g., Wongchuig et al, 2019). Better predictions in such models allow for the quantification of water resources availability over large scales and are fundamental for nationwide water resources planning and management (Schewe et al, 2014;Döll et al, 2016;Alfieri et al, 2020).…”