Spatial and non-spatial working memory at different stages of Parkinson's disease

Owen, Adrian M.; Iddon, Joanna L.; Hodges, John R.; Summers, Beatrice A.; Robbins, Trevor W.

doi:10.1016/s0028-3932(96)00101-7

Cited by 319 publications

(183 citation statements)

References 48 publications

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“…Additional evidence that frontostriatal neural circuitry participates in WM is provided by single unit recordings and lesion studies in animals (Apicella et al, 1992;Battig et al, 1960) and lesion and dysfunction studies in humans (Owen et al, 1997;Partiot et al, 1996). However, the role of this circuitry in WM is not understood.…”

Section: Discussionmentioning

confidence: 99%

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

et al. 2003

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This study describes the neural circuitry underlying temporally separated components of working memory (WM) performance-stimulus encoding, maintenance of information during a delay, and the response to a probe. While other studies have applied event-related fMRI to separate epochs of WM tasks, this study differs in that it employs a methodology that does not make any a priori assumptions about the shape of the hemodynamic response (HDR). This is important because no one model of the HDR is valid across the range of activated brain regions and stimulus types. Systematic modeling inaccuracies may lead to the misattribution of activity to adjacent events. Twelve healthy subjects performed a numerical version of the Sternberg Item Recognition Paradigm adapted for rapid presentation event-related fMRI. This paradigm emphasized maintenance rather than manipulative WM processes and used a subcapacity WM load. WM trials with different delay lengths were compared to fixation. The HDR of the entire WM trial for each trial type was estimated using a finite impulse response (FIR). Regional activity associated with the Encode, Delay, and Probe epochs was identified using contrasts that were based on the FIR estimates and by examining the HDRs. Each epoch was associated with a distinct but overlapping pattern of regional activity. Activation of the dorsolateral prefrontal cortex, thalamus, and basal ganglia was exclusively associated with the probe. This suggests that frontostriatal neural circuitry participates in selecting an appropriate response based on the contents of WM.

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Section: Discussionmentioning

confidence: 99%

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

et al. 2003

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“…Tests of visual memory, such as pattern recognition memory (PRM), activate the temporal lobes (Kimura, 1963;Piggott & Milner, 1993), the hippocampus (Mishkin, 1982) and amygdala (Owen et al, 1995). Working memory tests activate the frontal cortex (Petrides & Milner, 1982;Goldman-Rakic, 1987;Owen et al, 1997). Tests of attention such as simple or 5-choice reaction time (RT) and match to sample visual search (MTS) activate the frontostriatal circuitry (Sahakian et al, 1990;Chari et al, 1996).…”

Section: Methodsmentioning

confidence: 99%

Cognitive function in healthy older European adults: the ZENITH study

et al. 2005

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Objective: Baseline data are reported from a study of the effects of zinc supplementation on cognitive function in older adults as assessed by the CANTAB computerised test battery. Design: This is a multicentre prospective intervention study employing a randomised double-blind design. Setting: European community-based study. Participants: There are 387 healthy adults aged 55-87 y from centres in France, Italy and Northern Ireland. Interventions: Measures of visual memory, working memory and attention were obtained at baseline (prior to supplementation). Results: Younger adults (o70 y) performed significantly better than older adults (470 y) on all tests, with minimal differences between centres. In addition, men outperformed women on tests of spatial span, pattern recognition memory and reaction times, although these gender differences varied somewhat between centres. Conclusions: The results are generally consistent with previous age-and gender-related effects on cognitive functioning.

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“…In addition to these, PD has been associated with a number of cognitive deficits. Dementia is prevalent in PD patients (Aarsland et al, 2005), but there is a range of less severe cognitive symptoms of PD, related to working memory (Owen et al, 1997), attention (Filoteo and Maddox, 1999), set-shifting (Cools et al, 2001b), and procedural learning (Saint-Cyr et al, 1988). PD patients have also been shown to be impaired in category learning (Ashby et al, 2003;Filoteo et al, 2005Filoteo et al, , 2007Knowlton et al, 1996;Maddox et al, 2005;Shohamy et al, 2004b).…”

Section: Introductionmentioning

confidence: 99%

Models of probabilistic category learning in Parkinson’s disease: Strategy use and the effects of L-dopa

Speekenbrink

Lagnado

Wilkinson

et al. 2010

Journal of Mathematical Psychology

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Spatial and non-spatial working memory at different stages of Parkinson's disease

Cited by 319 publications

References 48 publications

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI

Cognitive function in healthy older European adults: the ZENITH study

Models of probabilistic category learning in Parkinson’s disease: Strategy use and the effects of L-dopa

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