Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan

Sugauchi, Fuminaka; Orito, Etsuro; Ohno, Tomoyoshi; Tanaka, Yasuhito; Ozasa, Atsushi; Kang, Jong-Hon; Toyoda, Joji; Kuramitsu, Tomoyuki; Suzuki, Kazuyuki; Tanaka, Eiji; Akahane, Yoshihiro; Ichida, Takafumi; Izumi, Namiki; Inoue, Kazuaki; Hoshino, Hiromi; Iino, Shiro; Yotsuyanagi, Hiroshi; Kakumu, Shinichi; Tomita, Eiichi; Okanoue, Takeshi; Nishiguchi, Shuhei; Murawaki, Yoshikazu; Hino, Keisuke; Onji, Morikazu; Yatsuhashi, Hiroshi; Sata, Michio; Miyakawa, Yuzo; Ueda, Ryuzo; Mizokami, Masashi

doi:10.1016/j.hepres.2006.06.001

Cited by 60 publications

(61 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Japan, HBV/A is detected rarely among patients with CHB but is frequent in those with acute hepatitis (14,25,29,41,43). Yotsuyanagi et al reported the distribution of genotypes in 145 Japanese patients with AHB and found HBV/A in 27 (19%), HBV/B in 8 (5%), and HBV/C in 109 (75%) (49).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it was reported that HBV/A was more frequent in patients with acute hepatitis than in those with chronic hepatitis (29,41,49). Recent studies suggest that the chances for progression to chronic disease may differ among patients acutely infected with HBV of distinct genotypes (21,25); patients infected with HBV/A run an increased risk of becoming HBV carriers.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Distribution of Hepatitis B Virus Genotypes among Patients with Chronic Infection in Japan Shifting toward an Increase of Genotype A

et al. 2009

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Distribution of Hepatitis B Virus Genotypes among Patients with Chronic Infection in Japan Shifting toward an Increase of Genotype A

et al. 2009

View full text Add to dashboard Cite

show abstract

“…In Japan, genotypes B and C are the predominant genotypes; however, the distribution of genotypes is changing (6)(7)(8). It has been reported that the main transmission route is vertical in genotypes B and C and horizontal in genotypes A and D (4,9).…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Hepatitis B Virus (HBV) Genotypes in Pregnant Women Chronically Infected with HBV

et al. 2012

View full text Add to dashboard Cite

Objective The purpose of this study was to clarify the clinical features and hepatitis B virus (HBV) genotypes in pregnant women chronically infected with HBV. Methods Among 1,489 pregnant women who visited our hospital in 2010, 26 were positive for hepatitis B surface antigens (HBsAg). Of these subjects, 21 from whom informed consent was obtained were included in this study. The clinical features and HBV markers, including genotypes, were investigated. Results No adverse events were observed in the subjects or the neonates during pregnancy or the perinatal period. The HBV genotypes were C in 14 cases, D in six cases, and undetermined in one case. Hepatitis B e antigens and a high viral load (>7.0 log copies/mL) were found in four and six subjects with genotype C, respectively, and in none of subjects with genotype D. The alanine aminotransferase (ALT) levels and platelet counts were within the normal ranges during pregnancy in all subjects except two and three subjects with genotype C, respectively. Three subjects with genotype C showed transient elevations of ALT after delivery. Conclusion The majority of subjects were anti-HBe-positive with normal ALT levels; however, some subjects with genotype C showed a high viral load, elevated ALT levels and/or low platelet counts. The pregnancies and deliveries were safe; however, transient elevations of ALT after delivery were observed in some subjects with genotype C.

show abstract

“…HBV genotype A is more frequently associated with chronic infection (occurring in 10-15% of those with acute infection) when compared with other genotypes (23). More than half of patients with acute hepatitis B due to horizontal infection are HBV genotype A (24), suggesting that it is important to avoid HBV genotype A infection as a sexually transmitted disease.…”

Section: Discussionmentioning

confidence: 99%

An HBV-HIV Co-infected Patient Treated with Tenofovir-based Therapy who Achieved HBs Antigen/Antibody Seroconversion

et al. 2014

View full text Add to dashboard Cite

The present report describes a case of a patient with hepatitis B virus (HBV)-human immunodeficiency virus (HIV) co-infection who was treated with tenofovir disoproxil (TDF)-based highly active antiretroviral therapy (HAART) and who achieved HBs antigen (Ag)/antibody (Ab) seroconversion. An 18-year-old Japanese man with HIV and HBV co-infection presented to our hospital. His CD4 count was decreased, and TDF-based HARRT was started. At 30 months after initiation of therapy, HBsAg was not detected. At 36 months after initiation of therapy, HBsAb was detected. We conclude that TDF-based therapy is useful for the management of patients with HBV and HIV co-infection.

show abstract

Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan

Cited by 60 publications

References 54 publications

Distribution of Hepatitis B Virus Genotypes among Patients with Chronic Infection in Japan Shifting toward an Increase of Genotype A

Distribution of Hepatitis B Virus Genotypes among Patients with Chronic Infection in Japan Shifting toward an Increase of Genotype A

Clinical Features and Hepatitis B Virus (HBV) Genotypes in Pregnant Women Chronically Infected with HBV

An HBV-HIV Co-infected Patient Treated with Tenofovir-based Therapy who Achieved HBs Antigen/Antibody Seroconversion

Contact Info

Product

Resources

About