Spatial analyzes of triatomine infestation indices and their association to the actions of a Chagas disease program and environmental variables during a 5-year intervention period

Weinberg, Diego; Porcasi, Ximena; Lanfri, Sofía; Abril, Marcelo; Scavuzzo, Carlos Marcelo

doi:10.1016/j.actatropica.2018.08.025

Cited by 11 publications

(18 citation statements)

References 41 publications

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“…Several studies have investigated species behaviours that influence short distance travel in and around homes, such as host-seeking, aggregation and dispersal [9][10][11][12][13][14][15][16][17][18][19], but fewer studies have considered the larger-scale geographical distributions of these species. The studies of geographical species distributions that have been conducted typically focus on a single country or a region within a country [19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Modelling geospatial distributions of the triatomine vectors of Trypanosoma cruzi in Latin America

et al. 2020

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Approximately 150 triatomine species are suspected to be infected with the Chagas parasite, Trypanosoma cruzi, but they differ in the risk they pose to human populations. The largest risk comes from species that have a domestic life cycle and these species have been targeted by indoor residual spraying campaigns, which have been successful in many locations. It is now important to consider residual transmission that may be linked to persistent populations of dominant vectors, or to secondary or minor vectors. The aim of this project was to define the geographical distributions of the community of triatomine species across the Chagas endemic region. Presence-only data with over 12, 000 observations of triatomine vectors were extracted from a public database and target-group background data were generated to account for sampling bias in the presence data. Geostatistical regression was then applied to estimate species distributions and fine-scale distribution maps were generated for thirty triatomine vector species including those found within one or two countries and species that are more widely distributed from northern Argentina to Guatemala, Bolivia to southern Mexico, and Mexico to the southern United States of America. The results for Rhodnius pictipes, Panstrongylus geniculatus, Triatoma dimidiata, Triatoma gerstaeckeri, and Triatoma infestans are presented in detail, including model predictions and uncertainty in these predictions, and the model validation results for each of the 30 species are presented in full. The predictive maps for all species are made publicly available so that they can be used to assess the communities of vectors present within different regions of the endemic zone. The maps are presented alongside key indicators for the capacity of each species to transmit T. cruzi to humans. These indicators include infection prevalence, evidence for human blood meals, and colonisation or invasion of homes. A summary of the published evidence for these indicators shows that the majority of the 30 species mapped by this study have the potential to transmit T. cruzi to humans.

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Section: Introductionmentioning

confidence: 99%

Modelling geospatial distributions of the triatomine vectors of Trypanosoma cruzi in Latin America

et al. 2020

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“…In February 2005, Mundo Sano Foundation (Fundacion Mundo Sano, FMS), a nongovernmental foundation in Argentina working for the prevention and control of communicable diseases, introduced the Integral Chagas Program (IChP), which consists of complementary approaches supporting the ongoing traditional practices of vector control in Añatuya, Santiago del Estero. IChP encourages community participation in activities aimed at interrupting vector domicile transmission by i) surveillance and control (S&C) of T. infestans based on spraying with pyrethroid insecticides; and ii) improving the quality of dwellings and the peridomestic situation (Abril et al, 2009;Weinberg et al, 2018). Verbal consent is obtained from the responsible adult dwellers in order to join the programme.…”

Section: Introductionmentioning

confidence: 99%

“…The house improvement subprogramme, described by Weinberg et al (2018), includes actions meant to reduce triatomine infestation by: i) waterproofing of roofs, walls and ceilings includ-ing washing of walls externally and internally; and ii) peri-domestic organization including enhancing structures, such as goat pens and chicken coops. Improvements in each household were always carried out by the community in a solidarity manner, where, those unable to improve their own house were helped by other community members (Abril et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Evaluation and planning of Chagas control activities using geospatial tools

Weinberg

Lanfri²,

Scavuzzo³

et al. 2019

Geospat Health

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Chagas continues to be a relevant public health problem in Latin America. In this work, we present a spatiotemporal analysis applied for the evaluation and planning of Chagas vector control strategies. We analysed the spatial distribution of the vector Triatoma infestans infestation related to ongoing control interventions cycles in rural communities near Añatuya, Santiago del Estero, Argentina. A geographical information system was developed for the spatial analysis obtaining, for each house, variables that describe the history of spraying and infestation at each time of interventions. Bi-dimensional histograms were used to describe the spatiotemporal pattern of these activities and peri-domestic infestation at the last intervention was modelled by a neural network model. We qualitatively evaluate control programmes considering the history of infestation and spraying from a spatiotemporal point of view, incorporating new ways of visualising this information. Predictions are based on novel, non-linear models and spatiotemporal indices, which should be useful for strategically allocating Chagas control resources in the future and thus help to better plan spraying strategies.

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“…While the MoH personnel searched for bugs, a collaborator of the Laboratory of Applied Entomology and Parasitology (LENAP) surveyed a member of the household regarding Capacities, Aptitudes, and Practices (CAP) as previously described [ 7 , 11 , 17 ]. 2) Flush-out: After searching each house, the walls and roof were systematically sprayed with cypermethrin, an irritating insecticide, causing the bugs to emerge from their hiding places for capture [ 19 , 20 ], in November 2018. 3) Community participation: While doing the entomological surveys, personnel from MoH and LENAP provided collecting supplies and explained to residents how to collect and record relevant information for any bug found later in the house.…”

Section: Methodsmentioning

confidence: 99%

Assessing risk of vector transmission of Chagas disease through blood source analysis using LC-MS/MS for hemoglobin sequence identification

et al. 2022

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Chagas disease is mainly transmitted by triatomine insect vectors that feed on vertebrate blood. The disease has complex domiciliary infestation patterns and parasite transmission dynamics, influenced by biological, ecological, and socioeconomic factors. In this context, feeding patterns have been used to understand vector movement and transmission risk. Recently, a new technique using Liquid chromatography tandem mass spectrometry (LC-MS/MS) targeting hemoglobin peptides has showed excellent results for understanding triatomines’ feeding patterns. The aim of this study was to further develop the automated computational analysis pipeline for peptide sequence taxonomic identification, enhancing the ability to analyze large datasets data. We then used the enhanced pipeline to evaluate the feeding patterns of Triatoma dimidiata, along with domiciliary infestation risk variables, such as unkempt piles of firewood or construction material, cracks in bajareque and adobe walls and intradomiciliary animals. Our new python scripts were able to detect blood meal sources in 100% of the bugs analyzed and identified nine different species of blood meal sources. Human, chicken, and dog were the main blood sources found in 78.7%, 50.4% and 44.8% of the bugs, respectively. In addition, 14% of the bugs feeding on chicken and 15% of those feeding on dogs were captured in houses with no evidence of those animals being present. This suggests a high mobility among ecotopes and houses. Two of the three main blood sources, dog and chicken, were significantly (p < 0.05) affected by domiciliary infestation risk variables, including cracks in walls, construction material and birds sleeping in the intradomicile. This suggests that these variables are important for maintaining reproducing Triatoma dimidiata populations and that it is critical to mitigate these variables in all the houses of a village for effective control of these mobile vectors.

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Spatial analyzes of triatomine infestation indices and their association to the actions of a Chagas disease program and environmental variables during a 5-year intervention period

Cited by 11 publications

References 41 publications

Modelling geospatial distributions of the triatomine vectors of Trypanosoma cruzi in Latin America

Modelling geospatial distributions of the triatomine vectors of Trypanosoma cruzi in Latin America

Evaluation and planning of Chagas control activities using geospatial tools

Assessing risk of vector transmission of Chagas disease through blood source analysis using LC-MS/MS for hemoglobin sequence identification

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