Spatholobus suberectus Ameliorates Diabetes-Induced Renal Damage by Suppressing Advanced Glycation End Products in db/db Mice

Ho, Moon; Hur, Jinyoung; Choi, Ji‐Won; Kim, Yoon‐Sook; Ha, Sang Keun

doi:10.3390/ijms19092774

Cited by 23 publications

(20 citation statements)

References 38 publications

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“…These natural compounds showed antioxidant effects and exerted anti-diabetic and anti-lipogenic potentials in in vitro studies [21][22][23][24][25]. In the current study, a high dose of LBE supplementation reduced the levels of HbA1c along with RAGE, which was considered as an index of chronic hyperglycemic states [26], although a low dose of LBE treatment decreased only HbA1c, which is a more useful clinical biomarker of diabetes. Therefore, one can conclude that LBE is beneficial for attenuating the hyperglycemic condition in T2DM.…”

Section: Discussionmentioning

confidence: 53%

Effects of Lespedeza Bicolor Extract on Regulation of AMPK Associated Hepatic Lipid Metabolism in Type 2 Diabetic Mice

et al. 2019

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Lespedeza bicolor (LB) is one of the ornamental plants used for the treatment of inflammation caused by oxidative damage. However, its beneficial effects on hyperglycemia-induced hepatic damage and the related molecular mechanisms remain unclear. We hypothesized that Lespedeza bicolor extract (LBE) would attenuate hyperglycemia-induced liver injury in type 2 diabetes mellitus (T2DM). Diabetes was induced by a low dosage of streptozotocin (STZ) injection (30 mg/kg) with a high fat diet in male C57BL/6J mice. LBE was administered orally at 100 mg/kg or 250 mg/kg for 12 weeks. LBE supplementation regardless of dosage ameliorated plasma levels of hemoglobin A1c (HbA1c) in diabetic mice. Moreover, both LBE supplementations upregulated AMP-activation kinase (AMPK), which may activate sirtuin1 (SIRT) associated pathway accompanied by decreased lipid synthesis at low dose of LBE supplementation. These changes were in part explained by reduced protein levels of oxidative stress (nuclear factor erythroid 2-related factor 2 (Nrf2) and catalase), inflammation (nuclear factor kappa B (NF-κB), interleukin-1β (IL-1β), interleukin-6 (IL-6), and nitric oxide synthases (iNOS)), and fibrosis (α-smooth muscle actin (α-SMA) and protein kinase C (PKC)) in diabetic liver. Taken together, LBE might be a potential nutraceutical to ameliorate hepatic damage by regulation of AMPK associated pathway via oxidative stress, inflammation, and fibrosis in T2DM.

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Section: Discussionmentioning

confidence: 53%

Effects of Lespedeza Bicolor Extract on Regulation of AMPK Associated Hepatic Lipid Metabolism in Type 2 Diabetic Mice

et al. 2019

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“…And blood stasis, as discussed above, is considered by TCM a significant pathogenetic mechanism of pDPN. Recently, it demonstrated that the extracts of Spatholobi Caulis have neuroprotective effects and inhibit the effects of diabetes-induced glucotoxicity for its improvement in apoptotic phenotypes and oxidative stress [41,42]. Paeoniae Radix Alba is known for its analgesic activity and has been widely used to treat pain-related diseases with Glycyrrhizae Radix; it has been recently explored that the combination of two herbs possesses an obvious analgesic and antiinflammatory effect and the potential molecular mechanism might be due to the increasing expression and function of transient receptor potential ion channel protein vanilloid receptor 1 (TRPV1) channel [43].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study

Zheng

Fan

Lin

et al. 2019

Journal of Diabetes Research

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Painful diabetic peripheral neuropathy (pDPN) is a debilitating complication of diabetes. The aim of this retrospective study was to investigate the effectiveness of a Chinese herbal medicine regimen—the modified Huangqi Guizhi Wuwu Decoction (HGWD)—in the treatment of moderate-severe pDPN. The primary objective was to estimate the improvement in neuropathic pain severity. The secondary objective was to assess the response of common symptoms to the treatment. The change in patients’ blood glucose level during the whole treatment was also evaluated. By searching through our medical records of all the diabetic patients from January 2006 to January 2012, we identified and enrolled 30 moderate and severe pDPN patients in the study, for whom the treatment of neuropathic pain by regular pharmacotherapies had failed. The modified HGWD treatment was administered orally twice a day for 6 months. The numerical rating scale (NRS) level at month 6 was 2.57±2.30, significantly improved compared with the baseline level of 6.03±1.83 (P<0.05). The amelioration of 3 common symptoms, namely, limb pain, limb numbness, and insomnia, was evident, and the major response of common symptoms at month 6 including limb pain, insomnia, and limb coldness was significantly increased compared with the results at month 3 (P<0.05). Moreover, 2-hour postprandial blood glucose (2hPG) level decreased from 10.77±1.29 mmol/L at baseline to 9.66±0.60 mmol/L at month 6 (P<0.05). No serious adverse events occurred throughout the treatment period. The modified HGWD was effective in the treatment of moderate and severe pDPN and can thus be offered as a new alternative treatment option for pDPN patients who failed to respond to regular pharmaceutical therapies.

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“…The AGE cross-link breaking and inhibition assay was performed according to a method described previously [30]. For the AGEscollagen cross-link breaking analysis, 1 mg/mL of peroxidase labeled MG-BSA was pre-incubated in collagen-coated 96-well plates at 37°C for 4 h. Thereafter 1 mM of ALT-711 or S. aromaticum (50, 100, and 200 µg/mL) was added and incubation was done for 24 h. To confirm the inhibitory activity of S. aromaticum extract on AGEs-collagen cross-link formation, 1 mg/mL of peroxidase-labeled MG-BSA was incubated in the presence or absence of AG or S. aromaticum (50, 100, and 200 µg/mL) in collagen-coated 96-well plates at 37°C for 24 h. The cross-link breaking and inhibitory activities of S. aromaticum were detected using tetramethylbenzidine substrate on a microplate reader at a wavelength 450 nm.…”

Section: Age Cross-link Breaking and Inhibitory Activity Of S Aromatmentioning

confidence: 99%

Syzygium aromaticum Reduces Diabetes-induced Glucotoxicity via the NRF2/Glo1 Pathway

Choi

Kim

et al. 2020

Planta Med

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AbstractAdvanced glycation end products and methylglyoxal are known to show increased levels in diabetic conditions and induce diverse metabolic disorders. However, the antiglycation ability of the bark of Syzygium aromaticum is not yet studied. In this study, we determined the inhibitory effects of S. aromaticum on AGE formation. Moreover, S. aromaticum showed breakage and inhibitory ability against the formation of AGE-collagen crosslinks. In SV40 MES13 cells, treatment with the S. aromaticum extract significantly ameliorated MG-induced oxidative stress as well as cytotoxicity. Furthermore, in the S. aromaticum extract-treated group, there was a reduction in levels of several diabetic markers, such as blood glucose, kidney weight, and urinary albumin to creatinine ratio in streptozotocin-induced diabetic rats. Treatment with the S. aromaticum extract significantly increased the expression of nuclear factor erythroid 2-related factor 2, a transcription factor involved in the expression of antioxidant enzymes. Moreover, the treatment significantly upregulated the expression of glyoxalase 1 and downregulated the expression of receptor for AGEs. These results suggest that the S. aromaticum extract might ameliorate diabetes-induced renal damage by inhibiting the AGE-induced glucotoxicity and oxidative stress through the Nrf2/Glo1 pathway.

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Spatholobus suberectus Ameliorates Diabetes-Induced Renal Damage by Suppressing Advanced Glycation End Products in db/db Mice

Cited by 23 publications

References 38 publications

Effects of Lespedeza Bicolor Extract on Regulation of AMPK Associated Hepatic Lipid Metabolism in Type 2 Diabetic Mice

Effects of Lespedeza Bicolor Extract on Regulation of AMPK Associated Hepatic Lipid Metabolism in Type 2 Diabetic Mice

Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study

Syzygium aromaticum Reduces Diabetes-induced Glucotoxicity via the NRF2/Glo1 Pathway

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