Spastic Paraplegia Type 30 Associated with Levodopa‐Responsive Parkinsonism

Gallagher, Amy; Fearon, Conor; Smith, Kathryn A.; Lynch, Timothy

doi:10.1002/mdc3.13815

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Despite Spastic paraplegia type 4 being the most frequent form of HSP, recent studies have shown the emergence of parkinsonism as one of the symptoms to investigate, especially in SPG7 and SPG11, two HSPs with autosomal recessive transmission [ 60 , 61 ]. In addition, there are also reports of parkinsonism in other HSP variants, such as Spastic paraplegia type 30 (involving the KIF1A gene) and Spastic paraplegia type 35 (involving the FA2H gene), although these are less common [ 62 , 63 ].…”

Section: Hereditary Spastic Paraplegiasmentioning

confidence: 99%

Parkinsonism in complex neurogenetic disorders: lessons from hereditary dementias, adult-onset ataxias and spastic paraplegias

Aloisio,

Satolli,

Bellini

et al. 2023

Neurol Sci

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Parkinsonism is a syndrome characterized by bradykinesia in combination with either rest tremor, rigidity, or both. These features are the cardinal manifestations of Parkinson’s disease, the most common cause of parkinsonism, and atypical parkinsonian disorders. However, parkinsonism can be a manifestation of complex neurological and neurodegenerative genetically determined disorders, which have a vast and heterogeneous motor and non-motor phenotypic features. Hereditary dementias, adult-onset ataxias and spastic paraplegias represent only few of this vast group of neurogenetic diseases. This review will provide an overview of parkinsonism’s clinical features within adult-onset neurogenetic diseases which a neurologist could face with. Understanding parkinsonism and its characteristics in the context of the aforementioned neurological conditions may provide insights into pathophysiological mechanisms and have important clinical implications, including diagnostic and therapeutic aspects.

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