“…It should be stressed, however, that the use of enemas for the treatment of constipation in all megacolonic cases may be followed by sudden and unexplained fatal collapse. 16 Tap water used for enemas may produce an unheralded waler intoxication and a fatal electrolytic imbalance, especially of sodium. There may occur a sharp fall in the plasma sodium, chloride, and proteins, and an elevation of the plasma volume.…”