Sparse Modeling of Genomic Landscape Identifies Pathogenic Processes and Therapeutic Targets in Metastatic Breast Cancer
Mengchen Pu,
Kai Tian,
Weisheng Zheng
et al.
Abstract:Breast cancer is a heterogeneous disease and ranks as one of the most lethal and frequently detected disease in the world. It poses significant challenges for precision therapy. To better decipher the patterns of heterogeneous nature in human genome and converge them into common functionals, mutational signatures are introduced to define the types of DNA damage, repair and replicative mechanisms that shape the genomic landscape of each cancer patient.In this study, we developed a deep learning (DL) model, Meta… Show more
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