SPARROW reveals cell states and functions influenced by microenvironment zones in complex tissues
Peiyao A Zhao,
Jessica Garber,
Claire Gustafson
et al.
Abstract:Spatially resolved transcriptomics technologies have significantly enhanced our ability to understand cellular characteristics within tissue contexts. However, they present a trade-off between spatial resolution and transcriptome coverage. This limitation, compounded with analytical tools treating cell type inference and cellular neighbourhood identification as separate processes, hinders a unified understanding of tissue features across scales. Our computational framework, SPARROW, infers cell types and delin… Show more
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