Sparfloxacin versus ciprofloxacin for the treatment of community-acquired, complicated skin and skin-structure infections

Lipsky, Benjamin A.; Miller, Bruce; Schwartz, Robert A.; Henry, Dan; Nolan, T.R.; McCabe, A.P.; Magner, David J.; Talbot, George H.

doi:10.1016/s0149-2918(00)88319-8

Cited by 27 publications

(22 citation statements)

References 18 publications

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“…Ciprofloxacin is a broad-spectrum antimicrobial that is used in the treatment of numerous infectious diseases, including those afflicting the skin (Lipsky et al, 1999) (Gogos et al, 1991). It is also a preferred agent for the prevention and treatment of anthrax (Meyerhoff et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, putative ciprofloxacin metabolites were significantly elevated in Oat3(Ϫ/Ϫ) mice. The present findings indicate that polymorphisms of and drug interactions on hOAT3 may influence carboxyfluoroquinolone efficacy, especially in urinary tract infections.Ciprofloxacin is a broad-spectrum antimicrobial that is used in the treatment of numerous infectious diseases, including those afflicting the skin (Lipsky et al, 1999) (Gogos et al, 1991). It is also a preferred agent for the prevention and treatment of anthrax (Meyerhoff et al, 2004).…”

mentioning

confidence: 99%

“…Ciprofloxacin is a broad-spectrum antimicrobial that is used in the treatment of numerous infectious diseases, including those afflicting the skin (Lipsky et al, 1999), bone (Gasem et al, 2003), gastrointestinal tract (Hsieh et al, 1998), genitourinary system (Wagenlehner et al, 2006), lungs (Jones, 2002), and meninges (Gogos et al, 1991). It is also a preferred agent for the prevention and treatment of anthrax (Meyerhoff et al, 2004).…”

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confidence: 99%

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Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

VanWert

Srimaroeng²,

Sweet³

2008

Mol Pharmacol

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Carboxyfluoroquinolones, such as ciprofloxacin, are used for the treatment of numerous infectious diseases. Renal secretion is a major determinant of their systemic and urinary concentration, but the specific transporters involved are virtually unknown. In vivo studies implicate the organic anion transporter (OAT) family as a pivotal component of carboxyfluoroquinolone renal secretion. Therefore, this study identified the specific renal basolateral OAT(s) involved, thereby highlighting potential sources of carboxyfluoroquinolone-drug interactions and variable efficacy. Two heterologous expression systems, Xenopus laevis oocytes and cell monolayers, were used to determine the roles of murine and human renal basolateral mOat1/hOAT1 and mOat3/hOAT3. Ciprofloxacin was transported by mOat3 in both systems (K m value, 70 Ϯ 6 M) and demonstrated no interaction with mOat1 or hOAT1. Furthermore, ciprofloxacin, norfloxacin, ofloxacin, and gatifloxacin exhibited concentration-dependent inhibition of transport on mOat3 in cells with inhibition constants of 198 Ϯ 39, 558 Ϯ 75, 745 Ϯ 165, and 941 Ϯ 232 M, respectively. Ciprofloxacin and gatifloxacin also inhibited hOAT3. Thereafter, in vivo elimination of ciprofloxacin was assessed in wild-type and Oat3 null mice [Oat3(Ϫ/Ϫ)]. Oat3(Ϫ/Ϫ) mice exhibited significantly elevated plasma levels of ciprofloxacin at clinically relevant concentrations (P Ͻ 0.05, male mice; P Ͻ 0.01, female mice). Oat3(Ϫ/Ϫ) mice also demonstrated a reduced volume of distribution (27%, P Ͻ 0.01, male mice; 14%, P Ͻ 0.01, female mice) and increased area under the concentration-time curve (25%, P Ͻ 0.05, male mice; 33%, P Ͻ 0.01, female mice). Female Oat3(Ϫ/Ϫ) mice had a 35% (P Ͻ 0.01) reduction in total clearance of ciprofloxacin relative to wild type. In addition, putative ciprofloxacin metabolites were significantly elevated in Oat3(Ϫ/Ϫ) mice. The present findings indicate that polymorphisms of and drug interactions on hOAT3 may influence carboxyfluoroquinolone efficacy, especially in urinary tract infections.Ciprofloxacin is a broad-spectrum antimicrobial that is used in the treatment of numerous infectious diseases, including those afflicting the skin (Lipsky et al., 1999) (Gogos et al., 1991). It is also a preferred agent for the prevention and treatment of anthrax (Meyerhoff et al., 2004). Its mechanism of action is through the effective inhibition of DNA gyrase, thus preventing DNA replication in susceptible bacteria (Gellert et al., 1977;Sugino et al., 1977). Ciprofloxacin is a carboxylic acidcontaining fluoroquinolone (carboxyfluoroquinolone) that undergoes renal and hepatic elimination, with ϳ50% (oral) or ϳ80% (intravenous) appearing in the urine as parent compound and metabolites 24 h after administration in humans (Höffken et al., 1985). Approximately 20 to 40% of circulating Article, publication date, and citation information can be found at http://molpharm.aspetjournals.org. doi:10.1124/mol.107.042853.ABBREVIATIONS: LLC-PK 1 , porcine kidney cells; AUC, area under the concentration-t...

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

VanWert

Srimaroeng²,

Sweet³

2008

Mol Pharmacol

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“…These characteristics include a broad spectrum of activity, rapid bactericidal action and adequate tissue concentrations at skin and deep tissue sites [6][7][8][9][10][11]. Specifically, moxifloxacin has broad-spectrum in vitro activity against common pathogens implicated in both uncomplicated and complicated skin and skin structure infections [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Sequential intravenous/oral moxifloxacin versus intravenous piperacillin-tazobactam followed by oral amoxicillin-clavulanate for the treatment of complicated skin and skin structure infection

Giordano

Song

Pertel

et al. 2005

International Journal of Antimicrobial Agents

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“…Bacteriological eradication rate was found to be 87% with sparfloxacin and 79.9% with ciprofloxacin. [24] In another study on experimental skin infection by Gisby and Bryant, oral and topical mupirocin applications were compared on a wound model infected with S. aureus or S. pyogenes on rats similar to ours. [13] Mupirocin and fusidic acid were used in local treatment and erythromycin, cephalexin, floxacillin in systemic treatment.…”

Section: Berry Et Al Created a Saturated Wound Model Infected Withmentioning

confidence: 85%

The Effects of Oral Antibiotics on Infection Prophylaxis in Traumatic Wounds

Erbil¹,

Ersoy²,

Özkütük³

et al. 2014

Ulus Travma Acil Cerrahi Derg

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Sparfloxacin versus ciprofloxacin for the treatment of community-acquired, complicated skin and skin-structure infections

Cited by 27 publications

References 18 publications

Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

Sequential intravenous/oral moxifloxacin versus intravenous piperacillin-tazobactam followed by oral amoxicillin-clavulanate for the treatment of complicated skin and skin structure infection

The Effects of Oral Antibiotics on Infection Prophylaxis in Traumatic Wounds

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