Spanish Society for Pediatric Infectious Diseases guidelines on tuberculosis in pregnant women and neonates (ii): Prophylaxis and treatment

Baquero-Artigao, Fernando; Peña, María José; Rabes, T. del Rosal; Julian, Antoni Noguera; Mellgren, Åsa; Fernández-Miranda, María de la Calle; Gómez, María Luisa Navarro

doi:10.1016/j.anpede.2015.09.002

Cited by 1 publication

(2 citation statements)

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“… 14 However, pyridoxine supplements (1–2 mg/kg) are still recommended for breastfed infants if the mother uses INH. 17 , 18 …”

Section: Discussionmentioning

confidence: 99%

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Severe neutropenia in a breastfed infant: a case report and discussion of the differential diagnosis

Broek¹,

Bosch²,

Cortoos³

et al. 2018

IMCRJ

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Neonatal neutropenia is regularly seen with variable etiology. We describe a breastfed infant with maternal medication use as a probable cause of neonatal neutropenia. An 8 days old exclusively breastfed female infant of Arab-Berber descent was referred to our hospital because of an infection of the umbilicus. Complete blood count showed a picture of severe isolated neutropenia. After initiating intravenous antibiotic treatment, the infection quickly resolved, but the isolated neutropenia persisted. Bone marrow aspiration indicated severe congenital neutropenia. The mother was known to have Crohn’s disease, treated with methylprednisolone and adalimumab up to 3 months before delivery, and latent tuberculosis, for which she used isoniazid postnatally. Breast-feeding was terminated and filgrastim was started, with an increase of the neutrophilic count. After several weeks, filgrastim could be terminated. Bone marrow and complete blood count were repeated and were completely normal. This case report describes a very young breastfed female infant with severe neutropenia, causing an infection, in which maternal adalimumab use could not be excluded as a possible cause. Maternal isoniazid use is highly unlikely.

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“… 14 However, pyridoxine supplements (1–2 mg/kg) are still recommended for breastfed infants if the mother uses INH. 17 , 18 …”

Section: Discussionmentioning

confidence: 99%

“… 14 Toddywalla et al 19 reported that INH is capable of suppressing hepatic drug metabolizing activity in infants of mothers on chronic therapy, and Pariente-Khayat et al 20 reported that the maturation of N-acetyltransferase 2, which is the main route of metabolizing INH, 14 occurs in the first 4 years of life. 14 , 17 , 20 …”

Section: Discussionmentioning

confidence: 99%