Spanish Pacemaker Registry. 17th Official Report of the Section on Cardiac Pacing of the Spanish Society of Cardiology (2019)

Jiménez, Marta Pombo; Pérez, Óscar Cano; García, José González; Bertomeu-González, Vicente

doi:10.1016/j.rec.2020.09.010

Cited by 6 publications

(18 citation statements)

References 21 publications

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“…Actually, there was no missing data on most of the parameters analysed in this study. In contrast to that, other publications from registry data report missing data for some studied parametersas much as 49% of the patients regarding symptoms prior to implantation and even up to 65% regarding etiology of the conduction disturbance [4].…”

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confidence: 68%

“…Европейската Асоциация по Аритмии (EHRA) и Европейското Кардиологично Дружество (ESC) редовно публикуват данни относно броя и типa имплантирани електронни устройства в отделните страни членки [1,2]. Някои национални дружества също са публикували обзор на дейността си, базиран на данни от локални или национални регистри и бази данни [3,4]. Въпреки дългогодишния опит с имплантируемите електронни устройства в нашата страна до момента не са публикувани систематизирани данни, които да дадат широк поглед върху електрокардиостимулацията в България.…”

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“…The European Heart Rhythm Association (EHRA) and the European Society of Cardiology (ESC) publish data regarding the number and the type of implanted CIEDs in the member states on a regular basis [1,2]. Some national societies have also published data on the volume and type of implanted CIEDs [3,4]. Despite significant experience with CIEDs in our country no systematic data providing an overview of pacing in the country has been published so far.…”

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confidence: 99%

“…На практика в регистъра няма липсващи данни за повечето изследвани в това проучване показатели. За сравнение други автори, публикуващи данни от регистри докладват липсващи данни в до 49% от пациентите по отношение на някои показатели, като симптоматика преди имплантацията или дори до 65% от пациентите по отношение на етиологията на проводното нарушение [4].…”

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“…По отношение на демографските характеристики на пациентите прави впечатление, че най-голям е дялът на имплантираните пациенти във възрастовата група от 70 до 79 години като предоминира мъжкият пол. Възрастовото разпределение се различава от вече публикуваните данни от испанския регистър по електрокардиостимулация, където най-голям дял са имали имплантациите във възрастовата група 80-89 години [4]. Едно потенциално VDD) predominated (used in more than 55% of all cases) as compared to VVI in all types of conduction disturbances.…”

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Cardiac implantable electronic devices in Bulgaria: results from the electronic registry BG-Pace for the period 2019-2021

Traykov¹,

Iovev²,

Borisov³

et al. 2021

Bulgarian Cardiology

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The current study analyses the activity in cardiac pacing in Bulgaria in 2019, 2020 and 2021 based on data derived from a national registry of patients with cardiac electronic implantable devices (CIEDs). Materials and methods. Data from the national registry BG-Pace in the period 08.2019-06.2021 was retrospectively studied. Demographic data, procedure and device type, pacing mode, etiology, symptoms, preimplantation ECG, number of implantations and centre and operator volumes were analysed. Results. Six thousand nine hundred forty-nine devices were implanted by 47 operators in 28 centres for the study period. Median age was 75 (IQR 68-81, 21-103) years in males and 77 (IQR 71-82, 17-98) years in females, P< 0.05. The largest number of devices were implanted in the age group 70-79 years. The most commonly implanted CIEDs were antibradycardia devices with a total of 486.7/million implantations for the period 08.2019-08.2020 and 353.9/million for the period 08.2020-06.2021. Implanted cardioverter-deﬁbrillators demonstrated a growth from 14.1/million to 20.1/million in the period 08.2020 – 06.2021. The number of all implantations dropped signiﬁ cantly during the two epidemic waves of COVID-19. The mean number of implantations per centre and per operator for the whole period was 232.3±204 (2-705) and 148±139.1 (2-660), respectively. Dual chamber device implantations were more prevalent, representing 65.8% of implantations in AV block I and II degree, 63.5% in complete AV block, 59.8% in intraventricular conduction disturbances and 60.9% in sick sinus syndrome. Pacing modes with atrial sensing represented more than 55% of the implantations for all indications. Increasing age was associated with signiﬁ cantly more common use of VVI pacing mode (P < 0.001). Conclusion. The national registry BG-Pace includes systematic clinical, demographical and procedural data for CIED implantations in Bulgaria. Results demonstrate lower number of implantations compared to the average European volume. There was a signiﬁ cant drop in the implantation rate during the two waves of COVID-19.

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confidence: 68%

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confidence: 99%

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Cardiac implantable electronic devices in Bulgaria: results from the electronic registry BG-Pace for the period 2019-2021

Traykov¹,

Iovev²,

Borisov³

et al. 2021

Bulgarian Cardiology

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Permanent pacemaker implantation late after transcatheter aortic valve implantation

et al. 2021

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Role of genetic testing in young patients with idiopathic atrioventricular conduction disease

et al. 2022

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Aims To investigate the role of genetic testing in patients with idiopathic atrioventricular conduction disease requiring pacemaker (PM) implantation before the age of 50 years. Methods and results All consecutive PM implantations in Southern Switzerland between 2010 and 2019 were evaluated. Inclusion criteria were: (i) age at the time of PM implantation: < 50 years; (ii) atrioventricular block (AVB) of unknown aetiology. Study population was investigated by ajmaline challenge and echocardiographic assessment over time. Genetic testing was performed using next-generation sequencing panel, containing 174 genes associated to inherited cardiac diseases, and Sanger sequencing confirmation of suspected variants with clinical implication. Of 2510 patients who underwent PM implantation, 15 (0.6%) were young adults (median age: 44 years, male predominance) presenting with advanced AVB of unknown origin. The average incidence of idiopathic AVB computed over the 2010–2019 time window was 0.7 per 100 000 persons per year (95% CI 0.4–1.2). Most of patients (67%) presented with specific genetic findings (pathogenic variant) or variants of uncertain significance (VUS). A pathogenic variant of PKP2 gene was found in one patient (6.7%) with no overt structural cardiac abnormalities. A VUS of TRPM4, MYBPC3, SCN5A, KCNE1, LMNA, GJA5 genes was found in other nine cases (60%). Of these, three unrelated patients (20%) presented the same heterozygous missense variant c.2531G > A p.(Gly844Asp) in TRPM4 gene. Diagnostic re-assessment over time led to a diagnosis of Brugada syndrome and long-QT syndrome in two patients (13%). No cardiac events occurred during a median follow-up of 72 months. Conclusion Idiopathic AVB in adults younger than 50 years is a very rare condition with an incidence of 0.7 per 100 000 persons/year. Systematic investigations, including genetic testing and ajmaline challenge, can lead to the achievement of a specific diagnosis in up to 20% of patients. Heterozygous missense variant c.2531G > A p.(Gly844Asp) in TRPM4 gene was found in an additional 20% of unrelated patients, suggesting possible association of the variant with the disease.

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Spanish Pacemaker Registry. 17th Official Report of the Section on Cardiac Pacing of the Spanish Society of Cardiology (2019)

Cited by 6 publications

References 21 publications

Cardiac implantable electronic devices in Bulgaria: results from the electronic registry BG-Pace for the period 2019-2021

Cardiac implantable electronic devices in Bulgaria: results from the electronic registry BG-Pace for the period 2019-2021

Permanent pacemaker implantation late after transcatheter aortic valve implantation

Role of genetic testing in young patients with idiopathic atrioventricular conduction disease

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