Crew performance is highly dependent on spacecraft design and operational interactions and influenced by various spaceflight environmental parameters. Current human space mission design processes are challenged to include the full range of impacts on crew performance prediction, either positive or negative, which can affect the accuracy in analysis of safety-critical tasks and overall operation of the system. The purpose of this study is to present a framework that integrates design assessment and operational efficiency factors with three composite crew performance metrics intended to provide a more human-centric methodology for evaluating spacecraft design options. To develop such a framework, a systematic approach was first taken to identify, categorize, and organize terms associated with crew performance. Performance measurement techniques and implementation philosophies were assessed from analogous industries to gain insight from the broader, terrestrial knowledge base. Various terms, definitions, and methods from this context were aggregated into the proposed spaceflight crew performance framework, as applicable. This framework is intended to be used as a guide for designers as a predictive means to assess how effectively the system accommodates and utilizes the crew through standardized performance feedback data.