Space-time clustering analyses of childhood acute lymphoblastic leukaemia by immunophenotype

Abstract

Space-time clustering analyses of acute lymphoblastic leukaemia in children, by immunophenotype, were carried out using a population-based registry. Significant evidence was found of space-time clustering for cases of the precursor B-cell sub-type, in the childhood peak, based on time and location at birth.

Detection of CD10, CD34 and their combined expression on Childhood Acute Lymphoblastic Leukemia and the association with clinical outcome in Indonesia

“…This result is similar to our previous study [24]. Compared to studies in high income and low-income countries our finding is relatively high for T-lineage ALL [25][26][27][28][29][30][31][32][33][34][35]. Expression of CD10 and CD34 also varies in different studies ( Table 1).…”

Spatial and space–time clustering of childhood acute leukaemia in France from 1990 to 2000: a nationwide study

“…A space -time interaction between dates and places of diagnoses of ALL has often been reported within small temporal and spatial distances (Glass et al, 1971;Draper, 1991;Gilman and Knox, 1991;Gilman et al, 1999;Birch et al, 2000;Akhtar et al, 2005), especially among young children (Glass et al, 1971;Gilman et al, 1999;Birch et al, 2000). Birch et al also evidenced a space -time interaction between the dates of diagnoses and the places of birth, while McNally et al (2002) found a significant interaction between both places and dates of birth for the precursor B-cell subtype of ALL.…”

Spatial clustering and space–time clusters of leukemia among children in Germany, 1987–2007

“…Three studies investigated both [20,21,22]. Four found no spatial clustering and clusters at all [8][9][10][11], four found statistically significant results for at least one subgroup [14,16,21,22], and five found spatial clustering for the overall group of leukemia [12,13,15,17,20]. The five studies which investigated space-time interaction all found statistically significant results [18,19,20,21,22].…”

“…Ten had their focus on clusters [8,9,10] and spatial clustering [11,12,13,14,15,16,17], two on space-time interaction alone [18,19]. Three studies investigated both [20,21,22]. Four found no spatial clustering and clusters at all [8][9][10][11], four found statistically significant results for at least one subgroup [14,16,21,22], and five found spatial clustering for the overall group of leukemia [12,13,15,17,20].…”