Space‐Providing Expanded Polytetrafluoroethylene Devices Define Alveolar Augmentation at Dental Implants Induced by Recombinant Human Bone Morphogenetic Protein 2 in an Absorbable Collagen Sponge Carrier

Wikesjö, Ulf M.E.; Qahash, Mohammed; Thomson, Robert C.; Cook, Alonzo D.; Rohrer, Michael D.; Wozney, John M.; Hardwick, W. Ross

doi:10.1111/j.1708-8208.2003.tb00192.x

Cited by 65 publications

(82 citation statements)

References 38 publications

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“…Nevertheless, rhBMP-2/ACS-induced bone formation exhibited considerably variable geometry; at times only a thin layer of bone wallpapered the root of the threads of the bone-anchoring implant surface. Apparently, the ACS carrier was ineffective to consistently support relevant rhBMP-2 induced bone formation also shown in parallel studies using a panel of rhBMP-2 concentrations (Tatakis et al 2002;Wikesjö et al 2003;Lu et al 2013). This apparent variability in bone formation could have several geneses including rhBMP-2 dose and release kinetics or bioavailability, but also reflect ACS structural integrity, biodegradation, degree of soak-load, or any combination(s) thereof.…”

Section: Alveolar Augmentationmentioning

confidence: 81%

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Alveolar Augmentation: Focus on Growth Factors (BMPs)

Wikesjö

Susin

Lee

2014

Mechanical Engineering Series

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Surgical placement of dental implants is governed by the prosthetic design and the morphology and quality of the alveolar bone. Often, implant placement may be difficult, if at all possible, due to alveolar ridge aberrations. In consequence, prosthetically dictated implant positioning commonly entails bone augmentation procedures. We herein discuss the unique biologic potential, the clinical relevance, and perspectives of bone morphogenetic protein (BMP) technologies (focus on rhBMP-2) for alveolar bone augmentation. We also address merits and short-comings of current treatment protocol including bone biomaterials and guided bone regeneration (GBR). In perspective, our studies suggest that BMPs have an unparalleled, dose-dependent potential to augment alveolar bone and in turn support dental implant fixation and functional loading. Inclusion of BMPs for alveolar augmentation to facilitate dental implant fixation may thus not only enhance predictability of existing clinical protocol but radically change current treatment paradigms making conventional "grafting" and GBR procedures altogether obsolete.

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Section: Alveolar Augmentationmentioning

confidence: 81%

“…Healing interval 8 weeks. From Wikesjö et al (2003Wikesjö et al ( , 2004, figure copyrighted by and modified with permission from Wiley-Blackwell…”

Section: Alveolar Augmentationmentioning

confidence: 99%

Alveolar Augmentation: Focus on Growth Factors (BMPs)

Wikesjö

Susin

Lee

2014

Mechanical Engineering Series

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“…Une autre étude préclinique indique que ACS/rhBMP-2 devrait être mis en place dans la même séance que l'extraction pour plus d'efficacité [45]. Il semblerait que l'on exploite mieux les capacités de l'éponge de collagène chargée en facteur de croissance en l'associant avec une matrice rigide ou du TCP [46][47][48].…”

Section: Discussionunclassified

Intérêt des éponges de collagène pour prévenir la résorption osseuse alvéolaire post-extractionnelle : revue systématique de la littérature

Blanchy

Babilotte

Fénelon

et al. 2016

Med Buccale Chir Buccale

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Résumé -Introduction :La cicatrisation alvéolaire post-extractionnelle est accompagnée systématiquement d'une résorption osseuse plus ou moins importante selon les sites anatomiques et la pathologie initiale. Cette résorption osseuse peut parfois compromettre la mise en place d'implants dentaires. L'objectif de cette revue systématique de la littérature était d'évaluer si les éponges de collagène permettaient de limiter cette résorption osseuse. Matériels et méthodes : Les bases de données Medline et Pubmed ont été consultées pour la période 1986-2015. Résultats : Les études comparant les éponges de collagène à une cicatrisation naturelle n'ont pas montré de différence significative en ce qui concerne la cicatrisation alvéolaire. En revanche, les études comparant l'implantation d'une éponge de collagène comme vecteur de facteurs de croissance à une éponge de collagène seule montraient un effet positif des facteurs de croissance pour corriger un défaut osseux parodontal ou pour limiter la résorption post-extractionnelle. Discussion : Il n'y a pas d'intérêt à placer une éponge de collagène seule dans une alvéole d'extraction pour limiter la résorption osseuse. En revanche, la mise en place dans l'alvéole d'une éponge de collagène associée à des facteurs de croissance permet de maintenir la hauteur et la largeur de la crête alvéolaire. Conclusion : Les éponges de collagène doivent être utilisées uniquement comme des hémostatiques locaux après une extraction dentaire. Rien n'indique dans la littérature que ces éponges pourraient avoir un rôle dans le maintien du volume osseux alvéolaire.Abstract -Use of acellular collagen sponges to prevent post-extraction alveolar bone resorption: systematic review of the literature. Introduction: Alveolar bone healing following dental extraction is usually accompanied by a resorption of alveolar bone. This resorption of alveolar bone may hinder the insertion of dental implants. The aim of this literature review was to evaluate whether acellular collagen sponge (ACS) grafting could limit alveolar bone resorption and maintain alveolar bone volume after dental extraction. Materials and Methods: The Medline and Pubmed databases were searched for the period 1986-2015. Results: Studies comparing ACS grafting with natural healing did not show any significant differences concerning alveolar bone healing and bone volume preservation. Experiments comparing the implantation of ACS alone versus ACS loaded with growth factors such as rh-BMP2 showed better results using rh-BMP2 for guided periodontal regeneration and post-extraction alveolar bone volume preservation. Discussion: This systematic review of the literature shows that there is no evidence that grafting a collagen sponge inside an alveolar socket would limit alveolar bone resorption. On the other hand, the insertion of a collagen sponge loaded with growth factors (such as rhBMP2) allows maintaining the height and width of the alveolar ridge. Conclusion: Acellular collagen sponges must be used as a local haemostatic agent. They have n...

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“…91 Therefore, a collagen-based carrier need to be modified to provide space for bone formation and maturation during the more advanced stages of healing. 92 The combination of collagen with other natural and synthetic materials has also been explored recently and collagen gels, microparticles, and other modified forms of collagen have also been comprehensively reported as carrier vehicles for growth factor delivery in periodontal regeneration. To date, collagen-based devices, including GTR membranes, 42 sponge/hydrogel growth factor delivery vehicles [26][27][28]30,31 and tissue scaffolds, 87,92 hold considerable promise for the future in periodontal regeneration and clinical dental implantation.…”

Section: Collagenmentioning

confidence: 99%

“…127 * a space-providing macroporous expanded polytetrafluoroethylene device, 92 an ACS carrier, 30 and a bioresorbable PLA barrier device (Atrisorb) 168 * a Dex-GMA/gelatin system developed in our previous work. 34,41,95 Growth factor delivery systems are synthesized based on the appropriate materials using different delivery approaches.…”

Section: Growth Factor Delivery Systems and Devicesmentioning

confidence: 99%

Localized delivery of growth factors for periodontal tissue regeneration: Role, strategies, and perspectives

Chen

Shelton

Jin

et al. 2009

Medicinal Research Reviews

131

111

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Difficulties associated with achieving predictable periodontal regeneration, means that novel techniques need to be developed in order to regenerate the extensive soft and hard tissue destruction that results from periodontitis. Localized delivery of growth factors to the periodontium is an emerging and versatile therapeutic approach, with the potential to become a powerful tool in future regenerative periodontal therapy. Optimized delivery regimes and well-defined release kinetics appear to be logical prerequisites for safe and efficacious clinical application of growth factors and to avoid unwanted side effects and toxicity. While adequate concentrations of growth factor(s) need to be appropriately localized, delivery vehicles are also expected to possess properties such as protein protection, precision in controlled release, biocompatibility and biodegradability, self-regulated therapeutic activity, potential for multiple delivery, and good cell/tissue penetration. Here, current knowledge, recent advances, and future possibilities of growth factor delivery strategies are outlined for periodontal regeneration. First, the role of those growth factors that have been implicated in the periodontal healing/regeneration process, general requirements for their delivery, and the different material types available are described. A detailed discussion follows of current strategies for the selection of devices for localized growth factor delivery, with particular emphasis placed upon their advantages and disadvantages and future prospects for ongoing studies in reconstructing the tooth supporting apparatus.

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Space‐Providing Expanded Polytetrafluoroethylene Devices Define Alveolar Augmentation at Dental Implants Induced by Recombinant Human Bone Morphogenetic Protein 2 in an Absorbable Collagen Sponge Carrier

Abstract: The data from this study suggest that a space-providing macroporous ePTFE device defines rhBMP-2/ACS-induced alveolar augmentation to provide adequate bone quantities for implant dentistry. The dental implant surface technology does not appear to substantially influence bone formation.

Cited by 65 publications

References 38 publications

Alveolar Augmentation: Focus on Growth Factors (BMPs)

Alveolar Augmentation: Focus on Growth Factors (BMPs)

Intérêt des éponges de collagène pour prévenir la résorption osseuse alvéolaire post-extractionnelle : revue systématique de la littérature

Localized delivery of growth factors for periodontal tissue regeneration: Role, strategies, and perspectives

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