A n approximately 2-month-old female kitten was examined at The Ohio State University Veterinary Teaching Hospital for severe hypothermia and stupor after being found in a garbage dumpster. Her body temperature on presentation was ,89uF, and she was nonresponsive to stimulation.After resuscitation with warm fluids, IV and intraperitoneal, the kitten's body temperature increased to 99.4uF, but marked neurologic deficits persisted. She was stuporous, with intermittent left torticollis and tetraparesis. Menace response was absent in both eyes (menace response is variable in kittens of this age), with miosis and an elevated left third eyelid. Conscious proprioception was absent in the right thoracic and pelvic limbs, and decreased in the left thoracic and pelvic limbs. Extensor postural thrust was slightly decreased on the left and absent on the right side of the body. Spinal reflexes were normal, with the exception of decreased flexor withdrawal reflexes in the thoracic limbs, worse on the right. Hyperpathia was identified from the mid-to caudalcervical region. The neuroanatomic localization was multifocal, primarily affecting the left forebrain, with involvement of C6-T2 spinal cord segments. Differential diagnoses included toxoplasmosis, cryptococcosis, feline infectious peritonitis, rabies, bacterial meningoencephalomyelitis, congenital neurologic disease, or trauma with hemorrhage into the central nervous system (CNS). Because of the kitten's young age, bacterial meningoencephalomyelitis, congenital disease, or trauma were considered the most likely diagnoses.Interpretation of CBC results revealed a nonregenerative anemia (hematocrit 20%, reference range, 25-46%), with no reticulocytes on the blood smear. The leukocyte count was normal (5. The kitten was admitted to the intensive care unit and given 0.9% NaCl (4.5 mL/kg/h) and clindamycin a (10 mg/kg IV q12h, slowly). Within 12 hours, the kitten began eating on her own, despite continued severe neurologic deficits. On day 2, she was anesthetized with propofol, and atlanto-occipital cerebrospinal fluid (CSF) centesis was performed. After the neck area was clipped for the procedure, small scars consistent with previous bite wounds were observed. CSF was colorless and cloudy, with a protein concentration of 31 mg/dL (reference range, ,20 mg/dL) and 981 white blood cells (WBC)/mL (reference range, ,5 WBC/mL). Interpretation of a WBC differential count revealed 98% neutrophils, 1% large monocytes, and 1% lymphocytes. The neutrophils appeared mildly degenerate, and rare extracellular and intracellular paired rodshaped bacteria were identified (Fig 1). Ceftazidime b (30 mg/kg IV q8h) and dexamethasone c (0.07 mg/kg IV q24h 3 3 days) were added to the therapy. The remaining CSF was submitted for aerobic bacterial culture and universal bacterial polymerase chain reaction (PCR) assay.The kitten developed a fever of 104.4uF on day 3, which resolved within 6 hours. Her serum sodium concentration remained below the normal reference range through day 4, at which time her IV ...