Space Deficits in Parkinson’s Disease Patients: Quantitative or Qualitative Differences from Normal Controls?

Natsopoulos, Dimitris; Bostantzopoulou, M.-S.; Katsarou, Zoe; Grouios, George; Mentenopoulos, G.

doi:10.1155/1993/693805

Cited by 10 publications

(5 citation statements)

References 41 publications

(94 reference statements)

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“…PD degrades movement accuracy under proprioceptive guidance (without visual feedback)[1,29,30]. Individuals with PD also show sensory integration deficits in visually-guided tasks [8,24] and tendencies resembling spatial neglect [7]. Impaired movement adaptation to altered visual feedback has suggested that PD affects sensorimotor integration, leading to spatial processing and motor control deficits [1].…”

Section: Introductionmentioning

confidence: 99%

“…To better understand how tactile feedback may help the affected proprioception of individuals with PD, and also address whether PD affects tactile/proprioceptive integration, like visuomotor integration [1] in visually-guided tasks [8,24] and in cases resembling neglect [7], we compared the performance of individuals with PD to that of age-matched controls in reproducing the orientation of one arm (“cue-arm”) with the other (“report-arm”). Some conditions included a conflicting pattern of static tactile cues (fingertip contact with a stationary surface) and dynamic muscle stretch cues (transcutaneous biceps brachii muscle-spindle vibration, causing dynamic elbow-extension illusions, and t onic v ibration stretch- r eflex muscle contraction (TVR) [9,10]).…”

Section: Introductionmentioning

confidence: 99%

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Tactile/proprioceptive integration during arm localization is intact in individuals with Parkinson's disease

Rabin

Muratori

Svokos

et al. 2010

Neuroscience Letters

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It has been theorized that sensorimotor processing deficits underlie Parkinson's disease (PD) motor impairments including movement under proprioceptive control. However, it is possible that these sensorimotor processing deficits exclude tactile/proprioception sensorimotor integration: prior studies show improved movement accuracy in PD with endpoint tactile feedback, and good control in tactile-driven precision-grip tasks.To determine whether tactile/proprioceptive integration in particular is affected by PD, nine subjects with PD (off-medication, UPDRS motor=19-42) performed an arm-matching task without visual feedback. In some trials one arm touched a static tactile cue that conflicted with dynamic proprioceptive feedback from biceps brachii muscle vibration. This sensory conflict paradigm has characterized tactile/proprioceptive integration in healthy subjects as specific to the context of tactile cue mobility assumptions and the intention to move the arm.We found that the individuals with PD had poorer arm-matching acuracy than age-matched control subjects. However, PD-group accuracy improved with tactile feedback. Furthermore, sensory conflict conditions were resolved in the same context-dependent fashion by both subject groups. We conclude that the somatosensory integration mechanism for prioritizing tactile and proprioception feedback in this task are not disrupted by PD, and are not related to the observed proprioceptive deficits.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tactile/proprioceptive integration during arm localization is intact in individuals with Parkinson's disease

Rabin

Muratori

Svokos

et al. 2010

Neuroscience Letters

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show abstract

“…Furthermore, in the present study, we did not ask participants to perform mirror-image discrimination; therefore, we could not fully confirm whether the patients exhibited an impaired ability to discriminate mirror images. However, Natsopoulos, Bostantzopoulou, Katsarou, Grouios, and Mentenopoulos [ 20 ] previously described impaired immediate memory of mirror image patterns in patients with PD. Future research should be conducted to reveal the mechanisms of mirror image discrimination ability in patients with PD.…”

Section: Discussionmentioning

confidence: 99%

Mirror writing and cortical hypometabolism in Parkinson’s disease

et al. 2022

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Mirror writing (MW) is the production of individual letters, words, or word strings in the reverse direction. Parkinson’s disease (PD) is a progressive neurodegenerative disorder, and high MW rates have been reported in patients with PD. Thus, the present study sought to identify the factors that cause MW in patients with PD. We examined the frequency of MW in patients with PD and investigated the area of the brain where such frequency inversely correlates with reduced regional cerebral metabolic rates of glucose (rCMRglc). We also examined whether this area satisfied the motor and visual monitoring hypotheses of MW that have been presented in previous studies. Thirty-six subjects with idiopathic PD and 23 healthy controls were included in the study. We asked the participants to write down words, numerals, and sentences from left to right using their dominant and non-dominant hands. Patients with PD underwent an 18F-fluorodeoxyglucose positron emission tomography scan to measure the rCMRglc. Neither the patients with PD nor the healthy subjects exhibited MW in the use of the right hand. In the use of the left hand, MW occurred in 15 of the 36 patients with PD, but in none of the healthy controls. The right intraparietal sulcus was identified as the area where rCMRglc was inversely correlated with the number of left–right reversed characters. Previous functional imaging studies have suggested that the right superior parietal cortex and intraparietal sulcus play an important role in recognizing left–right reversed letters. Therefore, dysfunction in the intraparietal sulcus may hinder the recognition of left–right reversed characters, resulting in MW. Consequently, our findings in patients with PD are consistent with the visual-monitoring hypothesis of MW.

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“…It was reported that patients with PD yield more errors when making 3D judgments ( Trick et al, 1994 ; Maschke et al, 2006 ; Kim et al, 2011 ). Patients with PD were notably impaired in spatial orientation (left–right and front–back), immediate visual-spatial recognition memory for mirror image patterns, 3D constructional skills, visual-spatial attention, and 3D mental rotation ( Natsopoulos et al, 1993 ). Multiple factors in the central and peripheral visual pathway may work congruently in contributing to the pathology of depth perception in PD.…”

Section: Introductionmentioning

confidence: 99%

Stereopsis and Eye Movement Abnormalities in Parkinson’s Disease and Their Clinical Implications

Sang

et al. 2022

Front. Aging Neurosci.

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BackgroundParkinson’s disease (PD) is not exclusively a motor disorder. Among non-motor features, patients with PD possess sensory visual dysfunctions. Depth perception and oculomotor deficits can significantly impact patients’ motor performance. Stereopsis and eye behavioral study using 3D stimuli may help determine their implications in disease status.ObjectiveThe objective of this study is to investigate stereopsis and eye movement abnormalities in PD with reliable tools and their correlation with indicators of PD severity. We hypothesize that patients with PD exhibit different eye behaviors and that these differences may correlate to the severity of motor symptoms and cognitive status.MethodsControl and PD participants were first evaluated for visual acuity, visual field, contrast acuity, and stereo perception with 2D and Titmus stereotests, followed by the assessment with a 3D active shutter system. Eye movement behaviors were assessed by a Tobii X2-60 eye tracker.ResultsScreening visual tests did not reveal any differences between the PD and control groups. With the 3D active shutter system, the PD group demonstrated significantly worse stereopsis. The preserved cognitive function was correlated to a more intact stereo function. Patients with PD had longer visual response times, with a higher number of fixations and bigger saccade amplitude, suggesting fixation stabilization difficulties. Such changes showed a positive correlation with the severity of motor symptoms and a negative correlation with normal cognitive status.ConclusionWe assessed stereopsis with a 3D active shutter system and oculomotor behaviors with the Tobii eye tracker. Patients with PD exhibit poorer stereopsis and impaired oculomotor behaviors during response time. These deficits were correlated with PD motor and cognitive status. The visual parameters may potentially serve as the clinical biomarkers for PD.

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Space Deficits in Parkinson’s Disease Patients: Quantitative or Qualitative Differences from Normal Controls?

Cited by 10 publications

References 41 publications

Tactile/proprioceptive integration during arm localization is intact in individuals with Parkinson's disease

Tactile/proprioceptive integration during arm localization is intact in individuals with Parkinson's disease

Mirror writing and cortical hypometabolism in Parkinson’s disease

Stereopsis and Eye Movement Abnormalities in Parkinson’s Disease and Their Clinical Implications

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