Sp895pacap Deficiency as a Cause of Increased Platelet Aggregability in Idiopathic Nephrotic Syndrome

Eneman, Benedicte; Freson, Kathleen; Heuvel, Lambert vanden; Hoyweghen, Elke Van; Collard, Laure; Walle, Johan Vande; Geet, Chris Van; Levtchenko, Elena

doi:10.1093/ndt/gfv203.33

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“…In nephrotic syndrome patients, parallel loss of urine PACAP and decreased plasma PACAP levels was detected. Interestingly, after bilateral nephrectomy, plasma PACAP levels normalized in parallel with the normalization of elevated platelet counts (105). An earlier human study showed decreased PACAP levels in chronic hepatitis B patients compared to healthy controls, which diminished after antiviral therapy (106).…”

Section: Diseases Of the Gastrointestinal Tract And The Kidneymentioning

confidence: 86%

Role of endocrine PACAP in age-related diseases

et al. 2023

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Pituitary adenylate cyclase activating polypeptide (PACAP) is a conserved neuropeptide, which confers diverse anti-aging endocrine and paracrine/autocrine effects, including anti-apoptotic, anti-inflammatory and antioxidant action. The results of the in vivo and in vitro experiments show that increasing emphasis is being placed on the diagnostic/prognostic biomarker potential of this neuropeptide in a wide array of age-related diseases. After the initial findings regarding the presence and alteration of PACAP in different body fluids in physiological processes, an increasing number of studies have focused on the changes of its levels in various pathological conditions associated with advanced aging. Until 2016 – when the results of previous human studies were reviewed – a vast majority of the studies had dealt with age-related neurological diseases, like cerebrovascular and neurodegenerative diseases, multiple sclerosis, as well as some other common diseases in elderly such as migraine, traumatic brain injury and post-traumatic stress disorder, chronic hepatitis and nephrotic syndrome. The aim of this review is to summarize the old and the new results and highlight those ‘classical’ and emerging clinical fields in which PACAP may become subject to further investigation as a diagnostic and/or prognostic biomarker in age-related diseases.

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Section: Diseases Of the Gastrointestinal Tract And The Kidneymentioning

confidence: 86%