Sp728sen Virus Among Egyptian Hemodialysis Patients and Blood Donors

Elkeraie, Ahmed; Elbably, Elsayed; Selim, Heba S.; Hafez, Elsayed E.

doi:10.1093/ndt/gfv200.47

Cited by 1 publication

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“…In this study, there was no statistical significant difference in SENV positivity rates in relation to area of living whether urban or rural, in accordance with ElKeraie et al, (2015) 10 , but more extended surveys may be needed to verify if the type of area can affect the SENV positivity or not. In our study, there was no relationship between SENV positivity and the duration on hemodialysis, in harmony with Eldin and Glzandour, (2011) 19 mentioned that there were high significant positivity rates of SENV in patients with history of blood transfusion.…”

supporting

confidence: 89%

“…8 This result shows that such infection seems to be uncommon among chronic hemodialysis patients who undergo dialysis in Zagazig university hospitals, in accordance with Omar et al, (2008) 9 who reported that SENV did not seem to be a common infection in Egyptian patients and the prevalence of SENV was 13.5% among patients of chronic liver disease not on hemodialysis, 11.1% among patients of chronic liver disease on hemodialysis and 7.1% among healthy controllers. On the other hand, ElKeraie et al, (2015) 10 reported a relatively high (59%) prevalence of SENV among chronic hemodialysis patients in Alexandria university hospitals. Reports from Italy, USA, Germany and Japan have documented a range of infection from 12.8% to 38% in chronic hemodialysis patients.…”

Section: Discussion:-mentioning

confidence: 98%

“…Additionally, the difference in the rate of prevalence of an infectious agent in hemodialysis units may be due to a variation of the universal precautions and standard infection control measures including transfusion practices and hygienic standards which could be found among different hemodialysis units even within the same country or geographical region. 10 reported that the SENV was more prevalent in older patients on long-term hemodialysis. Although 75% of SENV-positive patients in our present study were males, there was no statistical significant difference of SENV prevalence in relation to gender between SENV-positive and -negative patients, the same which In our study, all the 4 SENV-positive patients had normal values of serum aminotransferases, serum albumin, and total bilirubin.…”

Section: Discussion:-mentioning

confidence: 99%

“…In contrary to ElKeraie et al, (2015). 10 Anemia can be explained in such patients as a cause of chronic illness.…”

Section: Discussion:-mentioning

confidence: 99%

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Prevalence and Effect of Sen Virus in Hemodialysis Patients in Zagazig University Nephrology Unit.

Al-Barshomy¹,

Kamal²,

Abohassan³

et al. 2016

IJAR

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Background: Chronic hemodialysis patients are at higher risk of multiple types of infections than other normal population, especially blood-borne. About 5 % of those patients had a full picture of acute hepatitis without known causative agent for this unknown none A-E hepatitis e.g. TTV, GBV-C and SEN virus (SENV), but after thorough investigations, these viruses were discounted as causes of serious hepatitis.SENV is a single-stranded, non-envelped, circular DNA which was considered as a member of circoviridae family, but it has been recently classified in a floating genus named Anellovirus: unclassified Anellovirus which also include Anellovirus PRA1 (felis catus anellovirus PRAI), Anellovirus PRA4 (felis catus anellovirus PRA 4), SEN-V, Small Anellovirus, TTV (transfusion transmitted virus), TTMV (torque teno mini virus) and TTMDV (torque teno midi virus).SENV has nine different genotypes (A to I) with at least 25% divergence in nucleotide sequence. SENV-D and SENV-H genotypes have comparatively higher frequencies in post-transfusion non A-E hepatitis. Additionally SENV-H has been found more frequent in hemodialysis patients. The main route of transmission is parentral via transfusion of blood and its products, however, other routes have been documented such as feco-oral, sexual and vertical transmissions. It can be detected by PCR and has no treatment. Aim of the work:The aim of this study is to screen high risk group i.e. chronic hemodialysis patients and to identify any ability of SENV to induce acute hepatitis or aggravating the already existing chronic hepatitis. Patients and methods:The study included 98 ESRD patients on regular HD screened for SENV and divided in to 2 groups, SENV +ve and SENV -ve groups.The 98 patients were subjected to proper history taking including name, age, sex, occupation, past history of blood transfusion, liver disease and duration of hemodialysis was obtained. Full clinical assessment for relevant clinical signs. Screening for anti-HCV as a marker for HCV and for HBsAg as a marker for HBV as a confirmation for previous virology results recorded in patients' files, liver function tests and complete blood picture. Screening for SENV-DNA by polymerase chain reaction (PCR) and liver ultrasound. Results: prevalence of SENV infection among patients was only 4.1%. In our study, there were no association between the positivity rates of SENV and the demographic data (age-gender-living area), history of blood transfusion, history of previous surgeries, history of co-morbidities (hypertension, diabetes or both), sera status for anti-HCV antibodies and/or HBs Ag or history of past surgery.SENV alone failed to cause any liver insult in those without any liver illness before and negative for anti-HCV and/or HBsAg. Additionally, it failed to exacerbate or initiate liver insult in our patients with positive sera for anti-HCV antibodies.The effect of SENV on hematopoiesis in our patients has not been clearly established and there has not been any statistically significant effect on WBC, hemogl...

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supporting

confidence: 89%

Section: Discussion:-mentioning

confidence: 98%

Section: Discussion:-mentioning

confidence: 99%

“…In contrary to ElKeraie et al, (2015). 10 Anemia can be explained in such patients as a cause of chronic illness.…”

Section: Discussion:-mentioning

confidence: 99%

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