Sp719fractional Excretion Ofsurvivin, Emmprin and MMP-7 in Children With Chronic Kidney Disease

Musiał, Kinga; Bargenda, Agnieszka; Zwołińska, Danuta

doi:10.1093/ndt/gfw179.26

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“…Such a decrease has been also noted in advanced stages of fibrosis compared with the early phase [ 12 ]. Our previous studies in children with advanced CKD revealed increased serum and urinary concentrations of EMMPRIN [ 13 , 14 ]. Tubular macrophage migration inhibitory factor (MIF) has been characterized as an endogenous renoprotective factor, attenuating the progression of kidney damage [ 15 ].…”

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confidence: 99%

Bone Morphogenetic Proteins (BMPs), Extracellular Matrix Metalloproteinases Inducer (EMMPRIN), and Macrophage Migration Inhibitory Factor (MIF): Usefulness in the Assessment of Tubular Dysfunction Related to Chronic Kidney Disease (CKD)

Musiał

Zwołińska

2021

JCM

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Bone morphogenetic proteins (BMP), extracellular matrix metalloproteinases inducer (EMMPRIN), and macrophage migration inhibitory factor (MIF) are known to be closely connected to renal tubule damage by experimental data; however, this has not been analyzed in children with chronic kidney disease (CKD). The aim of this study was to determine their usefulness in the assessment of CKD-related tubular dysfunction. The study group consisted of 61 children with CKD stages 1–5 and 23 controls. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were assessed by ELISA and their fractional excretion (FE) was calculated. The serum and urine concentrations of BMP-2, BMP-6, EMMPRIN, and MIF were significantly elevated in children with CKD vs. controls. The FE of BMP-2, FE BMP-6, and EMMPRIN increased significantly in CKD stages 1–2, but exceeded 1% in CKD stages 3–5. FE MIF became higher than in controls no sooner than in CKD 3–5, but remained below 1%. The FE values for BMP-2, BMP-6, and EMMPRIN of <1% may result from the tubular adaptive mechanisms, whereas those surpassing 1% suggest irreversible tubular damage. The analysis of serum/urinary concentrations and fractional excretion of examined parameters may allow the assessment of CKD-related tubular dysfunction.

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