Sp505serum Vancomycin Levels in Hemodialysis:preleminary Results

Sonikian, Makrouhi; Politis, Panagiotis; Papachrysanthou, Theodora; Tserkezis, Georgios; Paraskevopoulou, Patrina; Parissis, Christoforos

doi:10.1093/ndt/gfw173.09

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2021

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“…Based on the literature review, dosing of vancomycin in adult patients typically calls for administering a loading dose followed by a maintenance dose, with subsequent dialysis sessions to maintain vancomycin serum trough concentrations between 15 and 20 mg/L. 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 However, this recommended therapeutic range is not supported by evidence from clinical trials and lower trough concentrations were associated with an AUC/MIC ≥ 400 hours. 13 , 17 , 18 Only a few studies in adults requiring HD/HDF assessed vancomycin dosing using the AUC/MIC target.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Vancomycin in Pediatric Patients Receiving Intermittent Hemodialysis or Hemodiafiltration

Chung

Tjon

Nemec

et al. 2021

Kidney International Reports

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