Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells

Wu, Dong; Shen, Ruinan; Wang, Qi; Gao, Yuting; Qi, Xia; Jiang, He; Yao, Jiayi; Lin, Xiaolin; Wu, Yun; Wang, Lifu

doi:10.4161/cbt.8.22.9880

Cited by 28 publications

(30 citation statements)

References 23 publications

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“…Since TRF2 is an important element of telomere homeostasis and loss of TRF2 yields end-to-end fusions, telomere shortening, activation of DNA damage pathways, TRF2 regulation could be a contributing factor in cancer progression [4]. In accordance with this hypothesis, TRF2 overexpression is detected in various tumor types like gastric carcinoma, hepato-carcinogenesis or colorectal carcinoma [8][9][10]. Regulation of TRF2 expression was found to be correlated with tumor grade in lung cancer progression [11].…”

Section: Introductionsupporting

confidence: 60%

253: Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients

Orun¹,

Özden²,

Tiber³

et al. 2014

European Journal of Cancer

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Background: Telomeres are protective caps consisted of specific tandem repeats (5′-TTAGGG-3′). Shortening of telomeres at each cell division is known as "mitotic clock" of the cells, which renders telomeres as important regulators of lifespan. TRF2 is one of the critical members of shelterin complex, which is a protein complex responsible from the preservation of cap structure, and loss or mutation of TRF2 results in DNA damage, senescence or apoptosis. Since cancer is frequently associated with aberrant cell cycle progression, defective DNA repair or apoptosis pathways, TRF2 could be one likely candidate for cancer therapy. Here we investigated the prognostic role of TRF2 levels in cervical cancer patients. Fold-induction rates were evaluated with respect to median values after real-time PCR analysis. Overall survival, distant disease-free and local recurrence-free survival rates were calculated using Kaplan-Meier long rank test.

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Section: Introductionsupporting

confidence: 60%

253: Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients

Orun¹,

Özden²,

Tiber³

et al. 2014

European Journal of Cancer

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“…Sp1 is a member of the gene family with sequence-specific DNA-binding C-terminal zinc-finger motifs. It plays a critical role in the regulation of expression of mammalian genes lacking a TATA box by binding to GC/GT boxes to activate transcription (Raynaud et al, 2008;Dong et al, 2009). It has been reported that Sp1 is involved in the development and progression of several types of cancers, including colorectal cancer (Dong et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…It plays a critical role in the regulation of expression of mammalian genes lacking a TATA box by binding to GC/GT boxes to activate transcription (Raynaud et al, 2008;Dong et al, 2009). It has been reported that Sp1 is involved in the development and progression of several types of cancers, including colorectal cancer (Dong et al, 2009). At present, CCND1, PDEGF, p21, VEGF, TGFβ, E2F1, c-fos, OPN, and TGFα are the cancer-related Sp1 targets that have been identified (Gartel et al, 2000;Zhu et al, 2002;Takami et al, 2007;Dong et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that Sp1 is involved in the development and progression of several types of cancers, including colorectal cancer (Dong et al, 2009). At present, CCND1, PDEGF, p21, VEGF, TGFβ, E2F1, c-fos, OPN, and TGFα are the cancer-related Sp1 targets that have been identified (Gartel et al, 2000;Zhu et al, 2002;Takami et al, 2007;Dong et al, 2009). There has been one study on the association of PPARD gene variants with upper aero-digestive tract cancers in patients from Los Angeles, CA, USA (Yang et al, 2014) and another on their association with colorectal cancer in patients from Switzerland (Ticha et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer

Rosales-Reynoso

et al. 2017

Genet. Mol. Res.

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ABSTRACT. PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metabolic syndrome, and type 2 diabetes mellitus. The aim of this study was to determine whether the single nucleotide polymorphism +294T/C (rs2016520) in PPARD is associated with colorectal cancer (CRC) in the Mexican population. Genomic DNA from 178 CRC patients and 97 healthy blood donors was analyzed. The polymorphism was identified by the polymerase chain reaction-restriction fragment length polymorphism method. Results demonstrated that patients with the T/C genotype for the +294T/C (rs2016520) polymorphism present a protective role against CRC [odds ratio (OR) = 0.39; 95% confidence interval (CI) = 0.22-0.69; P = 0.0008]. This association was also evident for the T/C genotype in the stratified analysis by tumor-nodemetastasis stages I+II (OR = 0.26, P = 0.0332) and III+IV (OR = 0.44, P = 0.0067). However, in the stratified analysis by tumor location, we observed an increased risk of rectal cancer (OR = 7.57, P = 0.0403) vs colon cancer (OR = 4.87, P = 0.234) in patients carrying the C/C genotype and under the dominant and recessive models of inheritance.In conclusion, for the first time, the association between the +294T/C (rs2016520) polymorphism and colorectal cancer has been studied in Mexican patients. Our results reveal that variations in PPARD may play a significant role in genetic susceptibility to colorectal cancer.

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“…Telomere repeat binding factor 2 (TRF2) plays a key role in the protective activity of telomere and is overexpression in CRC. Study showed transcription factor Sp1 is also involved in upregulation of TRF2, that is, TRF2 is overexpressed in CRC mediated by Sp1 regulation (Dong et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Seeking colorectal carcinoma related genes based on regulation network

Yang¹

2011

Afr. J. Pharm. Pharmacol.

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Colorectal carcinoma (CRC) is one of the most frequent cancers worldwide with very high mortality. In this study, the microarray data was used to construct a regulation network to identify potential genes related with CRC. The results showed SP1, RELA, STAT1, PPARA and TP53 arise as hub nodes in transcriptome network in accordance with previous studies, and new transcription factors and target genes related with CRC were also identified, such as HIF1A and NFIC both regulated the PFKFB3 in response to CRC. In general, it is demonstrated that transcriptome network analysis is useful in identification of CRC related genes.

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Sp1 upregulates expression of TRF2 and TRF2 inhibition reduces tumorigenesis in human colorectal carcinoma cells

Cited by 28 publications

References 23 publications

253: Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients

253: Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients

Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer

Seeking colorectal carcinoma related genes based on regulation network

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