SP-B and SP-C analogues within CHF5633 synthetic surfactant probed by fluorescence labeling

Ronda, Luca; Faggiano, Serena; Paredi, Gianluca; Michielon, Annalisa; Sartor, Franco; Raschini, Annamaria Soliani; Cavatorta, Valeria; Sgarbi, Elisa; Bettati, Stefano; Mozzarelli, Andrea

doi:10.1016/j.molliq.2019.111983

Cited by 2 publications

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“…16,[43][44][45] Further, the solvatochromic and thermal effects on the uorescence properties of such compounds have attracted remarkable interest. 30,[33][34][35][46][47][48][49][50] In particular, their emission mechanism has been described in terms of 1 L a and 1 L b locally excited states, 30,31,34,40,48 and may involve an intramolecular charge transfer and a mixing of p / p* and n / p* electronic transitions in the naphthalene core and the amino group, respectively. In addition, experimental studies have veried that dansyl derivatives exhibit a signicant Stokes shi as the solvent polarity is increased, [33][34][35]49 with a considerable change in molecular dipole moment.…”

Section: Introductionmentioning

confidence: 99%

Thermal and solvatochromic effects on the emission properties of a thienyl-based dansyl derivative

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Thermal and solvatochromic effects on the emission properties of a thienyl-based dansyl derivative

et al. 2020

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Pulmonary Surfactant: A Unique Biomaterial with Life-saving Therapeutic Applications

Pioselli

Salomone

Mazzola

et al. 2022

CMC

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: Pulmonary surfactant is a complex lipoprotein mixture secreted into the alveolar lumen by type 2 pneumocytes, which is composed by tens of different lipids (approximately 90% of its entire mass) and surfactant proteins (approximately 10% of the mass). It is crucially involved in maintaining lung homeostasis by reducing the values of alveolar liquid surface tension close to zero at end-expiration, thereby avoiding the alveolar collapse, and assembling a chemical and physical barrier against inhaled pathogens. A deficient amount of surfactant or its functional inactivation is directly linked to a wide range of lung pathologies, including the neonatal respiratory distress syndrome. This paper reviews the main biophysical concepts of surfactant activity and its inactivation mechanisms, and describes the past, present and future roles of surfactant replacement therapy, focusing on the exogenous surfactant preparations marketed worldwide and new formulations under development. The closing section describes the pulmonary surfactant in the context of drug delivery. Thanks to its peculiar composition, biocompatibility, and alveolar spreading capability, the surfactant may work not only as a shuttle to the branched anatomy of the lung for other drugs but also as a modulator for their release, opening to innovative therapeutic avenues for the treatment of several respiratory diseases.

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SP-B and SP-C analogues within CHF5633 synthetic surfactant probed by fluorescence labeling

Cited by 2 publications

References 50 publications

Thermal and solvatochromic effects on the emission properties of a thienyl-based dansyl derivative

Thermal and solvatochromic effects on the emission properties of a thienyl-based dansyl derivative

Pulmonary Surfactant: A Unique Biomaterial with Life-saving Therapeutic Applications

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