Abstract:SP-40,40 is an 80-kDa glycoprotein consisting of two 40-kDa subunits (a-chain and b-chain). It is a multi-functional protein which modulates the membrane attack complex of the complement, [1][2][3] causes cell aggregation, 4) accelerates immune complex formation 5) and binds to b-endorphin.6)The induction of SP-40,40 synthesis in the hippocampi of patients with Alzheimer's disease has been reported, 7,8) and we have also reported the incorporation of SP-40,40 into senile plaque.9) It was also reported that SP-… Show more
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