SP-0222: Role of endoluminal brachytherapy for rectal cancer: current status and challenges

Vuong, T.; Niazi, Tamim; Dević, Slobodan

doi:10.1016/s0167-8140(15)40220-8

Cited by 6 publications

(2 citation statements)

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“…Vuong et al have used brachytherapy boosts (30 Gy delivered in three treatment sessions) in addition to external beam radiotherapy (40 Gy in 16 fractions) for treatment of patients unfit for surgery, and have achieved local control in 73 % of patients at 2 years [47]. Marijnen et al conducted a dose-finding study (the HERBERT trial [48]), where they combined 39 Gy in 13-fraction external beam radiotherapy with three brachytherapy boost treatments.…”

Section: Endocavitary Brachytherapymentioning

confidence: 99%

“…The data point for Habr-Gama et al[29••] is based on the newest publication from the Brazilian group; radiotherapy was reported as B50.4-54 Gy^, and hence the average (52.2 Gy) has been used. Vuong et al[47] is based on data for medically inoperable patients treated with combined external beam and brachytherapy, which are only published in abstract form. The radiotherapy regimen consisted of 40 Gy in 15 fractions delivered with external beam radiotherapy, as well as 30 Gy brachytherapy given weekly in three fractions.…”

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confidence: 99%

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Radiation Techniques for Increasing Local Control in the Non-Surgical Management of Rectal Cancer

Appelt

Jakobsen

2015

Curr Colorectal Cancer Rep

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A fraction of patients with rectal cancer can achieve clinical complete response following longcourse chemoradiotherapy (CRT), and there is accumulating clinical evidence that these patients can be managed non-surgically with acceptable oncological outcome. Consequently, strategies for increasing the proportion of complete responders are actively being explored. Some, although limited, experience with high-dose radiotherapy indicates that there might exist a dose-response relationship for local tumour control after radiotherapy alone. Thus, tumour dose escalation could be indicated for selected patients, particularly in cases with small tumours and limited local disease. This report discusses several radiotherapy techniques for tumour boosting, focusing on technical challenges and clinical experiences with each technique. Specifically, external beam radiotherapy, brachytherapy and contact X-ray treatment for dose escalation are considered. Ultimately, no technique provides definitive advantage over others, and the choice in clinical practice will have to depend on the patient population treated as well as the technical capabilities of the treating department.

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Section: Endocavitary Brachytherapymentioning

confidence: 99%

mentioning

confidence: 99%