Sozialstaatlichkeit Und Neoliberale Gesellschaftsordnung

Per-2,3-O-alkylatedβ-cyclodextrin duplexes connected with disulfide bonds

“…We presumed that permethylation of all secondary hydroxyls at both peripheries of the duplexes could lead to much higher solubility as deduced from the known effect of permethylation of native CDs (6). Furthermore, we intended to introduce suitable reactive moieties, such as allyl groups, that could be later converted to various functional groups such as carboxyls or amines and, in this way, increase binding affinities and selectivities by electrostatic interactions (7). In this paper, we report synthetic methodology allowing preparation of β-CD duplexes permethylated and perallylated at secondary hydroxyls and a preliminary assessment of the binding properties of the former.…”

A γ-cyclodextrin duplex connected with two disulfide bonds: synthesis, structure and inclusion complexes

“…2 It was suggested that the free energy of binding in such host-guest systems is proportional to the surface area of the guest buried upon binding. 3 Since cavities of CDs are relatively shallow (≈6-7 Å) they do not allow complete inclusion of molecules longer than one benzene ring preventing thus a strong binding unless additional attractive interactions, such as ionic 4 or coordination 5 bonding with suitably modified CD hosts, are involved. Consequently, binding affinities of native CDs mostly fall in the 10 2 -10 3 M −1 interval 3,6 limiting the scope of their applications in fields such as drug delivery systems or in supramolecular analytical chemistry, 7 namely in fluorescent indicator displacement assays, 8 operating at low concentrations in a complex biological environment.…”