Soymilk intake has desirable effects on phosphorus and calcium metabolism

Sakuma, Masae; Suzuki, Ayaka; Kikuchi, Minako; Arai, Hidekazu

doi:10.3164/jcbn.17-79

Cited by 9 publications

(16 citation statements)

References 31 publications

(30 reference statements)

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“…Among the factors influencing P and Ca utilization metabolism, a mean Ca:P ratio of 1:1 to 2:1 is recommended for proper utilization of the mineral elements by livestock [43,44]. Dietary Ca:P ratios <1:1 or >7:1 should adversely affect the growth and feed efficiency of livestock [45,46]. In our study, the Ca:P ratio in forage from the healthy area was 2.18:1.…”

Section: Discussionmentioning

confidence: 64%

Response of the Wumeng Sheep to Phosphorus Deprived Environment in the Southwest China

Zhao¹,

Min²,

Shen³

2021

Pol. J. Environ. Stud.

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The objective of this study was to determine the response of the Wumeng sheep on phosphorus (P) deprived range in the Southwest China. Samples of herbage, soil and animal tissue were collected in the studied area. Physiological and biochemical values in blood were examined. The mineral contents were determined in soils, forages and animal tissues (blood, bone, wool). The results showed that P contents in soil and forage from P-deprived pastures were markedly lower than those in healthy ranges (P<0.01) and the ratio of calcium (Ca) to P in the P-deprived forages was 11.49:1. P contents in blood, wool, rib, hip, and teeth from P-deprived Wumeng sheep were also markedly lower than those in healthy sheep (P<0.01). Compared with healthy sheep, the levels of hemoglobin and packed cell volume from P-deficient sheep were significantly lower than those in healthy animals (P<0.01). The levels of creatinine (CRT), lactate dehydrogenase (LDH), and alkaline phosphatase (AKP) in serum were significantly higher and the inorganic phosphorus (IP) value was significantly lower in P-deficient compared with healthy sheep (P<0.01). Contents of α-globulin (α-GLB) and β-globulin (β-GLB) in serum from P-deficient sheep were markedly higher than those in healthy sheep (P<0.01). Serum γ-globulin (γ-GLB) was significantly lower than that in healthy sheep (P<0.01). Therefore, P deprivation in forage not only influenced the mineral content in animal tissue, but also severely disrupted blood parameters (physiology, biochemistry) in Wumeng sheep.

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Section: Discussionmentioning

confidence: 64%

Response of the Wumeng Sheep to Phosphorus Deprived Environment in the Southwest China

Zhao¹,

Min²,

Shen³

2021

Pol. J. Environ. Stud.

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“…The influence of P has been also shown to difference depend on the form of P. ( 47 , 48 ) P intake from the diet is classified as organic P from natural foods, or inorganic P from food additives. The rate of absorption of inorganic P is high than organic P, ( 49 , 50 ) and we have previously reported inorganic P has a stronger influence on vascular endothelium function than organic P in healthy men.…”

Section: Discussionmentioning

confidence: 99%

“…( 47 ) In addition, organic P is classified as animal-derived P and plant-derived P. In healthy subjects, the decrease in serum P levels have been reported to be lower after the intake of the milk, an animal product, than after the intake of the soymilk, a plant product. ( 48 ) This result may be because the bioavailability of animal-derived P is higher than that of plant-derived P in human. Further researches are needed to clarify differences in effect of dietary fiber and/or in production of IS depending on the P form.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary fiber on vascular calcification by repetitive diet-induced fluctuations in plasma phosphorus in early-stage chronic kidney disease rats

Tani

Tanaka

Takamiya

et al. 2020

J. Clin. Biochem. Nutr.

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Vascular calcification progresses under hyperphosphatemia, and represents a risk factor for cardiovascular disease in chronic kidney disease (CKD) patients. We recently indicated that phosphorus (P) fluctuations also exacerbated vascular calcification in early-stage CKD rats. Dietary fiber intake is reportedly associated with cardiovascular risk. This study investigated the effects of dietary fiber on vascular calcification by repeated P fluctuations in early-stage CKD rats. Unilateral nephrectomy rats were used as an early-stage CKD model. For 36 days, a P fluctuation (LH) group was fed low-P (0.02% P) and high-P (1.2% P) diets alternating every 2 days, and a P fluctuation with dietary fiber intake (LH + F) group was fed low-P and high-P diets containing dietary fiber alternating every 2 days. The effect on vascular calcification was measured calcium content. Effects on uremic toxin were measured levels of indoxyl sulfate (IS) and investigated gut microbiota. The LH + F group showed significantly reduced vessel calcium content compared to the LH group. Further, dietary fiber inhibited increases in blood levels of IS after intake of high-P diet, and decreased uremic toxin-producing intestinal bacteria. Dietary fiber may help suppress progression of vascular calcification due to repeated P fluctuations in early-stage CKD rats by decreasing uremic toxin-producing intestinal bacteria.

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“…A number of response criteria have been used to evaluate the phosphorus status of animals, including serum values of phosphorus, calcium, and alkaline phosphatase (Sakuma et al, 2018). A marked hypophosphatemia is also a good indicator of a severe phosphorus deficiency, even if serum contents of calcium are healthy.…”

Section: Discussionmentioning

confidence: 99%