Soybean β-Conglycinin Bromelain Hydrolysate Stimulates Cholecystokinin Secretion by Enteroendocrine STC-1 Cells to Suppress the Appetite of Rats under Meal-Feeding Conditions

Sufian, Md. Kaosar Niaz Bin; Hira, Tohru; Nakamori, Toshihiro; Furuta, Hitoshi; Asano, Kozo; Hara, Hiroshi

doi:10.1271/bbb.100765

Cited by 20 publications

(10 citation statements)

References 33 publications

(48 reference statements)

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“…We have previously demonstrated the CCK-mediated suppressive effect of a soybean ß-conglycinin hydrolysate on the food intake in rats. 17,23) Although the experimental conditions in this study were different from those in previous studies, the results shown in Fig. 2 demonstrate a similar or even slightly greater potency of the potato extract when compared to BconB in suppressing the food intake.…”

Section: Comparison Of Preloading Various Protein and Potatocontrasting

confidence: 51%

“…23) Both the potato extract and BconB treatment induced significant increases in the CCK concentration of the supernatant of STC-1 cells when compared to the control treatment (Fig. 5).…”

Section: Resultsmentioning

confidence: 86%

“…It consisted of 19.9% protein, 59.8% carbohydrate, 4.2% fibre, 0.2% fat, 11.8% ash and 4.1% water, this being analyzed by Japan Food Research Laboratories in Tokyo, Japan. The soybeanconglycinin bromelain hydrolysate (BconB) 23) was kindly provided by Fuji Oil Co. (Osaka, Japan), and the devazepide (L364,718) was from ML Laboratories (Liverpool, UK). All other materials were purchased from Wako (Osaka, Japan) unless otherwise specified.…”

Section: Methodsmentioning

confidence: 99%

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Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats

Chen

Hira

Nakajima

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Section: Comparison Of Preloading Various Protein and Potatocontrasting

confidence: 51%

“…23) Both the potato extract and BconB treatment induced significant increases in the CCK concentration of the supernatant of STC-1 cells when compared to the control treatment (Fig. 5).…”

Section: Resultsmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats

Chen

Hira

Nakajima

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…Soybean protein has beneficial effects on diabetes, obesity and serum lipids (12)(13)(14)(15)(16)(17)(18)(19)(20). Takahiro isolated the immunostimulating peptide His-Cys-Gln-Arg-Pro-Arg from a tryptic digest of soybean proteins, which has homology to tuftsin (Thr-Lys-Pro-Arg), is derived from a soybean glycinin subunit and can activate phagocytosis in human neutrophils (21).…”

Section: Popular Scientific Summarymentioning

confidence: 99%

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Zhang

Ying

et al. 2020

Food & Nutrition Research

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Background: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals. Objective: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats. Design: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized. Results: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation. Conclusions: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treatment and positive prognosis of burn patients.

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“…), soybean β‐conglycinin (Sufian et al . ), country beans (Sufian et al . ), and potato (Nakajima et al .…”

Section: Introductionmentioning

confidence: 99%

Antarctic Krill (Euphausia superba) Protein Hydrolysates Stimulate Cholecystokinin Release in STC-1 Cells and its Signaling Mechanism

Zhou

Liu

Zhao

et al. 2016

Journal of Food Processing and Preservation

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Antarctic krill (Euphausia superba) protein hydrolysates were produced by simulated gastrointestinal digestion (KPHSD) and alkaline proteinase hydrolysis (KPHAP), respectively. The effects of the hydrolysates on cholecystokinin (CCK) secretion and cAMP response element-binding protein (CREB) activation were tested in murine enteroendocrine cell line STC-1. Meanwhile, the signaling mechanism by which the hydrolysates induce CCK secretion was investigated by using inhibitors of signaling proteins. Results indicated that KPHSD and KPHAP both could significantly stimulate CCK secretion and CREB activation. The stimulating effects on CCK release showed a positive correlation with the relative content of peptides with molecular weight ranging from 1,000 to 3,000 Da, indicating this component may mainly account for the ability. The inhibitors on calcium-sensing receptor, PKA, Ca 21 /CaMKII, P 38 -MAPK, and an intracellular calcium chelator all inhibited krill protein hydrolysates-induced CCK secretion and CREB activation, indicating the involvement of the Ca 21 /CaM/CaMK, cAMP/PKA and MAPK pathways in the stimulation of CCK secretion. PRACTICAL APPLICATIONSAlthough Antarctic krill (Euphausia superba) has a large biomass and high-quality protein, its consumption by mankind, especially for its protein, is limited. In recent years, krill protein hydrolysates (KPHs) have attracted increasing attention due to their various health benefits. KPH is usually produced by using a proteolysis and centrifugation process, and the protein from muscle and internal tissue is reserved, but the cuticle is removed. The process can produce low-fluoride krill proteins (peptides) because the fluoride in krill is mainly located in the cuticle. The present study showed that KPHs produced by simulated gastrointestinal digestion and by alkaline proteinase hydrolysis were able to highly stimulate CCK secretion in intestinal endocrine STC-1 cells, indicating KPHs have potential application prospect as functional food ingredients for food intake-inhibitory effects.

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Soybean β-Conglycinin Bromelain Hydrolysate Stimulates Cholecystokinin Secretion by Enteroendocrine STC-1 Cells to Suppress the Appetite of Rats under Meal-Feeding Conditions

Cited by 20 publications

References 33 publications

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Antarctic Krill (Euphausia superba) Protein Hydrolysates Stimulate Cholecystokinin Release in STC-1 Cells and its Signaling Mechanism

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Soybean β-Conglycinin Bromelain Hydrolysate Stimulates Cholecystokinin Secretion by Enteroendocrine STC-1 Cells to Suppress the Appetite of Rats under Meal-Feeding Conditions

Cited by 20 publications

References 33 publications

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>&reg;</sup>) Involving Cholecystokinin Release in Rats

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>&reg;</sup>) Involving Cholecystokinin Release in Rats

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Antarctic Krill (Euphausia superba) Protein Hydrolysates Stimulate Cholecystokinin Release in STC-1 Cells and its Signaling Mechanism

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Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats