Soy Protein Suppresses Gene Expression of Acetyl-CoA Carboxylase Alpha from Promoter PI in Rat Liver

Hepatomegaly Induced byTrans-10,cis-12 Conjugated Linoleic Acid in Adult Hamsters Fed an Atherogenic Diet Is Not Associated with Steatosis

“…Thus, the potential involvement of this transcription factor pathway in ACC expression change should not be discarded. In Hepatomegaly without Steatosis Induced by CLA fact, several data exist in the literature suggesting its involvement in the regulation of liver lipogenesis induced by dietary components such as soy protein [38]. In the case of enzymes involved in fatty acid oxidation, the transcriptional factor controlling their expression is PPAR␣ [39 -41].…”

Effects of Lactobacillus Fermented Soymilk and Soy Yogurt on Hepatic Lipid Accumulation in Rats Fed a Cholesterol-Free Diet

“…The decrease in hepatic triglyceride content was caused by a reduction in liver weight and hepatic triglyceride level in the SY group (Tables 3 and 4). As reported in many studies, [1][2][3][4][5][6] it was assumed that the hepatic lipid-lowering effect was mainly due to the soy protein and isoflavone in the soymilk and okara. The protein and isoflavone contents were scarcely changed by fermentation.…”

“…Bioactive substances in soy foods, soy protein and isoflavone, have improving effects on plasma lipid levels [1][2][3] and have reducing effects on hepatic lipid accumulation by suppressing the gene expression of lipogenic enzymes and accelerating the gene expression of lipid degradation. [4][5][6] Tofu and soymilk are important protein sources for Asian populations. 7) Soymilk, rich in soy protein and isoflavones, is a food lowering plasma and hepatic lipid levels.…”

Soybean and Obesity

“…The ACC is the rate limiting enzyme in catalyzing the carboxylation of acetyl CoA to form malonyl CoA and is the main enzyme in the biosynthesis of long chain fatty acids. Aoki et al (2006) reported that SPI feeding decreased the hepatic contents of ACC alpha mRNA mainly by regulating PI promoter in rats. In addition, it was shown that soy protein decreased levels of TGC in rat liver also reducing the adipose tissue weight.…”