Soy protein supplementation does not cause lymphocytopenia in postmenopausal women

Soung, Do Y.; Patade, Anagha; Khalil, Dania A.; Lucas, Edralin A.; Devareddy, Latha; Greaves, Kathryn A.; Arjmandi, Bahram H.

doi:10.1186/1475-2891-5-12

Cited by 13 publications

(4 citation statements)

References 20 publications

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“…Lymphocytopenia has been shown in postmenopausal women who received a synthetic isoflavone for three years in a multicenter study [ 34 ]. However, a recent study found that isoflavone for one year did not alter lymphocyte counts in postmenopausal women [ 35 ]. Thus, the impact of HSCs and lymphopoiesis by plant components of isoflavoneor phytosterols remains to be solved.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Phytosterols Extracted from Diascorea alata on the Antioxidant Activity, Plasma Lipids, and Hematological Profiles in Taiwanese Menopausal Women

2017

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The efficacy of phytosterols extracted from Diascorea alata on antioxidant activities, plasma lipids and hematological profiles was assessed in postmenopausal women. Gas chromatography and mass spectrophotometry was employed to determine the steroid content of Taiwanese yam (Diascorea alata cv. Tainung No. 2). A two-center, randomized, double-blind, placebo-controlled clinical investigation on 50 postmenopausal women randomly assigned to two groups treated for 12 months with placebo or two sachets daily of Diascorea extracts containing 12 mg/dose was carried out. The main outcome measures were the plasma antioxidant activities, hematological profiles, and the concentrations of plasma lipids, including cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, very low density lipoprotein,, and apolipoprotein A1 and B. A one-way analysis of covariance (ANCOVA) test was performed to investigate the significance. Beta-sitosterol, stigmasterol, 22-23-dihydro-, and γ-sitosterol were major phytosterols determined from Diascorea extracts. At six months in those receiving Diascorea, there were significantly decreased leukocyte counts (p < 0.01) and improvement on antioxidant activity of malondialdehyde (p < 0.001). After 12 months’ treatment, elevations of hematocrit and mean corpuscular volume (p < 0.01) were noted in those receiving Diascorea. Moreover, the low dose Diascorea consumption in menopausal women for one year generally did not present positive effects on lipid profiles.

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Section: Discussionmentioning

confidence: 99%

The Effects of Phytosterols Extracted from Diascorea alata on the Antioxidant Activity, Plasma Lipids, and Hematological Profiles in Taiwanese Menopausal Women

2017

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“…Furthermore, Sridhar et al(2010) attributed the decrease in Hb to iron deficiency or to hemolytic or myelopathic conditions. The cause behind the increase in RDW% may be the increased immature RBCs or reticulocyte number (Soung et al, 2006).Free radicals can directly damage red blood cell membranes by peroxidation of membrane polyunsaturated fatty acids (Catala, 2009).It has been shown that thrombocytopenia in cancer patients is accompanied by anemia or leucopenia (Piatek and Akhtari, 2015).In the same concern, Akinbami et al (2013) reported that BC patients had lower MCV, MCH and MCHC values and higher RDW than control.…”

Section: Results In Tablementioning

confidence: 99%

Biochemical role of phytoestrogen (Chrysin) against N-methyl nitrosourea (NMU)- induced proliferative lesions in mammary glands of postmenopausal female rat

El-Kirsh

El-Wahab

Abd-Ellah

et al. 2015

Journal of Scientific Research in Science

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This study aimed to investigate the role of the phytoestrogen (chrysin) in the treatment or protection of NMU-induced preneoplastic lesions in mammary glands of postmenopausal female rats. Rats (n=105) were divided into seven groups (n=15/group); group1(negative control group).Groups 2&3 (positive control groups), rats were injected intraperitoneally (i.p.) with 4 doses of NMU (75 mg/kg b.w.,once/5days) before or after oral administration of glycofurol. Groups 4 &5(treatment groups),rats received 4 doses of NMU (75 mg/kg b.w., once/5days,i. p.), left for 6 weeks then followed by 3 doses, per week, of chrysin (125 or 250 mg/kg b.w., orally; p.o), respectively, for another 6 weeks. Groups 6 & 7(protective groups), rats received 3 doses, per week, of chrysin(125 or 250 mg/kg b.w.,p.o.), for 6 weeks then followed by 4 doses of NMU (75 mg/kg b.w., once/5days, i.p.) then left for another 6 weeks. The NMU injection caused significant decrease in PLT count, lymphocytes %, Hb, MCH, MCHC, E 2 , TAC levels as well as GST and CAT activities. The results also showed that NMU significantly elevated WBC count, granulocytes%, monocytes %, MCV, RDW%, CRP, CEA levels and arginase activity. Either treatment or protection with chrysin modulated the adverse effects of NMU and ameliorated the change in the biochemical parameters. The biochemical observations were also confirmed by histological studies. In conclusion, phytoestrogens may relieve the severity of postmenopausal pre-cancerous disorders, especially when consumed in high dose for a while before the incidence of lesions.

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“…These results were similar to the results of Ishimi et al (1999), who showed that an intake of isoflavones in ovariectomized rats improved haematological parameters [ 47 ]. Soung et al (2006) also observed that an intake of soy products in postmenopausal women had a beneficial effect on some haematological parameters [ 48 ] and that isoflavones may affect immune system functioning as a result of their receptors on lymphocytes [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Probiotic Soymilk Fortified with Omega-3 on Blood Glucose, Lipid Profile, Haematological and Oxidative Stress, and Inflammatory Parameters in Streptozotocin Nicotinamide-Induced Diabetic Rats

Sartang

Mazloomi

Tanideh

et al. 2015

Journal of Diabetes Research

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Objective. The aim of the present study was to evaluate the effects of probiotic soymilk fortified with omega-3 in diabetic rats. Methods. Soymilk (SM), fermented soymilk (FSM), and fermented soymilk fortified with omega-3 (FSM + omega-3) were prepared. Rats were randomly assigned to five groups of 13 animals per group. Diabetes was induced by a single injection of streptozotocin (STZ) 15 min after the intraperitoneal administration of nicotinamide (NA). Normal control (NC) and diabetic control (DC) rats received 1 mL/day of distilled water and three groups of diabetic rats were given 1 mL/day of SM, FSM, and FSM + omega-3 products by oral gavage for 28 days. Results. Three products significantly (P < 0.05) reduced blood glucose, total cholesterol (TC), triglyceride (TG), and malondialdehyde (MDA) concentrations compared to the DC group, with the maximum reduction seen in the FSM + omega-3 group. Body weight, red blood cells (RBC), haemoglobin (Hb), haematocrit, and superoxide dismutase (SOD) also significantly increased in the FSM + omega-3 group. In the FSM + omega-3 group, MDA level compared with the SM and FSM groups and high sensitivity C-reactive protein (hs-CRP) concentrations compared with the DC and FSM groups were significantly lower (P < 0.05). Conclusion. Fermented soymilk fortified with omega-3 may be beneficial in diabetes.

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Soy protein supplementation does not cause lymphocytopenia in postmenopausal women

Cited by 13 publications

References 20 publications

The Effects of Phytosterols Extracted from Diascorea alata on the Antioxidant Activity, Plasma Lipids, and Hematological Profiles in Taiwanese Menopausal Women

The Effects of Phytosterols Extracted from Diascorea alata on the Antioxidant Activity, Plasma Lipids, and Hematological Profiles in Taiwanese Menopausal Women

Biochemical role of phytoestrogen (Chrysin) against N-methyl nitrosourea (NMU)- induced proliferative lesions in mammary glands of postmenopausal female rat

The Effects of Probiotic Soymilk Fortified with Omega-3 on Blood Glucose, Lipid Profile, Haematological and Oxidative Stress, and Inflammatory Parameters in Streptozotocin Nicotinamide-Induced Diabetic Rats

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