Soy Protein Isolate Suppresses Lipodystrophy-induced Hepatic Lipid Accumulation in Model Mice

Nagao, Koji; Matsumoto, Akiko; Kai, Shunichi; Kayashima, Tomoko; Yanagita, Teruyoshi

doi:10.5650/jos.ess16145

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…However, the metabolome analysis showed that SPH reduced the hepatic glycocholic acid levels. Nagao et al ( 42 ) found that SPI reduced the lipodystrophy-induced hepatic cholesterol accumulation by inhibiting the expression of cholesterol synthesis genes. Unexpectedly, HMGCS1 and HMGCR were up-regulated by SPH infusion, which are the key enzymes that promote the de novo synthesis of cholesterol ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Determination of the Effects of Duodenal Infusion Soy Protein Hydrolysate on Hepatic Glucose and Lipid Metabolism in Pigs Through Multi-Omics Analysis

Ding

Zhu

et al. 2022

Front. Nutr.

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High animal protein intake increases hepatic lipid deposition and the risk of diabetes. However, the effects of high plant protein (HPP) intake on glycaemic responses and hepatic lipid metabolism in healthy people, as well as the underlying mechanisms, remain unclear. The current study explored the metabolomic and transcriptomic responses in the livers of pigs to assess the effects of HPP intake on host glucose and lipid metabolism. Sixteen pigs were infused with sterile saline or soy protein hydrolysate (SPH; 70 g/day) through a duodenal fistula twice daily during a 15 days experimental period. Hepatic metabolomic and transcriptomic analyses were performed, and the serum and hepatic biochemical parameters were measured. The results revealed that SPH infusion decreased serum glucose, hepatic triglyceride (TG), total cholesterol and low-density lipoprotein cholesterol levels, while it increased serum urea and eight hepatic amino acid levels (P < 0.05). Hepatic metabolomics displayed that SPH treatment produced seven different metabolites, four of which were related to lipid metabolism and one was related to glucose metabolism. In particular, lower (P < 0.05) glycocholic acid and glucose 1-phosphate levels and higher (P < 0.05) phosphatidylethanolamine (PE), arachidonic acid, prostaglandin F2α, l-carnitine and indole-3 acetic acid levels were observed following SPH infusion. A further metabolic pathway enrichment analysis found that these differential metabolites were mainly enriched in pathways related to lipid and glucose metabolism. Hepatic transcriptomics also demonstrated that multiple genes related to glucose and lipid metabolism were affected by SPH (P < 0.05). Together, SPH infusion reduced the hepatic TG levels by accelerating fatty acid β-oxidation and inhibiting TG synthesis. In addition, SPH infusion reduced the serum glucose levels by promoting hepatic glucose uptake and glycolysis. This study's result demonstrated that HPP intake regulated glycaemic responses and hepatic lipid metabolism in pigs without increasing the risk of hepatic lipid deposition and hyperglycaemia.

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Section: Discussionmentioning

confidence: 99%

Determination of the Effects of Duodenal Infusion Soy Protein Hydrolysate on Hepatic Glucose and Lipid Metabolism in Pigs Through Multi-Omics Analysis

Ding

Zhu

et al. 2022

Front. Nutr.

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“…Kunitz and Bowman–Birk are the most studied inhibitor families and are found in abundance in various leguminous plants (Oliveira et al., 2012 ). On one hand, they are considered as antinutritional components, which may negatively affect the nutritional quality and digestibility of soybean protein (Nagao et al., 2017 ). On the other hand, KTI and BBI are reported as potential chemopreventive agents; the important physiological roles and potential beneficial functions are also increasingly being recognized (Kennedy, 1998 ; Kobayashi et al., 2004 ; Zhou et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of freezing treatment of soybean on soymilk nutritional components, protein digestibility, and functional components

Cao

Tong

et al. 2021

Food Science & Nutrition

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Soymilk is a popular beverage in many countries, especially in Asian countries (Ono, 2008). It is rich in proteins, iron, unsaturated fatty acids, and niacin, but low in fat, carbohydrates, and calcium (Zhao et al., 2018). The soymilk benefits people who are lactose-intolerant or live in the regions where the supply of animal milk is inadequate. In addition, soymilk also contains some functional components such as Kunitz trypsin inhibitor (KTI), Bowman-Birk inhibitor (BBI), phytic acid, and tannins. Kunitz and Bowman-Birk are the most studied inhibitor families and are found in abundance in various leguminous plants (Oliveira et al., 2012).

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Soy Protein Isolate Suppresses Lipodystrophy-induced Hepatic Lipid Accumulation in Model Mice

Cited by 2 publications

References 39 publications

Determination of the Effects of Duodenal Infusion Soy Protein Hydrolysate on Hepatic Glucose and Lipid Metabolism in Pigs Through Multi-Omics Analysis

Determination of the Effects of Duodenal Infusion Soy Protein Hydrolysate on Hepatic Glucose and Lipid Metabolism in Pigs Through Multi-Omics Analysis

Effect of freezing treatment of soybean on soymilk nutritional components, protein digestibility, and functional components

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