Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo

Bitzer, Zachary T.; Wopperer, Amy; Chrisfield, Benjamin J.; Tao, Ling; Cooper, Timothy K.; Vanamala, Jairam; Elias, Ryan J.; Hayes, John E.; Lambert, Joshua D.

doi:10.1016/j.jnutbio.2016.11.012

Cited by 30 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have demonstrated that blocking the generation of reactive oxygen species (ROS) leads to decreased NLRP3 inflammasome activity and, subsequently, decreases IL-1β maturation and inflammation. Soybean peptides may also inhibit the expression of NLRP3 through modulating receptors, such as toll-like receptor (TLR)-4/nuclear factor (NF)κB (45).…”

Section: Discussionmentioning

confidence: 99%

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Zhang

Ying

et al. 2020

Food & Nutrition Research

View full text Add to dashboard Cite

Background: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals. Objective: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats. Design: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized. Results: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation. Conclusions: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treatment and positive prognosis of burn patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Zhang

Ying

et al. 2020

Food & Nutrition Research

View full text Add to dashboard Cite

show abstract

“…A prospective study in gout patients reported that the impact of plant purine on gout attacks was substantially smaller than purine from animal sources [37]. In addition, soy may prevent gout through the anti-inflammatory pathway, as a mouse study found that soy protein concentrates lower NLRP3 inflammasome and caspase-1 enzyme activity [48].…”

Section: High-soy Contents Within Taiwanese Vegetarian Dietary Pattermentioning

confidence: 99%

Vegetarian diet and risk of gout in two separate prospective cohort studies

et al. 2020

View full text Add to dashboard Cite

Backgrounds & aims: Plant-based diets may target multiple pathways in gout pathogenesis (uric acid reduction and anti-inflammation) while improving gout associated cardiometabolic comorbidities. We aim to prospectively examine the relationship between a vegetarian diet and gout, and to explore if this relationship is independent of hyperuricemia. Methods: We followed 4903 participants in the Tzu Chi Health Study (Cohort1, recruited in 2007e2009) and 9032 participants in the Tzu Chi Vegetarian Study (Cohort2, recruited in 2005) until end of 2014. Baseline serum uric acid was measured in Cohort1. Vegetarian status was assessed through a diet questionnaire that includes dietary habits and a food frequency questionnaire. Incidence of gout was ascertained by linkage to the National Health Insurance Database. Hazard Ratio of gout in vegetarians versus nonvegetarians was assessed by Cox regression, adjusted for age, sex, lifestyle and metabolic risk factors. Hyperuricemia was additionally adjusted in Cohort1. Results: In Cohort1, lacto-ovo vegetarians had the lowest uric acid concentration, followed by vegans, then nonvegetarians (men: 6.05, 6.19, 6.32 mg/dL, respectively; women: 4.92, 4.96, 5.11 mg/dL, respectively); 65 gout cases occurred in the 29,673 person-years of follow-up; vegetarians experienced a lower risk of gout (without adjustment for hyperuricemia: HR: 0.33; 95% CI: 0.14, 0.79; with adjustment for hyperuricemia: HR: 0.40; 95% CI: 0.17, 0.97). In Cohort2, 161 gout cases occurred in the 83,019 personyears follow-up, and vegetarians also experienced a lower risk of gout (HR: 0.61; 95% CI: 0.41, 0.88). Conclusion: Taiwanese vegetarian diet is associated with lower risk of gout. This protective association may be independent of baseline hyperuricemia.

show abstract

“…Colitis attenuation: Hirota et al, 24 Zaki et al, 25 Allen et al, 26 Itani et al, 27 Macia et al 75 Colitis/enteritis exacerbation: Bauer et al, 28 Bauer et al, 29 Liu et al, 37 Higashimori et al, 39 Ruiz et al, 68 Progatzky et al, 69 Bitzer et al, 70 Youm et al, 71 Zhao et al 74 Seo et al Suzuki et al, 52 Engler et al, 53 Ng et al 54 -H. pylori…”

Section: Nlrp3mentioning

confidence: 99%

“…68 Cholesterol consumption can trigger inflammasome-driven intestinal inflammation, which is dependent on the cholesterol-binding protein Niemann-Pick C1-like 1 and NF-kB activation by commensal microbiota. 69 Other metabolites can suppress the NLRP3 inflammasome, for instance soy protein 70 or the ketone body b-hydroxybutyrate, which characterizes caloric restrictive or ketogenic diets. 71 In addition, metabolic enzymes, such as hexokinase, can serve as PRRs and activate the NLRP3 inflammasome upon metabolic signals pertaining to glycolysis or the tricarboxylic acid pathway.…”

Section: Canonical Inflammasomes In Gastrointestinal Physiology Nlrp3mentioning

confidence: 99%

Inflammasomes and intestinal inflammation

et al. 2017

View full text Add to dashboard Cite

The inflammasome is a cytosolic multi-protein innate immune rheostat, sensing a variety of endogenous and environmental stimuli, and regulating homeostasis or damage control. In the gastrointestinal tract, inflammasomes orchestrate immune tolerance to microbial and potentially food-related signals or drive the initiation of inflammatory responses to invading pathogens. When inadequately regulated, intestinal inflammasome activation leads to a perpetuated inflammatory response leading to immune pathology and tissue damage. In this review, we present the main features of the predominant types of inflammasomes participating in intestinal homeostasis and inflammation. We then discuss current controversies and open questions related to their functions and implications in disease, highlighting how pathological inflammasome over-activation or impaired function impact gut homeostasis, the microbiome ecosystem, and the propensity to develop gut-associated diseases. Collectively, understanding of the molecular basis of intestinal inflammasome signaling may be translated into clinical manipulation of this fundamental pathway as a potential immune modulatory therapeutic intervention.

show abstract

Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo

Cited by 30 publications

References 39 publications

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors

Vegetarian diet and risk of gout in two separate prospective cohort studies

Inflammasomes and intestinal inflammation

Contact Info

Product

Resources

About