Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials

Taku, Keisei; Umegaki, Keizo; Sato, Yoko; Taki, Yuko; Endoh, Kaori; Watanabe, Shaw

doi:10.1093/ajcn/85.4.1148

Cited by 315 publications

(198 citation statements)

References 26 publications

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“…This effect appears to be due to the replacement of animal proteins with soy protein, and not specifically due to the isoflavone content (136,138). However, certain subgroups may observe improvements in HDL cholesterol (+13%) with isoflavone supplementation, as was shown in postmenopausal women with a particular ERb polymorphism (139).…”

Section: Isoflavonesmentioning

confidence: 90%

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Millar

Duclos

Blesso

2017

Advances in Nutrition

141

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Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. In certain inflammatory disease states, however, HDL particles may become dysfunctional and proatherogenic. Flavonoids show the potential to improve HDL function through their welldocumented effects on cellular antioxidant status and inflammation. The aim of this review is to summarize the basic science and clinical research examining the effects of dietary flavonoids on RCT and HDL function. Based on preclinical studies that used cell culture and rodent models, it appears that many flavonoids (e.g., anthocyanidins, flavonols, and flavone subclasses) influence RCT and HDL function beyond simple HDL cholesterol concentration by regulating cellular cholesterol efflux from macrophages and hepatic paraoxonase 1 expression and activity. In clinical studies, dietary anthocyanin intake is associated with beneficial changes in serum biomarkers related to HDL function in a variety of human populations (e.g., in those who are hyperlipidemic, hypertensive, or diabetic), including increased HDL cholesterol concentration, as well as HDL antioxidant and cholesterol efflux capacities. However, clinical research on HDL functionality is lacking for some flavonoid subclasses (e.g., flavanols, flavones, flavanones, and isoflavones). Although there has been a tremendous effort to develop HDL-targeted drug therapies, more research is warranted on how the intake of foods or specific nutrients affects HDL function. Adv Nutr 2017;8:226-39.

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Section: Isoflavonesmentioning

confidence: 90%

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Millar

Duclos

Blesso

2017

Advances in Nutrition

141

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“…In particular, surprisingly, the health benefits provided by lupin polyphenols have been rarely investigated, although these phytochemicals are main bioactive food components, providing numerous health benefits. In particular, they are strong antioxidants, useful for preventing lipid oxidation and atherosclerosis formation, and efficient ACE-inhibitors (Sato, Mukai, Yamate, Kato, Kurasaki, Hatai, et al, 2008;Shahidi & Chandrasekara, 2013;Taku, Umegaki, Sato, Taki, Endoh, & Watanabe, 2007). As already indicated in the introduction, the two most abundant polyphenols in lupin are apigenin-6,8-di-C-β-glucopyranoside H and apigenin 7-O-β-apiofuranosyl-6,8-di-C-β-glucopyranoside I.…”

mentioning

confidence: 93%

The health benefits of sweet lupin seed flours and isolated proteins

Arnoldi

Boschin

Zanoni

2015

Journal of Functional Foods

118

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Abstract.The interest for lupin is continuously growing: one driving force are the numerous studies showing it provides useful health benefits. This review discusses available literature in the area of dyslipidaemia, diabetes, and hypertension prevention, providing hints on the mechanism of action.The addition of lupin protein to the diet of different models of hypercholesterolaemia, such as rat, rabbit, hamster and pig, induce decreases of total and non-HDL cholesterol. The clinical investigations on the cholesterol lowering activity provided controversial results. Those involving hypercholesterolaemic subjects and based on improved lupin foods gave statistically significant total and/or LDL-cholesterol reductions: both protein and fibre are relevant. The moderate hypotensive activity observed in some studies is probably linked to digestion-released ACE-inhibitory peptides.The hypoglycaemic activity, observed in post-prandial studies, is due to gamma-conglutin, a specific protein fraction. All this information suggests that lupin seeds may become a source of ingredients of innovative functional foods.Abbreviations: ACE, angiotensin converting enzyme; Akt, protein kinase B; DBP; diastolic blood pressure; GSK3, glycogen synthase kinase 3; HDL-C, high-density-lipoprotein cholesterol;HMGCoA, 3-hydroxy-3-methylglutaryl coenzyme A; LDL-C, low-density-lipoprotein cholesterol; NL-LUP, narrow-leaf lupin protein isolate; NPS, non-starch polysaccharides; PI3K, phosphatidylinositol 3'-kinase; SBP, systolic blood pressure; SCAP, SREBP-cleavage activating protein; SREBP, sterol regulatory element binding protein; TAG, triacylglycerides; TOC, tocopherol; W-LUP, white lupin protein isolate.

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“…A recent systematic review identified 9 clinical trials examining the effects of increased dietary soy and 9 additional trials examining the efficacy of soy extracts, and concluded that neither was effective for menopausal symptoms. 29 A recent review of 11 trials found that soy was effective for lowering total and lowdensity lipoprotein (LDL) cholesterol by 4-5%, 30 a small effect comparable to that observed in studies of garlic.…”

mentioning

confidence: 99%

Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation

2008

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Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials

Cited by 315 publications

References 26 publications

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL function

The health benefits of sweet lupin seed flours and isolated proteins

Herbal Medicine in the United States: Review of Efficacy, Safety, and Regulation

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