Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice

Sakai, Tohru; Furoku, Sakina; Nakamoto, Mariko; Shuto, Emi; Hosaka, Toshio; Nishioka, Yasuhiko; Sone, Saburo

doi:10.1271/bbb.100710

Cited by 21 publications

(20 citation statements)

References 19 publications

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“…Similar to EGCG, green tea polyphenols at doses <0.5 % inhibited DSS-induced colitis, whereas doses of 0.5-1 % fortified colitis symptoms and mortality [59][60][61]. Another example is represented by genistein that a dose of 20 mg/kg reduced survival relative to the non-treated DSS-CTL group whereas lower concentrations (2 and 10 mg/kg) were more beneficial [62]. Evaluation of the preventive and therapeutic effects of DAPP showed a significant improvement of the DSS-induced clinical manifestations, as evidenced by the alleviation of body weight loss, diarrhoea and faecal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease

et al. 2016

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Diets rich in fruits and vegetables may reduce oxidative stress (OxS) and inflammation via several mechanisms. These beneficial effects may be due to their high polyphenol content. The aims of the present study are to evaluate the preventive and therapeutic aspects of polyphenols in dried apple peel powder (DAPP) on intestinal inflammation while elucidating the underlying mechanisms and clinical benefits. Induction of intestinal inflammation in mice was performed by oral administration of the inflammatory agent dextran sulfate sodium (DSS) at 2.5% for 10 days. Physiological and supraphysiological doses of DAPP (200 and 400 mg/kg/day respectively) were administered by gavage for 10 days pre- and post-DSS treatment. DSS-mediated inflammation caused weight loss, shortening of the colon, dystrophic detachment of the epithelium, and infiltration of mono- and poly-morphonuclear cells in the colon. DSS induced an increase in lipid peroxidation, a down-regulation of antioxidant enzymes, an augmented expression of myeloperoxidase (MPO) and cyclooxygenase-2 (COX-2), an elevated production of prostaglandin E2 (PGE2) and a shift in mucosa-associated microbial composition. However, DAPP normalized most of these abnormalities in preventive or therapeutic situations in addition to lowering inflammatory cytokines while stimulating antioxidant transcription factors and modulating other potential healing pathways. The supraphysiological dose of DAPP in therapeutic situations also improved mitochondrial dysfunction. Relative abundance of Peptostreptococcaceae and Enterobacteriaceae bacteria was slightly decreased in DAPP-treated mice. In conclusion, DAPP exhibits powerful antioxidant and anti-inflammatory action in the intestine and is associated with the regulation of cellular signalling pathways and changes in microbiota composition. Evaluation of preventive and therapeutic effects of DAPP may be clinically feasible in individuals with intestinal inflammatory bowel diseases.

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Section: Discussionmentioning

confidence: 99%

Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease

et al. 2016

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“…A number of studies have reported that the main bioactive compounds in soy sauce, including genistein and daidzein, effectively reduce the levels of TNF-a, an important inflammatory mediator, elevated by IBD in experimental rodent models. [46][47][48] Genistein also fails to decrease T-cell proliferation and reduces the production of IL-1b and IL-6 in lipopolysaccharide (LPS)-treated mice. 49 Sesamin and sesamolin have been shown to inhibit TNF-a, IL-1b, and IL-6 activity in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Anti-Colitic Effects of Kanjangs (Fermented Soy Sauce and Sesame Sauce) in Dextran Sulfate Sodium-Induced Colitis in Mice

Song

Choi²,

Seo³

et al. 2014

Journal of Medicinal Food

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This study was conducted to investigate the preventive effects of different kanjangs (Korean soy sauces), including acid-hydrolyzed soy sauce (AHSS), fermented soy sauce (FSS), and fermented sesame sauce (FSeS), on 2% dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL/6J mice. The fermented sauces, particularly FSeS, significantly suppressed DSS-induced body weight loss, increased colon length, and decreased colon weight/length ratios. Histological observations suggested that the fermented sauces prevented edema, mucosal damage, and the loss of crypts induced by DSS compared to the control mice and animals fed AHSS. FSeS and FSS decreased the serum levels of tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin (IL)-6, and IL-17α. mRNA expression of these cytokines as well as that of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in colon mucosa was also inhibited by the two sauces. Our results suggest that fermented sauces, especially FSeS, exert an anticolitic effect partially by reducing the serum levels of proinflammatory cytokines and inhibiting the mRNA expression of these factors in the colon tissue of mice treated with DSS. However, AHSS did not protect against DSS-induced colitis. In addition, low-dose treatment (4 mL/kg) with the fermented sauces resulted in greater anticolitic effects than consumption of a high quantity (8 mL/kg) of the sauces.

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“…Honokiol inhibited CIA progression by reducing the production of pro-inflammatory cytokines, the expression of MMPs, and oxidative stress. Also, as explained by Morimoto et al [83], natural soy isoflavones such as genistein and daidzein present as inactive β-glycosides and are converted in vivo to the active bioavailable aglycone form by enterobacteria. Isoflavones exist primarily as glucoside forms and rarely as aglycone forms.…”

Section: Flavonoids and Related Compoundsmentioning

confidence: 99%

“…Chao et al [80] reported that honokiol at 10 µg/ml inhibited LPS-induced TNF-α secretion in macrophages without affecting the activity of the TNF-α converting enzyme. A recently published note [83] argues that soy isoflavones perpetuate DSS-induced ulcerative colitis in mice instead of ameliorating it. With the aid of confocal microscope analysis, the authors observed that honokiol inhibited phosphorylation and membrane translocation of protein kinase (PK)C-α as well as NF-κB activation.…”

Section: Flavonoids and Related Compoundsmentioning

confidence: 99%

“…Recently [81], it has been reported that the oral administration of honokiol (10 or 20 mg/kg once per day from days 25 to 45) inhibited the progression and severity of CIA, reducing clinical arthritis scores and paw swelling. The effects of soy isoflavones in different human populations may vary as only 30-50% of humans can metabolize daidzein to equol [83]. Isoflavones are a class of flavonoids abundantly present in Leguminosae plants such as soybeans, which have been consumed in Asian countries for centuries.…”

Section: Flavonoids and Related Compoundsmentioning

confidence: 99%

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Anti-Inflammatory Agents from Plants: Progress and Potential

Recio

Andújar

Rı́os

2012

CMC

156

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The identification of substances that can promote the resolution of inflammation in a way that is homeostatic, modulatory, efficient, and well-tolerated by the body is of fundamental importance. Traditional medicines have long provided front-line pharmacotherapy for many millions of people worldwide. Medicinal extracts are a rich source of therapeutic leads for the pharmaceutical industry. The use of medicinal plant therapies to treat chronic illness, including rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), is thus widespread and on the rise.The aim of this review is to present recent progress in clinical anti-inflammatory studies of plant extracts and compound leads such as green tea polyphenols, curcumin, resveratrol, boswellic acid, and cucurbitacins, among others, against chronic inflammatory diseases, mainly RA and IBD. In this context, the present paper also highlights the most promising experimental data on those plant extracts and pure compounds active in animal models of the aforementioned diseases.

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Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice

Cited by 21 publications

References 19 publications

Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease

Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease

Anti-Colitic Effects of Kanjangs (Fermented Soy Sauce and Sesame Sauce) in Dextran Sulfate Sodium-Induced Colitis in Mice

Anti-Inflammatory Agents from Plants: Progress and Potential

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