Soy hull dietary fiber alleviates inflammation in BALB/C mice by modulating the gut microbiota and suppressing the TLR-4/NF-κB signaling pathway

Yang, Ling; Lin, Qian; Lin, Han; Wang, Ziyi; Luo, Mingshuo; Kang, Wanrong; Liu, Jie; Ma, Tao; Li, He

doi:10.1039/d0fo01102a

Cited by 38 publications

(27 citation statements)

References 53 publications

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“…Thereby, the SBP may relieve in ammation by increasing the production of anti-in ammatory cytokine IL-10. Likewise, previous studies also found that higher intake of dietary ber was closely related to decreased severity of in ammation, in contrast, dietary ber deprivation resulted in in ammation and increased pathogen susceptibility [43][44][45]. The positive effects of dietary ber on in ammation observed in this study may be correlated to the changed gut microbiota and their by-products induced by the two sources of ber supplementation [46].…”

Section: Discussionsupporting

confidence: 78%

Impact of sugar beet pulp and wheat bran on serum biochemical profile, inflammatory responses and gut microbiota in sows during late gestation and lactation

Shang

Liu

et al. 2020

Preprint

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Background: Sows are frequently subjected to various stresses during late gestation and lactation, which trigger inflammatory response and metabolic disorders. Dietary fiber can influence animal health by modulating gut microbiota and their by-products, with the effects depending upon the source of the dietary fiber. This study aimed to evaluate the impacts of different fiber sources on body condition, serum biochemical parameters, inflammatory responses and fecal microbiota in sows from late gestation to lactation.Methods: Forty-five multiparous sows (Yorkshire × Landrace; 3-6 parity) were assigned to 1 of 3 dietary treatments from d 85 of gestation to the end of lactation (d 21 post-farrowing): a control diet (CON, a corn-soybean meal diet), a sugar beet pulp diet (SBP, 20% SBP during gestation and 10% SBP during lactation), and a wheat bran diet (WB, 30% WB during gestation and 15% WB during lactation).Results: Compared with CON, supplementation of SBP decreased (P < 0.05) lactation BW loss, reduced (P < 0.05) serum concentration of total cholesterol, non-esterified fatty acids, interleukin-6 and tumor necrosis factor-α, and increased (P < 0.05) fecal water content on d 110 of gestation and d 21 of lactation, while supplementation of WB reduced (P < 0.05) serum concentration of total cholesterol on d 110 of gestation, increased (P < 0.05) fecal water content and decreased (P < 0.05) serum interleukin-6 concentration on d 110 of gestation and d 21 of lactation. In addition, sows fed SBP had lower (P < 0.01) abundance of Clostridium_sensu_stricto_1 and Terrisporobacter than those fed CON, but had greater (P < 0.05) abundance of Christensenellaceae_R-7_group and Ruminococcaceae_UCG-002 than those fed the other two diets on d 110 of gestation. On d 21 of lactation, supplementation of SBP decreased (P < 0.05) the abundance of Firmicutes and Lactobacillus, but enriched (P < 0.05) the abundance of Christensenellaceae_R-7_group, Prevotellaceae_NK3B31_group, Ruminococcaceae_UCG-002, Prevotellaceae_UCG_001 and unclassified_f__Lachnospiraceae compared with WB. Compared with CON, sows fed SBP had greater (P < 0.05) fecal concentrations of acetate, butyrate and total SCFAs during gestation and lactation, while sows fed WB only had greater (P < 0.05) fecal concentration of butyrate during lactation.Conclusions: Supplementation of dietary fiber during late gestation and lactation could improve sow metabolism and gut health, and SBP was more effective than WB.

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Section: Discussionsupporting

confidence: 78%

Impact of sugar beet pulp and wheat bran on serum biochemical profile, inflammatory responses and gut microbiota in sows during late gestation and lactation

Shang

Liu

et al. 2020

Preprint

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show abstract

“…Thereby, the SBP may relieve inflammation by increasing the production of antiinflammatory cytokine IL-10. Likewise, previous studies also found that higher intake of dietary fiber was closely related to decreased severity of inflammation, in contrast, dietary fiber deprivation resulted in inflammation and increased pathogen susceptibility [44][45][46]. The positive effects of dietary fiber on inflammation observed in this study may be correlated to the changed gut microbiota and their by-products induced by the two sources of fiber supplementation [47].…”

Section: Discussionsupporting

confidence: 78%

Impact of sugar beet pulp and wheat bran on serum biochemical profile, inflammatory responses and gut microbiota in sows during late gestation and lactation

Shang

Liu

et al. 2021

J Animal Sci Biotechnol

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Background Sows are frequently subjected to various stresses during late gestation and lactation, which trigger inflammatory response and metabolic disorders. Dietary fiber can influence animal health by modulating gut microbiota and their by-products, with the effects depending upon the source of the dietary fiber. This study aimed to evaluate the impacts of different fiber sources on body condition, serum biochemical parameters, inflammatory responses and fecal microbiota in sows from late gestation to lactation. Methods Forty-five multiparous sows (Yorkshire × Landrace; 3–6 parity) were assigned to 1 of 3 dietary treatments from d 85 of gestation to the end of lactation (d 21 post-farrowing): a control diet (CON, a corn-soybean meal diet), a sugar beet pulp diet (SBP, 20% SBP during gestation and 10% SBP during lactation), and a wheat bran diet (WB, 30% WB during gestation and 15% WB during lactation). Results Compared with CON, supplementation of SBP decreased (P < 0.05) lactation BW loss, reduced (P < 0.05) serum concentration of total cholesterol, non-esterified fatty acids, interleukin-6 and tumor necrosis factor-α, and increased (P < 0.05) fecal water content on d 110 of gestation and d 21 of lactation, while supplementation of WB reduced (P < 0.05) serum concentration of total cholesterol on d 110 of gestation, increased (P < 0.05) fecal water content and decreased (P < 0.05) serum interleukin-6 concentration on d 110 of gestation and d 21 of lactation. In addition, sows fed SBP had lower (P < 0.01) abundance of Clostridium_sensu_stricto_1 and Terrisporobacter than those fed CON, but had greater (P < 0.05) abundance of Christensenellaceae_R-7_group and Ruminococcaceae_UCG-002 than those fed the other two diets on d 110 of gestation. On d 21 of lactation, supplementation of SBP decreased (P < 0.05) the abundance of Firmicutes and Lactobacillus, but enriched (P < 0.05) the abundance of Christensenellaceae_R-7_group, Prevotellaceae_NK3B31_group, Ruminococcaceae_UCG-002, Prevotellaceae_UCG_001 and unclassified_f__Lachnospiraceae compared with WB. Compared with CON, sows fed SBP had greater (P < 0.05) fecal concentrations of acetate, butyrate and total SCFAs during gestation and lactation, while sows fed WB only had greater (P < 0.05) fecal concentration of butyrate during lactation. Conclusions Supplementation of dietary fiber during late gestation and lactation could improve sow metabolism and gut health, and SBP was more effective than WB.

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“…Soy milk increases the ratio of Firmicutes and Bacteriodetes due to an increase in Lactobacillus species, and soy milk with fiber greatly decreases the ratio of Allobaculum and Parabacteroides species, related to inflammation in rodents [39]. Soy dietary fiber intake exhibits a positive association with the relative abundance of Lactobacillus, Ruminococcus, Bifidobacteriales, and Flavonifractor at the genus level, which is linked to suppressing tolllike receptor (TLR)-4 → NF-kB signaling pathways in laboratory animals [40,41]. Gut microbiota uses soy dietary fiber as an energy source since it is a soluble dietary fiber.…”

Section: Components Of Soybeans That Function As Prebiotics To Reduce the Risk Of Metabolic Diseases 41 Dietary Fibermentioning

confidence: 99%

“…Isoflavone aglycones can directly reduce intracellular tau-related neurofibrillary tangles and extracellular amyloid-β deposition in the brain, especially the hippocampus, preventing and alleviating neuronal cell death in both in vitro and in vivo studies [20,65]. Dietary fiber and isoflavones in chungkookjang also modulate the gut microbiome to reduce neurotoxin production and elevate neuroprotection components such as butyrate, short-chain fatty acids (SCFA) [4,41]. These components produced by the gut microbiota may also alter systemic inflammation and insulin resistance to influence neuronal cell survival and death by the gut-microbiome-liver-brain axis.…”

Section: Chungkookjang Effects On Systemic and Neuroinflammation And Neuronal Survivalmentioning

confidence: 99%

γ-PGA-Rich Chungkookjang, Short-Term Fermented Soybeans: Prevents Memory Impairment by Modulating Brain Insulin Sensitivity, Neuro-Inflammation, and the Gut–Microbiome–Brain Axis

Jeong¹,

Ryu²,

Yang³

et al. 2021

Foods

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Fermented soybean paste is an indigenous food for use in cooking in East and Southeast Asia. Korea developed and used its traditional fermented foods two thousand years ago. Chungkookjang has unique characteristics such as short-term fermentation (24–72 h) without salt, and fermentation mostly with Bacilli. Traditionally fermented chungkookjang (TFC) is whole cooked soybeans that are fermented predominantly by Bacillus species. However, Bacillus species are different in the environment according to the regions and seasons due to the specific bacteria. Bacillus species differently contribute to the bioactive components of chungkookjang, resulting in different functionalities. In this review, we evaluated the production process of poly-γ-glutamic acid (γ-PGA)-rich chungkookjang fermented with specific Bacillus species and their effects on memory function through the modulation of brain insulin resistance, neuroinflammation, and the gut–microbiome–brain axis. Bacillus species were isolated from the TFC made in Sunchang, Korea, and they included Bacillus (B.) subtilis, B. licheniformis, and B. amyloliquefaciens. Chungkookjang contains isoflavone aglycans, peptides, dietary fiber, γ-PGA, and Bacillus species. Chungkookjangs made with B. licheniformis and B. amyloliquefaciens have higher contents of γ-PGA, and they are more effective for improving glucose metabolism and memory function. Chungkookjang has better efficacy for reducing inflammation and oxidative stress than other fermented soy foods. Insulin sensitivity is improved, not only in systemic organs such as the liver and adipose tissues, but also in the brain. Chungkookjang intake prevents and alleviates memory impairment induced by Alzheimer’s disease and cerebral ischemia. This review suggests that the intake of chungkookjang (20–30 g/day) rich in γ-PGA acts as a synbiotic in humans and promotes memory function by suppressing brain insulin resistance and neuroinflammation and by modulating the gut–microbiome–brain axis.

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Soy hull dietary fiber alleviates inflammation in BALB/C mice by modulating the gut microbiota and suppressing the TLR-4/NF-κB signaling pathway

Abstract: Soy hull DF delayed glucose diffusion and absorption of bile acid. Soy hull DF alleviates inflammation in mice through suppressing TLR-4/NF-κB signaling pathway. Soy hull DF ameliorates the colitis induced decrease in gut microbiota species richness.

Cited by 38 publications

References 53 publications

Impact of sugar beet pulp and wheat bran on serum biochemical profile, inflammatory responses and gut microbiota in sows during late gestation and lactation

Impact of sugar beet pulp and wheat bran on serum biochemical profile, inflammatory responses and gut microbiota in sows during late gestation and lactation

Impact of sugar beet pulp and wheat bran on serum biochemical profile, inflammatory responses and gut microbiota in sows during late gestation and lactation

γ-PGA-Rich Chungkookjang, Short-Term Fermented Soybeans: Prevents Memory Impairment by Modulating Brain Insulin Sensitivity, Neuro-Inflammation, and the Gut–Microbiome–Brain Axis

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