Soy consumption for reduction of menopausal symptoms

Kurzer, Mindy S.

doi:10.1007/s10787-008-8021-z

Cited by 40 publications

(27 citation statements)

References 32 publications

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“…More recently, evidence suggests that isoflavones may not only have estrogenic effects, but are also antiestrogenic in some mammalian tissues [4]. The preferential binding of isoflavones to estrogen receptor β suggests that they may act as SERMs (selective estrogen receptor modulators) [5]. The majority of soy diet and bone research has been conducted in adult human participants and experimental rodents.…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat

Zhang

Lazarenko

et al. 2012

PLoS ONE

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BackgroundPrevious reports suggest that beneficial effects of soy on bone quality are due to the estrogenic actions of isoflavone phytochemicals associated with the protein. However, mechanistic studies comparing the effects of soy diet and estrogens on bone, particularly in rapidly growing animals are lacking.Methodology and Principal FindingsWe studied the effects of short term feeding of soy protein isolate (SPI) on bone in comparison to the effects of 17β-estradiol (E2) in pre-pubertal rats. Female rats were weaned to one of 4 treatments: 1) a control casein-based diet (CAS); 2) CAS with subcutaneous E2 (10 µg/kg/d) (CAS+E2); 3) a SPI-containing diet (SPI); or 4) SPI with subcutaneous E2 (SPI) or SPI with 10 µg/kg/d E2 (SPI+E2) for 14 days beginning on postnatal day 20. SPI increased while E2 decreased bone turnover compared to CAS. In contrast, both treatments decreased serum sclerostin levels. Microarray analysis of RNA isolated from bone revealed 652 genes regulated by SPI, 491 genes regulated by E2, and 266 genes regulated by both SPI diet and E2 compared to CAS. The expression of caveolin-1, a protein localized in the cell membrane, was down-regulated (p<0.05) in rats fed SPI, but not by E2 compared to rats fed casein. Down-regulation of caveolin-1 by SPI was associated with increased BMP2, Smad and Runx2 expression in bone and osteoblasts (p<0.05).Conclusions/SignificanceThese results suggest SPI and E2 have different effects on bone turnover prior to puberty. Approximately half of the genes are regulated in the same direction by E2 or SPI, but in combination, SPI blocks the estrogen effects and returns the profile towards control levels. In addition, there are E2 specific and SPI-specific gene changes related to regulation of bone formation.

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Section: Introductionmentioning

confidence: 99%

Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat

Zhang

Lazarenko

et al. 2012

PLoS ONE

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“…Indeed, in randomized clinical trials, genistein has been shown to reduce hot flashes by 50% [1] . Epidemiological and case-controlled studies in Asian women have reported a negative correlation between breast cancer and the intake of soy products [2,3] .…”

Section: Introductionmentioning

confidence: 99%

Genistein in the Presence of 17β-Estradiol Inhibits Proliferation of ERβ Breast Cancer Cells

Rajah

Drews

et al. 2009

Pharmacology

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Background/Aim:Genistein, a soy component, has been shown to have a biphasic proliferative effect in breast cancer cells, inhibiting in vitro cell proliferation at high concentrations (>10 μmol/l), while stimulating cell proliferation at lower concentrations (<10 μmol/l). However, epidemiological studies have shown an inverse correlation between the intake of genistein and the incidence of breast cancer. One of the possible reasons for this discrepancy could be the differing status of the estrogen receptor (ERα and/or ERβ). Genistein selectively binds to ERβ with strong affinity and thereby could be a potential chemotherapeutic agent against breast cancer of the ERα-negative and ERβ-positive type. Therefore, the objective of the present study was to determine whether the proliferative effects of genistein were caused by its activity as a selective ERβ agonist or merely as an antiestrogen. Method: This study was carried out in MDA-MB-231 (ERβ) and T47D (ERα and ERβ) human breast cancer cells. Cell proliferation was determined by the MTT (3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide) assay. The cells were grown in estrogen-starved media and exposed to genistein at different concentrations for 72 h, either in the presence or absence of 17β-estradiol. Results: A significant decrease in cell proliferation was seen in MDA-MB-231 cells at low concentrations of genistein in the presence of 17β-estradiol, as compared to genistein alone. In T47D cells, which are known to have a predominance of ERα over ERβ, genistein showed a biphasic cell proliferative response both in the presence and absence of 17β-estradiol. Conclusions:Our results suggest that in cells with a predominance of ERα, genistein acts as an agonist to ERα, and in cells with ERβ alone, genistein most likely acts as an antiestrogen. Our results also suggest that genistein could be useful as a chemotherapeutic agent in premenopausal women with breast cancer of the ERα-negative and ERβ-positive type.

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“…30 So, the current authors' dietary approach is primarily based on epidemiologic data: Asian women on a traditional diet average a 10%-20% incidence of vasomotor symptoms, compared to the 70%-80% incidence in Western countries. 31 There are also suggestions underscoring the difference between whole foods (and whole herbs) versus supplements. For instance, soy is deemed to have heart-healthy benefits, which are often attributed to soy isoflavones.…”

Section: A Basic Approach To Night Sweatsmentioning

confidence: 99%

Night Sweats in Perimenopause and Beyond

AbascalKathy

Yarnell

2013

Alternative and Complementary Therapies

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Herbal treatments can help quiet perimenopausal symptoms, such as night sweats, successfully. However, given the prevalence of xenoestrogens and their increased effects in menopausal women, treatment of night sweats also should include a nutritional component and adaptogens to help women cope with the hormonal changes that are experienced. Actaea racemosa (also known as Cimicifuga racemosa, black cohosh) root, Angelica sinensis (dong quai) root, Verbena spp. (vervain) herb, Melissa officinalis (lemon balm) herb, Salvia spp. (sage) herb, Lycopus spp. (bugleweed) herb, Schisandra chinensis (schisandra) berry, Withania somnifera (ashwagandha) root, Panax quinquefolius (American ginseng) root, and Astragalus membranaceus (astragalus) root all have roles to play in the treatment of perimenopausal night sweats.

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Soy consumption for reduction of menopausal symptoms

Cited by 40 publications

References 32 publications

Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat

Differential Effects of Short Term Feeding of a Soy Protein Isolate Diet and Estrogen Treatment on Bone in the Pre-Pubertal Rat

Genistein in the Presence of 17β-Estradiol Inhibits Proliferation of ERβ Breast Cancer Cells

Night Sweats in Perimenopause and Beyond

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