Soy‐based formulas and phyto‐oestrogens: a safety profile

Miniello, VL; Moro, Giorgio; Tarantino, Matteo; M, Natile; Granieri, Letizia; Armenio, L

doi:10.1111/j.1651-2227.2003.tb00655.x

Cited by 34 publications

(18 citation statements)

References 104 publications

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“…There is a paucity of data on endocrine effects of soy phytochemicals such as genistein and daidzein during infancy, the most sensitive period of life for the induction of toxicity. The safety of isoflavones in infant formulas has been questioned recently owing to reports of possible hormonal effects (Miniello et al , 2003). Closer studies are necessary both in experimental animals and human populations exposed to phytoestrogen containing products, and particularly to soy-based infant formulas, as the estrogenic activity of genistein at high doses has been shown to be associated with decreased fertility and increased sexual dysfunction in experimental animals (You et al , 2002).…”

Section: Possible Deleterious Impacts Of Utilizing Phenolic Compoundsmentioning

confidence: 99%

Toxicological aspects of the use of phenolic compounds in disease prevention

Kyseľová¹

2011

Interdisciplinary Toxicology

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Toxicological aspects of the use of phenolic compounds in disease preventionThe consumption of a diet low in fat and enhanced by fruits and vegetables, especially rich in phenolic compounds, may reduce risks of many civilization diseases. The use of traditional medicines, mainly derived from plant sources, has become an attractive segment in the management of many lifestyle diseases. Concerning the application of dietary supplements (based on phenolic compounds) in common practice, the ongoing debate over possible adverse effects of certain nutrients and dosage levels is of great importance. Since dietary supplements are not classified as drugs, their potential toxicities and interactions have not been thoroughly evaluated. First, this review will introduce phenolic compounds as natural substances beneficial for human health. Second, the potential dual mode of action of flavonoids will be outlined. Third, potential deleterious impacts of phenolic compounds utilization will be discussed: pro-oxidant and estrogenic activities, cancerogenic potential, cytotoxic effects, apoptosis induction and flavonoid-drug interaction. Finally, future trends within the research field will be indicated.

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Section: Possible Deleterious Impacts Of Utilizing Phenolic Compoundsmentioning

confidence: 99%

Toxicological aspects of the use of phenolic compounds in disease prevention

Kyseľová¹

2011

Interdisciplinary Toxicology

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“…The protein-associated isoflavones are the major soy phytoestrogens, and mainly consist of genistein, daidzein and glycitein (Anthony et al 1996;Miniello et al 2003). Although many studies on the potential physiological functions of soy proteins and isoflavones have been conducted, the components involved in the hypolipidemic functions of soy remain controversial.…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with soy isoflavones or replacement with soy proteins prevents hepatic lipid droplet accumulation and alters expression of genes involved in lipid metabolism in rats

et al. 2013

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Accumulation of hepatic lipid droplet (HLD) is the hallmark pathology of non-alcoholic fatty liver disease (NAFLD). This study examined the effects of soy isoflavones (ISF) and different amounts of soy proteins on the accumulation of HLD, lipid metabolism and related gene expression in rats. Weanling Sprague-Dawley rats were fed diets containing either 20 % casein protein without (D1) or with (D2) supplemental ISF (50 mg/kg diet) or substitution of casein with increasing amounts of alcoholwashed soy protein isolate (SPI, 5, 10, and 20 %; D3, D4, D5) for 90 days. Dietary casein (20 %) induced accumulation of HLD in female, but not in male rats. Both soy proteins and ISF remarkably prevented the formation of HLD. Soy proteins lowered hepatic total cholesterol and triglyceride in a dose-dependent manner. Interestingly, soy proteins but not ISF significantly increased free fatty acids in the liver of the female rats compared to D1. Proteomic analysis showed that at least 3 enzymes involved in lipogenesis were down-regulated and 7 proteins related to fatty acid b-oxidation or lipolysis were up-regulated by soy protein over D1. Additionally, 9 differentially expressed proteins identified were related to amino acid metabolism, 5 to glycolysis and 2 to cholesterol metabolism. Dietary ISF and SPI markedly reduced hepatic-peroxisome-proliferator-activated receptor c2 (PPARc2) and fat-specific protein 27 (FSP27) in female rats. Overall, this study has shown that partial or full replacement of dietary casein by soy protein or supplementation with soy ISF can effectively prevent the accumulation of HLD. The potential molecular mechanism(s) involved might be due to suppression of lipogenesis and stimulation of lipolysis and down-regulation of PPARc2 and FSP27. This suggests that consumption of soy foods or supplements might be a useful strategy for the prevention or treatment of fatty liver diseases.

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“…Male Long-Evans rats exposed (from conception to time of testing or tissue collection) to a diet rich in isoflavones showed increased total T 3 levels [108]. Studies have shown that exposure of infants to soy-based formulas complicates management of congenital hypothyroidism [109][110][111][112]. Of note, estrogen replacement therapy in postmenopausal women led to higher mean TSH levels as compared to control untreated postmenopausal women [113] while in humans, isoflavones such as genistein or daidzein, can exceed the potency of estradiol, especially in infants fed soy-based formulas as a sole source of nutrition [114].…”

Section: Tsh Stimulation and Iodination Inhibitionmentioning

confidence: 99%

The menace of endocrine disruptors on thyroid hormone physiology and their impact on intrauterine development

Mastorakos

Karoutsou

Mizamtsidi

et al. 2007

Endocr

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The delivery of the appropriate thyroid hormones quantity to target tissues in euthyroidism is the result of unopposed synthesis, transport, metabolism, and excretion of these hormones. Thyroid hormones homeostasis depends on the maintenance of the circulating 'free' thyroid hormone reserves and on the development of a dynamic balance between the 'free' hormones reserves and those of the 'bound' hormones with the transport proteins. Disturbance of this hormone system, which is in constant interaction with other hormone systems, leads to an adaptational counter-response targeting to re-establish a new homeostatic equilibrium. An excessive disturbance is likely to result, however, in hypo- or hyper- thyroid clinical states. Endocrine disruptors are chemical substances forming part of 'natural' contaminating agents found in most ecosystems. There is abundant evidence that several key components of the thyroid hormones homeostasis are susceptible to the action of endocrine disruptors. These chemicals include some chlorinated organic compounds, polycyclic aromatic hydrocarbons, herbicides, and pharmaceutical agents. Intrauterine exposure to endocrine disruptors that either mimic or antagonize thyroid hormones can produce permanent developmental disorders in the structure and functioning of the brain, leading to behavioral changes. Steroid receptors are important determinants of the consequences of endocrine disruptors. Their interaction with thyroid hormones complicates the effect of endocrine disruptors. The aim of this review is to present the effect of endocrine disruptors on thyroid hormones physiology and their potential impact on intrauterine development.

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Soy‐based formulas and phyto‐oestrogens: a safety profile

Cited by 34 publications

References 104 publications

Toxicological aspects of the use of phenolic compounds in disease prevention

Toxicological aspects of the use of phenolic compounds in disease prevention

Dietary supplementation with soy isoflavones or replacement with soy proteins prevents hepatic lipid droplet accumulation and alters expression of genes involved in lipid metabolism in rats

The menace of endocrine disruptors on thyroid hormone physiology and their impact on intrauterine development

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