“…The SoxF group of transcription factors (Sox7, Sox17 and Sox18) are expressed in endothelial cells from early in development (Francois et al, 2010). While each SoxF member displays a subtly different endothelial expression pattern, all three factors are expressed early in arterial development (Corada et al, 2013;François et al, 2008;Zhou et al, 2015) and share considerable functional redundancy, complicating interpretation of the consequences of gene disruption (Hosking et al, 2009;Zhou et al, 2015). Combined loss of sox7 and sox18 in zebrafish, both by morpholino-based knockdown and genetic mutation, resulted in serious arteriovenous malformations similar to those seen after Notch ablation, suggesting that SoxF factors might genetically interact with the Notch pathway in endothelial cells (Cermenati et al, 2008;Hermkens et al, 2015;Herpers et al, 2008;Lawson et al, 2001).…”