SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development

Cuvertino, Sara; Lacaud, Georges; Kouskoff, Valérie

doi:10.1098/rsob.160070

Cited by 6 publications

(3 citation statements)

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“…Sox-17 alpha-like ( Sox-32 ) is an SRY-box ( Sox ) transcription factor that is important during development of different tissues and organs. Sox-17 has been recently reported to also control adult hematopoiesis [ 60 , 61 ] . Considering that blood precursors differentiate into several lineages of immune-relevant cell types, it might be possible that genetic variants at Sox-17 locus have a role in response to bacteria.…”

Section: Discussionmentioning

confidence: 99%

Genetics of resistance to photobacteriosis in gilthead sea bream (Sparus aurata) using 2b-RAD sequencing

Aslam

Carraro²,

Bestin

et al. 2018

BMC Genet

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BackgroundPhotobacteriosis is an infectious disease developed by a Gram-negative bacterium Photobacterium damselae subsp. piscicida (Phdp), which may cause high mortalities (90–100%) in sea bream. Selection and breeding for resistance against infectious diseases is a highly valuable tool to help prevent or diminish disease outbreaks, and currently available advanced selection methods with the application of genomic information could improve the response to selection. An experimental group of sea bream juveniles was derived from a Ferme Marine de Douhet (FMD, Oléron Island, France) selected line using ~ 109 parents (~ 25 females and 84 males). This group of 1187 individuals represented 177 full-sib families with 1–49 sibs per family, which were challenged with virulent Phdp for a duration of 18 days, and mortalities were recorded within this duration. Tissue samples were collected from the parents and the recorded offspring for DNA extraction, library preparation using 2b-RAD and genotyping by sequencing. Genotypic data was used to develop a linkage map, genome wide association analysis and for the estimation of breeding values.ResultsThe analysis of genetic variation for resistance against Phdp revealed moderate genomic heritability with estimates of ~ 0.32. A genome-wide association analysis revealed a quantitative trait locus (QTL) including 11 SNPs at linkage group 17 presenting significant association to the trait with p-value crossing genome-wide Bonferroni corrected threshold P ≤ 2.22e-06. The proportion total genetic variance explained by the single top most significant SNP was ranging from 13.28–16.14% depending on the method used to compute the variance. The accuracies of predicting breeding values obtained using genomic vs. pedigree information displayed 19–24% increase when using genomic information.ConclusionThe current study demonstrates that SNPs-based genotyping of a sea bream population with 2b-RAD approach is effective at capturing the genetic variation for resistance against Phdp. Prediction accuracies obtained using genomic information were significantly higher than the accuracies obtained using pedigree information which highlights the importance and potential of genomic selection in commercial breeding programs.Electronic supplementary materialThe online version of this article (10.1186/s12863-018-0631-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Genetics of resistance to photobacteriosis in gilthead sea bream (Sparus aurata) using 2b-RAD sequencing

Aslam

Carraro²,

Bestin

et al. 2018

BMC Genet

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“…In addition to SOX18, two other SOX transcription family members, SOX7 and SOX17, were reported to be involved in both blood vessel development and hematopoiesis 61 . We investigated their expression in our datasets and found that all three transcription factors were highly expressed in IAHCs and ECs as previously shown 43,55,56 .…”

Section: Discussionmentioning

confidence: 99%

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

Gonzalez Galofre,

Kilpatrick,

Marques

et al. 2024

Nat Commun

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Hematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesting that some hematopoiesis-supporting cells originate from vSMC precursors. These pericyte-like precursors were recently identified in the aorta-gonad-mesonephros (AGM) region; however, their role in the hematopoietic development in vivo remains unknown. Here, we identify a subpopulation of NG2+Runx1+ perivascular cells that display a sclerotome-derived vSMC transcriptomic profile. We show that deleting Runx1 in NG2+ cells impairs the hematopoietic development in vivo and causes transcriptional changes in pericytes/vSMCs, endothelial cells and hematopoietic cells in the murine AGM. Importantly, this deletion leads also to a significant reduction of HSC reconstitution potential in the bone marrow in vivo. This defect is developmental, as NG2+Runx1+ cells were not detected in the adult bone marrow, demonstrating the existence of a specialised pericyte population in the HSC-generating niche, unique to the embryo.

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“…Out of them, SOX17 is directly involved in the process of expansion of foetal HSCs [94]. A very recent study has shown that SOX7 promotes formation and proliferation of early blood progenitors; and blocks lineage commitment and formation of B lymphocytes [95].…”

Section: Regulation Of B Lymphocyte Developmental Pathway: Role Of Trmentioning

confidence: 99%

Understanding B Lymphocyte Development: A Long Way to Go

Bhattacharya¹

2019

Lymphocytes

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B lymphocytes play a significant role in both antigen-dependent and antigen-independent pathways. Although significant progress has been made in context of delineating the pathways that lead to their development, maturity and differentiation, their detailed mechanisms are yet to be dissected out completely. This chapter is aimed towards summarising the knowledge that has been gained till date and identifying the areas that need to be addressed in future research work. Overall, the chapter is planned in a sequential way to guide the reader through the processes of B cell development and the various latest findings that have improved our understanding of this vital physiological system.

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SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development

Cited by 6 publications

References 37 publications

Genetics of resistance to photobacteriosis in gilthead sea bream (Sparus aurata) using 2b-RAD sequencing

Genetics of resistance to photobacteriosis in gilthead sea bream (Sparus aurata) using 2b-RAD sequencing

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

Understanding B Lymphocyte Development: A Long Way to Go

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