2009
DOI: 10.1016/j.canlet.2008.11.014
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SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells

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Cited by 65 publications
(71 citation statements)
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“…In addition, the observed high levels of Sox7 expression in early secretory stage were also surprising, allowing us to speculate that the gene may be important for changes in cell kinetics from proliferative to secretory stages in normal endometrium, as ectopic expression of Sox7 in Sox-null cells has been demonstrated to inhibit cell proliferation. 30 Together, our observations suggest a model for functional roles of Sox4 in b-catenin/TCF4 signaling in Em Ca cells (Figure 9), dependent on upregulation of the TCF4 gene. Newly synthesized TCF4 binds to excess b-catenin, probably present due to gene mutations, 17,19 and this in turn leads to transactivation of target genes, such as TCF4 and p14 ARF , (ref.…”
Section: Hypermethylation Of Sox7 Promoter In Em Cassupporting
confidence: 56%
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“…In addition, the observed high levels of Sox7 expression in early secretory stage were also surprising, allowing us to speculate that the gene may be important for changes in cell kinetics from proliferative to secretory stages in normal endometrium, as ectopic expression of Sox7 in Sox-null cells has been demonstrated to inhibit cell proliferation. 30 Together, our observations suggest a model for functional roles of Sox4 in b-catenin/TCF4 signaling in Em Ca cells (Figure 9), dependent on upregulation of the TCF4 gene. Newly synthesized TCF4 binds to excess b-catenin, probably present due to gene mutations, 17,19 and this in turn leads to transactivation of target genes, such as TCF4 and p14 ARF , (ref.…”
Section: Hypermethylation Of Sox7 Promoter In Em Cassupporting
confidence: 56%
“…As hypermethylation of the Sox7 promoter has been reported to frequently occur in tumors, 29,30 we also examined the methylation status in Em Cas for comparison with expression levels. Methylation-specific PCR assays revealed specific signals in seven of eight Em Ca cell lines, with apparent decreases in the mRNA expression levels (Figure 8a).…”
Section: Hypermethylation Of Sox7 Promoter In Em Casmentioning
confidence: 99%
“…Many genes playing important roles in apoptosis were down-regulated during tumor progress (11)(12)(13). In this study, we show for the first time that NAIF1 is down-regulated or the expression was lost in gastric cancer tissue.…”
Section: Discussionmentioning
confidence: 63%
“…It encodes a transcription factor that can both enhance and inhibit transcription. SOX7 is mainly implicated in parietal endoderm differentiation [19]. According to the previous studies, SOX7 mRNA is undetected in some human cancer cell lines including HeLa S3 (cervical cancer), K562 (chronic myelogenous leukemia), SW480 (colorectal cancer), etc., suggesting that SOX7 might be a tumor suppressor gene in these cancers [20].…”
Section: Discussionmentioning
confidence: 99%