SOX4 exerts contrasting regulatory effects on labor-associated gene promoters in myometrial cells
Nawrah Khader,
Virlana M. Shchuka,
Anna Dorogin
et al.
Abstract:The uterine muscular layer, or myometrium, undergoes profound changes in global gene expression during its progression from a quiescent state during pregnancy to a contractile state at the onset of labor. In this study, we investigate the role of SOX family transcription factors in myometrial cells and provide evidence for the role of SOX4 in regulating labor-associated genes. We show that Sox4 has elevated expression in the murine myometrium during a term laboring process and in two mouse models of preterm la… Show more
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