SOX4: Epigenetic regulation and role in tumorigenesis

Hanieh, Hamza; Ahmed, Emad A.; Vishnubalaji, Radhakrishnan; Alajez, Nehad M.

doi:10.1016/j.semcancer.2019.06.022

Cited by 81 publications

(64 citation statements)

References 125 publications

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“…In the context of tumorigenesis, miRNAs can act as tumor suppressors, through modulation of oncogenic cellular processes, or as oncogenes, through suppression of anti-tumor cellular pathways (15,16). Altered miRNA expressions has been correlated with the pathogenesis of several human malignancies (17,18), including breast carcinomas (19), making miRNAs as valuable diagnostic and prognostic molecular biomarkers (20)(21)(22). In the past decades, miRNAs have been intensively studied in primary breast tumor tissue leading to the identification of a number of diagnostic and prognostic miRNA signatures (23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM

et al. 2020

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Section: Introductionmentioning

confidence: 99%

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM

et al. 2020

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“…Meanwhile, our study found that SP1 could inhibit the mRNA and protein expression of proliferation, apoptosis, migration, and invasion-related genes SOX4, ZEB2, MMP9, Snail, and Slug, which are all downstream molecules of TGF-β/SMAD signaling pathway [17,18]. SOX4, a member of the C-subfamily of SOX transcription factors, promotes tumorigenesis by enabling cancer cells to survive, migrate, and invade [19]; MMP9, a member of the matrix metalloproteinase (MMP) family, plays an important role in tumor migration and invasion, angiogenesis, and apoptosis [20]; the transcription factors Snail and Slug are important molecules in the EMT process, which can promote tumor invasion and metastasis, and facilitate cell survival by regulating the cell cycle and apoptosis [21,22]. erefore, we suggest that SP1 regulates the proliferation, apoptosis, migration, and invasion of gastric cancer cells by inhibiting the TGF-β/SMAD signaling pathway and the expression of downstream molecules Sox4, Zeb2, Mmp9, Snail, and Slug (Figure 8).…”

Section: Discussionmentioning

confidence: 81%

Effects of Huaier Polysaccharide SP1 on Gastric Cancer Cell Proliferation, Apoptosis, Migration, and Invasion by Regulating TGF-β/SMAD Signaling Pathway

Chen

Zhang

et al. 2020

Advances in Polymer Technology

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Objective. To study the effects of Huaier polysaccharide SP1 on the proliferation, apoptosis, migration, and invasion of gastric cancer cell line MGC-803 and the underlying mechanism. Methods. MGC-803 cells were cultured in vitro and treated with SP1. The effects of SP1 on the proliferation, apoptosis, migration, and invasion of MGC-803 cells were detected by CCK-8 assay, flow cytometry analysis, and Transwell assay, respectively. Western blot and qRT-PCR were used to detect the expression of related genes. Results. Our study showed that Huaier polysaccharide SP1 could inhibit proliferation, migration, invasion, and promote the apoptosis of MGC-803 cells in vitro in a dose-dependent manner. Huaier polysaccharide SP1 could inhibit the activation of TGF-β/SMAD signal pathway by upregulating SMAD7 expression, thereby downregulating the expression of SOX4, ZEB2, MMP9, Snail, and Slug. Conclusion. Huaier polysaccharide SP1 can regulate the proliferation, apoptosis, migration, and invasion of gastric cancer cells by promoting the expression of SMAD7 and inhibiting the activation of TGF-β/SMAD signal pathway as well as the expression of the downstream oncogenes.

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Section: Introductionmentioning

confidence: 99%

“…SOX4, one of the sox transcription factors, has been proven as an oncogene and correlated with tumor progression and development [19,20]. It has been reported that lots of miRNAs could modulate SOX4 in human cancers [19]. Kooi et al demonstrated SOX4 as novel RB driver candidates by somatic copy number alteration profiling [21].…”

Section: Introductionmentioning

confidence: 99%

XIST promotes cell proliferation and invasion by regulating miR-140-5p and SOX4 in retinoblastoma

et al. 2020

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Background: Retinoblastoma (RB) is the most common intraocular malignancy in children. Long non-coding RNA X-inactive specific transcript (lncRNA XIST) has been reported to be associated with RB, but research on the mechanism of XIST is not well studied. Methods: Expressions of XIST, microRNA-140-5p (miR-140-5p), and sex-determining region Y-related high-mobility group box 4 (SOX4) were analyzed by qRT-PCR or Western blot. Relationships of XIST, SOX4, and miR-140-5p were evaluated by dual-luciferase reporter assay and Spearman's analysis. Cell Counting Kit-8 (CCK-8) and Transwell assay were performed to assess the function of XIST on RB cell proliferation and invasion. Results: In RB tissues, XIST and SOX4 expressions were obviously increased, but the miR-140-5p expression was markedly reduced. XIST expression was positively related to SOX4 expression while negatively correlated with miR-140-5p expression, and negative correlation was exhibited between miR-140-5p and SOX4 expression in RB tissues. XIST was confirmed to directly bind to miR-140-5p, and SOX4 was one target of miR-140-5p. XIST knockdown could impede RB cell proliferation and invasion, while miR-140-5p inhibition reversed the effects. In addition, XIST overexpression or miR-140-5p inhibition could abrogate the inhibition of SOX4 silencing on cell proliferation and invasion of RB cells. Conclusions: XIST was obviously increased in RB tissues and cells, and XIST inhibition repressed the proliferation and invasion of RB cells by miR-140-5p/SOX4 axis, which may provide new understandings of the XIST molecular mechanism in RB.

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SOX4: Epigenetic regulation and role in tumorigenesis

Cited by 81 publications

References 125 publications

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM

Effects of Huaier Polysaccharide SP1 on Gastric Cancer Cell Proliferation, Apoptosis, Migration, and Invasion by Regulating TGF-β/SMAD Signaling Pathway

XIST promotes cell proliferation and invasion by regulating miR-140-5p and SOX4 in retinoblastoma

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