SOX2 maintains the stemness of retinoblastoma stem-like cells through Hippo/YAP signaling pathway

Zhao, Na; Zhou, Lei; Lü, Qianqian; Wang, Shengzhan; Sun, Ying; Ding, Yi; Liu, MengYun; He, Hengqian; Lang, Tingyuan

doi:10.1016/j.exer.2021.108887

Cited by 11 publications

(7 citation statements)

References 29 publications

(14 reference statements)

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“…SOX2 is known as a stem cell transcription factor. 29 - 31 It has been reported that SOX2 can bind to the promoter of CD133-encoding PROM1 gene, driving its transcription. 32 Zhu et al 31 reported that the SOX2-β-catenin/Beclin1 signaling pathway promotes stemness of colorectal cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling

Peng

Deng

et al. 2023

Gut and Liver

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Background/Aims: Cancer stem cells (CSCs) are believed to drive tumor development and metastasis. Activin and hepatocyte growth factor (HGF) are important cytokines with the ability to induce cancer stemness. However, the effect of activin and HGF combination treatment on CSCs is still unclear. Methods:In this study, we sequentially treated colorectal cancer cells with activin and HGF and examined CSC marker expression, self-renewal, tumorigenesis, and metastasis. The roles of forkhead box M1 (FOXM1) and sex-determining region Y-box 2 (SOX2), two stemness-related transcription factors, in activin/HGF-induced aggressive phenotype were explored.Results: Activin and HGF treatment increased the expression of CSC markers and enhanced sphere formation in colorectal cancer cells. The tumorigenic and metastatic capacities of colorectal cancer cells were enhanced upon activin and HGF treatment. Activin and HGF treatment preferentially promoted stemness and metastasis of CD133 + subpopulations sorted from colorectal cancer cells. FOXM1 was upregulated by activin and HGF treatment, and the knockdown of FOXM1 blocked activin/HGF-induced stemness, tumorigenesis, and metastasis of colorectal cancer cells. Similarly, SOX2 was silencing impaired sphere formation of activin/HGF-treated colorectal cancers. Overexpression of SOX2 rescued the stem cell-like phenotype in FOXM1-depleted colorectal cancer cells with activin and HGF treatment. Additionally, the inhibition of FOXM1 via thiostrepton suppressed activin/HGF-induced stemness, tumorigenesis and metastasis.Conclusions: Sequential treatment with activin and HGF promotes colorectal cancer stemness and metastasis through activation of the FOXM1/SOX2 signaling. FOXM1 could be a potential target for the treatment of colorectal cancer metastasis.

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Section: Discussionmentioning

confidence: 99%

Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling

Peng

Deng

et al. 2023

Gut and Liver

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“…119 Recent findings indicate that YAP/TAZ is essential for RSLC stemness, and the knockdown of YAP/TAZ drastically reduces the expression levels of RSLC markers. 120 Therefore, YAP/TAZ inhibition may be an effective therapeutic strategy for treating RB in humans.…”

Section: Rbmentioning

confidence: 99%

“…As cancer stem cells have been recognized as a source of cancer, RB stem‐like cells (RSLCs) have also been considered for RB therapy 119 . Recent findings indicate that YAP/TAZ is essential for RSLC stemness, and the knockdown of YAP/TAZ drastically reduces the expression levels of RSLC markers 120 . Therefore, YAP/TAZ inhibition may be an effective therapeutic strategy for treating RB in humans.…”

Section: Hippo Signalling Pathway In Eye Diseasesmentioning

confidence: 99%

The Hippo signalling pathway and its impact on eye diseases

2024

J Cellular Molecular Medi

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The Hippo signalling pathway, an evolutionarily conserved kinase cascade, has been shown to be crucial for cell fate determination, homeostasis and tissue regeneration. Recent experimental and clinical studies have demonstrated that the Hippo signalling pathway is involved in the pathophysiology of ocular diseases. This article provides the first systematic review of studies on the regulatory and functional roles of mammalian Hippo signalling systems in eye diseases. More comprehensive studies on this pathway are required for a better understanding of the pathophysiology of eye diseases and the development of effective therapies.

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“… 210 Moreover, knockdown YAP partially abolished the stemness of CD44 + retinoblastoma stem‐like cells. 211 …”

Section: Cancer‐associated Pathways Regulated By Cd44mentioning

confidence: 99%

CD44 and its implication in neoplastic diseases

Xu,

Bai,

Lan

et al. 2024

MedComm

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CD44, a nonkinase single span transmembrane glycoprotein, is a major cell surface receptor for many other extracellular matrix components as well as classic markers of cancer stem cells and immune cells. Through alternative splicing of CD44 gene, CD44 is divided into two isoforms, the standard isoform of CD44 (CD44s) and the variant isoform of CD44 (CD44v). Different isoforms of CD44 participate in regulating various signaling pathways, modulating cancer proliferation, invasion, metastasis, and drug resistance, with its aberrant expression and dysregulation contributing to tumor initiation and progression. However, CD44s and CD44v play overlapping or contradictory roles in tumor initiation and progression, which is not fully understood. Herein, we discuss the present understanding of the functional and structural roles of CD44 in the pathogenic mechanism of multiple cancers. The regulation functions of CD44 in cancers‐associated signaling pathways is summarized. Moreover, we provide an overview of the anticancer therapeutic strategies that targeting CD44 and preclinical and clinical trials evaluating the pharmacokinetics, efficacy, and drug‐related toxicity about CD44‐targeted therapies. This review provides up‐to‐date information about the roles of CD44 in neoplastic diseases, which may open new perspectives in the field of cancer treatment through targeting CD44.

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SOX2 maintains the stemness of retinoblastoma stem-like cells through Hippo/YAP signaling pathway

Cited by 11 publications

References 29 publications

Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling

Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling

The Hippo signalling pathway and its impact on eye diseases

CD44 and its implication in neoplastic diseases

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