“…SRY-box transcription factor 2 (SOX2) is not only a pluripotent stem cell-related factor but also a key transcription factor and serves a role in maintaining stem cell properties and determining the fate of cells (23). Researchers have revealed that SOX2 is aberrantly expressed in different types of cancer and that SOX2 expression is positively associated with cancer cell stemness and multi-drug resistance (24)(25)(26). Therefore, SOX2 may be an attractive therapeutic target for overcoming chemotherapy resistance.…”