Sox2 in the dermal papilla regulates hair follicle pigmentation

Ng, Krystle Joy; Lim, Jamien; Tan, Yolanda Nwayhtetmaw; Quek, Delia; Lim, Zoe Zon Be; Pantelireis, Nikolaos; Clavel, Carlos

doi:10.1016/j.celrep.2022.111100

Cited by 11 publications

(6 citation statements)

References 55 publications

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“…Versican, β-catenin, and ALP are considered molecular markers of DPCs. Sox2 is known to be expressed in DPCs and regulates the hair pigment [34].…”

Section: Resultsmentioning

confidence: 99%

Dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by activating Wnt/β‐catenin signaling pathway

Shang,

Li,

Zhang

et al. 2024

Preprint

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Hair follicle (HF) regeneration after skin injury remains a major clinical challenge. Dermal papilla cell-derived exosomes (DPC-Exos) have great potential to induce HF neogenesis. However, the role and mechanism of DPC-Exos in HF regeneration during wound healing are still unclear. In this study, the effect of DPC-Exos on fibroblasts in wound healing was explored for the first time. We found that DPC-Exos could promote the proliferation and migration of fibroblasts, and more importantly, enhance the hair-inducing capacity of fibroblasts. The fibroblasts treated with DPC-Exos could induce HF neogenesis in nude mice when combined with neonatal mice epidermal cells. In addition, the results of in vivo experiments showed that DPC-Exos could accelerate wound re-epithelialization, and promote HF regeneration. The expression levels of Wnt pathway transcription factor β-catenin and Lef1 were elevated in fibroblasts and the dermis of skin wounds after DPC-Exos treatment. Taken together, this study proved that DPC-Exos could promote HF regeneration during wound healing by activating fibroblasts and the Wnt/β-catenin signaling pathway, suggesting that DPC-Exos might be a promising therapeutic strategy for skin wound regenerative healing.

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“…Versican, β-catenin, and ALP are considered molecular markers of DPCs. Sox2 is known to be expressed in DPCs and regulates the hair pigment [34].…”

Section: Resultsmentioning

confidence: 99%

Dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by activating Wnt/β‐catenin signaling pathway

Shang,

Li,

Zhang

et al. 2024

Preprint

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“…LEP and its receptor (LEPR) were observed expressed in hair follicles of bovine skin [59]. It has been revealed that Lepr expressed in dermal condensates during HFs morphogenesis, and Lepr could as a marker for dermal papilla cell isolation [60]. HEPHL1 is a member of the multicopper oxidase family, it has been reported that two mutations in HEPHL1 caused abnormal hair phenotype, and the Hephl1 knockout mice appeared with curly whiskers [61].…”

Section: Discussionmentioning

confidence: 99%

Genome-wide detection of RNA editing events during the hair follicles cycle of Tianzhu white yak

et al. 2022

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Background The hair coat is available for the yak to live in the harsh environment of the plateau. Besides, improving the hair production of yak is necessary for its textile industry development. Hair grows from hair follicles (HFs). The HFs undergo periodic growth after birth and are regulated by the complex gene regulatory network. However, the molecular mechanism of HFs regeneration in the Tianzhu white yak remains unclear. RNA editing is a post-transcriptional mechanism that regulates gene expression and produces new transcripts. Hence, we investigated the influence of the A-to-I RNA editing events on the HFs cycle of the Tianzhu white yak. Results We finally identified 54,707 adenosine-to-inosine (A-to-I) RNA editing sites (RESs) from RNA sequencing data of the HFs cycle in the Tianzhu white yak. Annotation results showed RESs caused missense amino acid changes in 7 known genes. And 202 A-to-I editing sites altered 23 target genes of 140 microRNAs. A total of 1,722 differential RESs were identified during the HFs cycle of Tianzhu white yak. GO and KEGG enrichment analysis revealed several signaling pathways and GO terms involved skin development, hair growth, and HFs cycle. Such as genes with differential RNA editing levels were significantly enriched in the peroxisome, metabolic pathways, Notch signaling pathway, and PPAR signaling pathway. Besides, the editing sites in HFs development-related genes FAS, APCDD1, WWOX, MPZL3, RUNX1, KANK2, DCN, DSC2, LEPR, HEPHL1, and PTK2B were suggested as the potential RESs involving HFs development. Conclusion This study investigated the global A-to-I RNA editing events during the HFs cycle of yak skin tissue and expanded the knowledge of A-to-I RNA editing on the HFs cycle. Furthermore, this study revealed that RNA editing-influenced genes may regulate the HFs cycle by participating in the HFs development-related pathways. The findings might provide new insight into the regulation of RNA editing in hair growth.

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“…Methods to increase blood flow on the scalp include scalp massage and Minoxidil, and methods to stimulate hair follicles include prostaglandins and lasers. For an animal model of hair loss, DHT can induce regression and morphological change of DPCs in male C57BL/6 mice in a dose-dependent manner [ 105 ]; the skin remained gray after 7 days of anagen, and then turned white again with the apoptosis of melanocytes [ 106 ].…”

Section: Skin Diseasesmentioning

confidence: 99%

Exosomal microRNA-Based therapies for skin diseases

Jibing,

Weiping,

Yuwei

et al. 2024

Regenerative Therapy

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Sox2 in the dermal papilla regulates hair follicle pigmentation

Cited by 11 publications

References 55 publications

Dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by activating Wnt/β‐catenin signaling pathway

Dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by activating Wnt/β‐catenin signaling pathway

Genome-wide detection of RNA editing events during the hair follicles cycle of Tianzhu white yak

Exosomal microRNA-Based therapies for skin diseases

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