Sox10‐positive sustentacular cells in neuroendocrine carcinoma of the lung

Tsuta, Koji; Raso, Maria Gabriela; Kalhor, Neda; Liu, Diane C; Wistuba, Ignacio I.; Moran, César A.

doi:10.1111/j.1365-2559.2011.03747.x

Cited by 18 publications

(13 citation statements)

References 18 publications

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“…Most of the vimentin‐positive cells in our study were considered to be sustentacular cells, because the positive cells had a stellate shape and several authors have reported that 18–82% of pulmonary carcinoid tumours contain sustentacular cells 35,36 . We have found recently that the presence of sustentacular cells differs in the morphological subtypes of carcinoid tumour, with spindle‐cell types being the most prevalent subtype 37 . This immunostaining pattern of SCCTs with regard to intratumoural sustentacular cells might result in a misdiagnosis of mesenchymal tumour.…”

Section: Discussionmentioning

confidence: 58%

Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung

et al. 2011

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Section: Discussionmentioning

confidence: 58%

Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung

et al. 2011

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“…This scenario is particularly well illustrated in paragangliomas arising in unusual organs such as thyroid, lung, and pancreas where the diagnosis of medullary carcinoma, carcinoid tumor, or islet cell tumor might be considered. Sustentacular cells characteristic of paraganglioma can be seen in carcinoid tumors and neuroendocrine carcinomas of a variety of organs, [22][23][24] and the Zellballen pattern can be seen as well. 25 In addition, a subset of paragangliomas show cytokeratin expression, which might further support the diagnosis of carcinoid tumors, 26 or, alternatively, the possibility of carcinoma might be raised.…”

Section: Discussionmentioning

confidence: 99%

A Study of Gata3 and Phox2b Expression in Tumors of the Autonomic Nervous System

Nonaka

Wang

Edmondson

et al. 2013

American Journal of Surgical Pathology

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Autonomic neurons and chromaffin cells, which constitute the autonomic nervous system, are derived from a common progenitor from the neural crest, and its development is controlled by a network of transcription factors, including the master regulator, Phox2b, and its downstream, Gata3. Anti-Phox2b and anti-Gata3 antibodies were applied to a total of 77 autonomic nervous system tumors, including 35 paragangliomas, 21 pheochromocytomas, 9 neuroblastomas, 4 ganglioneuroblastomas, and 8 ganglioneuromas, as well as their potential morphologic mimics, including tumors of the small round cell tumor group, neuroendocrine carcinomas of lung and gastrointestinal tract (carcinoid tumors/neuroendocrine tumors, large cell neuroendocrine carcinomas, and small cell carcinomas), Merkel cell carcinomas, benign and malignant tumors of thyroid, parathyroid, and adrenal cortex, and malignant melanomas. A variety of nonendocrine/neuroendocrine carcinomas were also studied. Gata3 expression was seen in 89% of paragangliomas, 95% of pheochromocytomas, and all neuroblastomas, ganglioneuroblastomas, and ganglioneuromas, as well as in all parathyroid tumors, a majority of urothelial and mammary carcinomas, and a subset of squamous cell carcinomas, but all other tumors were negative. Phox2b expression was seen in all neuroblastomas, ganglioneuroblastomas, and ganglioneuromas and in 40% of paragangliomas, but pheochromocytomas and all other tumors were negative. Gata3 is a highly reliable marker for paragangliomas, pheochromocytomas, and neuroblastic tumors to distinguish from their simulators. This is an additional utility for this marker, which is used for the diagnosis of urothelial and mammary carcinomas. Phox2b is also highly specific, but its low sensitivity to paragangliomas and pheochromocytomas would limit the utility only to neuroblastic tumors.

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“…They regulate various developmental processes, and their encoded proteins are involved in different tumors as tumor promoter or suppressor. Sox10 is overexpressed in peripheral neural and melanocytic tumors [11] and in solid tumors such as neuroendocrine tumor of the lung [13], basal-like, triple-negative and metaplastic carcinoma of breast [14], and hepatocellular carcinoma [17]. Sox10 knockdown in human melanoma cells induces senescence and suppresses melanomagenesis [18].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Sox10 has also been found in some human solid tumors. For example, in neuroendocrine tumors of the lung, it is expressed by sustentacular cells, the presence of which is inversely correlated with neuroendocrine tumor grade [13]. Sox10 expression has been reported in basal-like, triple-negative and metaplastic carcinoma of breast [14], acinic cell carcinoma, adenoid cystic carcinoma, myoepithelial carcinoma, pleomorphic adenoma of salivary gland [15,16], and hepatocellular carcinoma [17].…”

Section: Introductionmentioning

confidence: 97%

Sox10 expression in ovarian epithelial tumors is associated with poor overall survival

et al. 2016

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Sox10 is a transcription factor regulating the development of several cell lineages and is involved in tumor development. However, the clinicopathological relevance of Sox10 expression in ovarian cancer has not been examined. We assessed expression of Sox10 in ovarian epithelial tumors by immunohistochemistry and assessed its prognostic value by analyzing the correlation between its expression and clinicopathological factors. We used tissue microarrays including 244 ovarian epithelial tumors. Sox10 staining was found in the cytoplasm or nucleus of tumor cells. Malignant serous, mucinous, and endometrioid tumors were significantly more likely to express Sox10 than benign and borderline tumors. Expression patterns in adenocarcinomas were different for histologic subtypes: nuclear Sox10 staining was common in clear-cell adenocarcinomas and serous adenocarcinomas, whereas all cases of mucinous and endometrioid tumors were negative for nuclear staining. Nuclear Sox10 staining was also associated with chemoresistance and shorter overall survival in ovarian adenocarcinomas, notably in high-grade serous adenocarcinoma. Sox10 is expressed in many ovarian carcinomas, suggesting that it might be involved in oncogenesis of ovarian carcinoma. Expression pattern of Sox10 differs between histological subtypes. Nuclear Sox10 expression is an independent indicator of poor prognosis in ovarian adenocarcinomas, notably in high-grade serous adenocarcinomas.

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Sox10‐positive sustentacular cells in neuroendocrine carcinoma of the lung

Abstract: Sox10-positive sustentacular cells were observed in carcinoid tumours but not in high-grade NECs. Sustentacular-rich carcinoid tumours did not show a correlation with the occurrence of lymph node metastasis or survival. The sustentacular cells found differed in morphological subtypes.

Cited by 18 publications

References 18 publications

Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung

Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung

A Study of Gata3 and Phox2b Expression in Tumors of the Autonomic Nervous System

Sox10 expression in ovarian epithelial tumors is associated with poor overall survival

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