Sovremennye aspekty mestnogo lecheniya khronicheskikh ran nizhnikh konechnostey u bol'nykh sakharnym diabetom

New synthesis of 2,3-dihydro-thiazolo[3,2-a]benzimidazoles

“…The use of asymmetric thiiranes 2b and 2c leads to 2-substituted dihydrothiazolobenzimidazoles 3b and 3c. The structure of these compounds was confirmed by the convergent synthesis of 2-(1-piperidinylmethyl)-2,3-dihydrothiazolo[3,2-a]benzimidazole (3c) by the reaction of 2-methylsulfonyl-1-(thiiranyl-2-methyl)benzimidazole with piperidine [3]. The characteristics of samples of benzimidazole 3c prepared by different methods were identical, which confirms opening of the thiirane ring according to the Krasusskii rule [4].…”

“…The precipitate was filtered off, washed with water, and dried to give 1.34 g (49%) compound 3c, mp 138-139°C (hexane). 1 H NMR spectrum, δ, ppm (J, Hz): 1.38-1.50 (2H, m, CCH 2 ); 1.52-1.62 (4H, m, 2CCH 2 ); 2.35-2.50 (4H, m, N(CH 2 ) 2 ); 2.65 (1H, dd, 3 J = 7.7, 2 J = 12.7, 2-CH 2 ); 2.70 (1H, dd, 3 J = 7.9, 2 J = 12.7, 2-CH 2 ); 4.08 (1H, dd, 3 …”

“…Several methods have been developed for synthesis of the 2,3-dihyhdrothiazolo[3,2-a]benzimidazole system: 1) Alkylation of 2-mercaptobenzimidazoles by 1,2-dihaloethanes [1]; 2) cyclization of 1-(2-hydroxyalkyl)-2-mercaptobenzimidazoles by dehydrating reagents [2], and 3) reaction of 2-methylsulfonyl-1-(thiiranyl-2-methyl)benzimidazoles with nucleophilic reagents [3].…”

Ultrastructural characteristics of chemodectomas

“…Radioautographs were prepared as described elsewhere [5]. The preparations were examined under light (Leitz) and electron (Phillips CM-10) microscopes.…”

“…Study of morphofunctional peculiarities of tumors is an important component in evaluation of their biological behavior and prognosis. This is particularly important for neuroendocrine tumors, especially for neck chemodectomas, which have no clear-cut microscopic signs of malignancy [5,9].…”