South Asian women with polycystic ovary syndrome exhibit greater sensitivity to gonadotropin stimulation with reduced fertilization and ongoing pregnancy rates than their Caucasian counterparts

Palep-Singh, Manisha; Picton, HM; Vrotsou, Kalliopi; Maruthini, Deivanayagam; Balen, Adam

doi:10.1016/j.ejogrb.2007.02.005

Cited by 64 publications

(46 citation statements)

References 31 publications

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“…PCOS is a heterogeneous disease, but we did not classify our patients due to the clinical phenotypes. Secondly, since most of the original studies derived from European population and the metabolic parameters seemed to be different in PCOS patients with different ethnic descents [44][45][46][47], our findings may not be extended to other descent. Thirdly, due to the limited numbers of original researches enrolled, our results are not conclusive.…”

Section: Discussionmentioning

confidence: 79%

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

Wang

Liu

et al. 2012

J Assist Reprod Genet

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Purpose To investigate the influence of the peroxisome proliferator activated receptor gamma (PPAR-γ) Pro12Ala polymorphism on the susceptibility of polycystic ovary syndrome (PCOS) and body mass index (BMI), fast insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR) in PCOS patients. Methods PubMed, EMBASE, MEDLINE and CENTRAL databases were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between Pro12Ala polymorphism and PCOS. Results Seventeen eligible studies, including 2,149 patients and 2,124 controls were enrolled in this meta-analysis. Conclusions Ala variant would decrease the risk of PCOS and result in lower BMI and fast insulin levels in a European population, but had no impact on HOMA-IR in PCOS patients. Further studies are required to elucidate these associations more clear.

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Section: Discussionmentioning

confidence: 79%

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

Wang

Liu

et al. 2012

J Assist Reprod Genet

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“…Prior studies examining ART outcomes among women with PCOS have reported higher oocyte yield per cycle, but lower fertilization rates, suggesting a compromise in the oocyte quality [ 22 ]. A study comparing ART outcomes between South Asian and Caucasian women with PCOS found that South Asian women exhibited a higher sensitivity to gonadotropins [ 19 ]. Compared to their Caucasian counterparts, the South Asian patients required signifi cantly less gonadotropin stimulation with a resultant higher oocyte yield, although a lower fertilization and implantation potential, suggesting an ethnic-mediated discrepancy in hormonal receptivity or metabolism [ 19 ].…”

Section: Understanding Disparity In Treatment Outcomesmentioning

confidence: 95%

“…For those who are not able to conceive with ovulation induction alone, most often in women with multiple factors contributing to their infertility, ART is a viable option. One study from the United Kingdom compared ethnic variations in response to IVF/ICSI treatment in women with PCOS refractory to standard ovulation induction [ 19 ]. Using women with tubal disease for comparison, the two ethnic groups compared were South Asian immigrants from the Indian subcontinent and British Caucasians.…”

Section: Art Outcomes Among Women Of South Asian Ethnicitymentioning

confidence: 98%

“…However, even with this increase in oocyte production, the four groups had similar number of mature oocytes, with a reduction in fertilization rates in the South Asian women with PCOS; the fertilization rates among the other groups were similar. Furthermore, South Asian women with PCOS were 3.53 times more likely to experience miscarriage than their Caucasian PCOS counterparts [ 19 ]. In another study of IVF outcomes of Indian women in Britain, Mahmud et al found evidence of poorer IVF performance compared to Caucasian women [ 20 ].…”

Section: Art Outcomes Among Women Of South Asian Ethnicitymentioning

confidence: 99%

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Differences in Fertility and Assisted Reproduction in South Asian Women

Gustin

Lee

Westphal

2013

Ethnic Differences in Fertility and Assisted Reproduction

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IntroductionAs racial and ethnic disparities are being recognized in all areas of medicine, interest in outcomes of assisted reproductive technology (ART) in different groups, such as South Asian women, has increased signifi cantly. Unfortunately, the true incidence of infertility in these women at a national level within the United States is unknown, as there is a lack of literature examining fertility across multiple ethnic groups living in the same geographic region. One reason for this limited information is lack of reporting. One study that systematically reviewed SART data from 1999 to 2007 found it diffi cult to draw conclusions on disparity outcomes due to the lack of universal reporting of race and ethnicity by practices. The study concluded that 35 % of cycles could not be used in their analysis because the data on race/ethnicity were indeterminate [ 1 ]. A recent study has shown an increased reporting in race, suggestive of a trend in the right direction [ 2 ]. However, many studies group all Asian women together (Chinese, Japanese, Indian, etc.), which makes analysis of data more diffi cult.Despite the lack of information, we can use other data to extrapolate the prevalence of infertility in South Asian women. Overall, infertility in the United States

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“…Many factors could have been responsible on this contradiction such as ovulation induction program, patient age and ethnicity [34], and BMI. The present study shows high pregnancy rates in patients with PCOS or PCOM.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes in Infertile Women with Polycystic Ovaries following Intracellular Sperm Injection

2017

IJSR

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Polycystic ovary syndrome (PCOS) is a complex endocrine condition characterized by polycystic ovarian morphology (PCOM), oligo-or anovulation, and clinical or biochemical hyperandrogenism. Intracytoplamic sperm injection (ICSI) has been used extensively in treatment of infertile women with PCOS. In Iraq, pregnancy outcomes in PCOS patients following ICSI have yet to be evaluated. This study has therefore been conducted to define pregnancy outcomes in Iraqi PCOS patients as well as to define oocyte meiotic competence and normality following ovarian hyperstimulation. Although high doses of gonadotropin were used in infertile women with normal ovaries, the numbers of retrieved oocytes and estradiol peak levels were higher in patients with PCOM and PCOS than in patients with normal ovaries(P≤0.01). Wealso found that PCOM women have higher antral follicle count (AFC) than did PCOS women(P=0.0001). Moreover, significant high mean numbers of immature, mature, and degenerated oocytes were observed in PCOS and PCOM patients in comparison to those in control patient, which might be due to the high bulk of AFC and consequently higher numbers of oocyte recovered in PCOS or PCOM. As for ICSI outcomes, PCOS or PCOM patients had significantly higher fertilization, grade one embryo, embryo transfer and implantation, pregnancy, and live birth rates than did control patients. It is concluded that infertile women with PCOS or PCOM have higher pregnancy rates than do infertile women with unexplained or tubal-type infertility following ICSI.

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South Asian women with polycystic ovary syndrome exhibit greater sensitivity to gonadotropin stimulation with reduced fertilization and ongoing pregnancy rates than their Caucasian counterparts

Cited by 64 publications

References 31 publications

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

Differences in Fertility and Assisted Reproduction in South Asian Women

Pregnancy Outcomes in Infertile Women with Polycystic Ovaries following Intracellular Sperm Injection

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