South Asian and European colitics show characteristic differences in colonic mucus glycoprotein type and turnover.

Probert, Chris; Warren, Bryan F.; Perry, Tracy B.; MacKay, E H; Mayberry, J F; Corfield, Anthony P.

doi:10.1136/gut.36.5.696

Cited by 42 publications

(20 citation statements)

References 29 publications

(7 reference statements)

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“…In brief, slides were immersed in HID solution for 18-24 h (Mowry 1963;Spicer 1965;Probert et al 1995). After washing in 3% acetic acid, slides were then immersed in alcian blue (10 mg/ml) solution (pH 2.5) for 30 min.…”

Section: Histochemical Methodsmentioning

confidence: 99%

Alteration of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis

et al. 2008

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Acidic mucins such as sialomucin and sulfomucin produced by intestinal epithelial cells have been implicated in the protection of the mucosa from pathogens. In the present study, we analyzed the alteration of acidic mucins in the jejunum of euthymic and athymic rats infected with the nematode Nippostrongylus brasiliensis using alcian blue staining and a high iron-diamine method. The numbers of sialomucin+ goblet cells increased markedly 7 and 10 days post-infection and decreased gradually thereafter in euthymic rats, while athymic rats did not show sialomucin+ goblet cell hyperplasia at least until 28 days post-infection, suggesting that sialomucin production might be regulated by thymus-derived T cells. On the other hand, the numbers of sulfomucin+ goblet cells increased markedly 28 days post-infection in both euthymic and athymic rats despite the fact that sulfomucin+ goblet cell numbers in uninfected athymic rats were significantly smaller than in euthymic rats. Real-time polymerase chain reaction studies on the gene transcription levels of O-glycan sulfotransferases Gal3ST1, Gal3ST2, Gal3ST3, and Gal3ST4 in the jejunal epithelium increased gradually toward day 28 post-infection in euthymic and athymic rats. These results suggest that the production of sulfomucin and expression of Gal3STs are inducible by nematode infection without the activation of thymus-derived T cells.

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Section: Histochemical Methodsmentioning

confidence: 99%

Alteration of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis

et al. 2008

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“…8 -10 In addition, a study from Leicestershire, United Kingdom, showed that the pattern of colonic mucin synthesized in migrant South Asian patients with UC differs with that in European patients with UC. 11 Another study from Leicestershire also suggested that migrant South Asian patients with UC have a lower risk of colectomy than do European patients. 12 These results suggest that there could be some differences between Asian and Western populations in the development and clinical course of UC.…”

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confidence: 97%

Clinical features and natural history of ulcerative colitis in Korea

Park

Kim

Yang

et al. 2007

Inflammatory Bowel Diseases

112

104

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“…IBD is most common in highly industrialized temperate regions and is rare in tropical countries with poor sanitation and overcrowding (17). The rarity of IBD in tropical countries cannot be explained on the basis of genetics alone, as descendants of immigrants from such countries acquire the higher risk of IBD of the adopted developed country (32,40). These observations underscore the importance of environmental factors in the expression of IBD and have led to the development of the "hygiene hypothesis" of IBD, that is, that IBD occurs more commonly in societies where the prevalence of chronic enteric infestation is low (17).…”

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confidence: 99%

Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice

et al. 2002

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Epidemiological studies suggest that inflammatory bowel disease (IBD) is common in developed countriesIn the present study, we investigated the effect of polarizing the immune response toward the Th2 type, using intestinal nematode infection, on subsequent experimental colitis. Mice were infected with the intestinal nematode Trichinella spiralis and allowed to recover before colitis was induced with dinitrobenzene sulfonic acid. The mice were sacrificed postcolitis to assess colonic damage macroscopically, histologically, and by myeloperoxidase (MPO) activity and Th cytokines. Prior nematode infection reduced the severity of colitis both macroscopically and histologically together with a decreased mortality and was correlated with a downregulation of MPO activity, Th1-type cytokine expression in colonic tissue, and emergence of a Th2-type immune response. These results indicate a protective role of nematode infection in Th1 cell-driven inflammation and prompt consideration of a novel therapeutic strategy in IBD based on immunological distraction.

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South Asian and European colitics show characteristic differences in colonic mucus glycoprotein type and turnover.

Abstract: (Gut 1995; 36: 696-702)

Cited by 42 publications

References 29 publications

Alteration of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis

Alteration of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis

Clinical features and natural history of ulcerative colitis in Korea

Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice

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